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OSS Lab

Welcome to the OSS Lab

Headed by Orkun S. Soyer, the current focus of the OSS lab is to develop a predictive and quantitative understanding of cellular metabolism and metabolic interactions among cells.

Current key areas of research

1. Emergence and evolution of metabolic excretions and interactions in microbes (funded by NSF/BBSRC) (in collaboration with Wenying Shou).

2. Feedbacks between metabolism at cell level and spatial organisation at population level (funded by Gordon and Betty Moore Foundation).

3. Electrical control of cellular metabolism (funded by Cancer Research UK) (in collaboration with Pat Unwin).

4. Deciphering microbial interactions in microbial communities using temporal metagenomics (currently in-between funding) (in collaboration with Christopher Quince).

5. Modelling of metabolic dynamics (currently in-between funding) (in collaboration with Elisenda Feliu and Alex Fletcher).

For additional information please see our 'Research' page and affiliated project: Bio-Electrical Engineering Innovation Hub.

You can access code/software from our GitHub page and we have started to use Protocols.io to make our lab protocols easily available (more will be added over the next few months).

See also our past projects on anaerobic microbial communities: Engineering Synthetic Microbial Communities for Biomethane Production and Monitoring UK Anaerobic Digestion Microbiomes.

Our Funders

betty moore logo

BBSRC 2019 logo

CRUK logo

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News

Book Chapter (August 2021)

'An Evolutionary Systems Biology View on Metabolic System Structure and Dynamics' by Johnson C., Delattre H., Hayes C., Soyer O.S. In: Crombach A. (eds) Evolutionary Systems Biology. Link

New Publication (July 2021)

'STRONG: metagenomics strain resolution on assembly graphs'. Quince, C., Nurk, S., Raguideau, S. Soyer OS et al. Genome Biol 22, 214. Link

Pre-Print news (July 2021)

'Novel microbial syntrophies identified by longitudinal metagenomics' by Sebastien Raguideau, Anna Trego, Fred Farrell, Gavin Collins, Christopher Quince, Orkun S Soyer. bioRxiv link

OSS Lab Pre-Print (May 2021)

'Multi-site enzymes as a mechanism for bistability in reaction networks' by Clarmyra Hayes, Elisenda Feliu, Orkun S Soyer. bioRxiv link

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