Second year PhD student in the Gibson group based within the Department of Chemistry and Warwick Medical School, under the supervision of Prof. Matthew Gibson (supervisor) and Dr Daniel Mitchell (co-supervisor; Warwick Medical School).
My PhD project focuses on "Glycocalyx Remodelling to Enable Quality by Design Cell-Based Therapy". Glycocalyx engineering through metabolic labelling, a technique pioneered by Carolyn Bertozzi has enabled the incorportation of unnatural sugars onto cell membranes through promiscious biosynthetic pathways. Subsequent bioorthogonal reactions have been utilised to incorporate small molecule probes. My PhD focuses using unnatural sugars as anchors to remodel cell surfaces with macromolecules to enable the rational design of high-quality cell-based therapies. High-resolution analytical methods are utilised to determine the biocompatibility and efficency of such methods.
Fig. 1. Cell surface modification with azido sugars and bioorthogonal small molecule probes.
- Glycocalyx remodelling to recruit macromolecules to cell surfaces
- Utilising natural and synthetic polymers to enhance cryopreservation
- Antimicrobial polymers.
- R. M. F. Tomás, B. Martyn, T. L. Bailey and M. I. Gibson, ACS Macro Lett., 2018, 7,1289–1294. "Engineering Cell Surfaces by Covalent Grafting of Synthetic Polymers to Metabolically-Labeled Glycans"
- S. Richards, A. Jones, R. M. F. Tomás and M. I. Gibson, Chem. A Eur. J., 2018, 24, 13758–13761. "Photochemical “In‐Air” Combinatorial Discovery of Antimicrobial Co‐polymers"
MSc in Molecular Analytical Science at The University of Warwick (2016-2017)
Graduated with Pass with Distinction.
Activities and Societies: Student Staff Liason Officer for Molecular Analytical Science at The University of Warwick (2017). Outreach Officer for The University of Warwick's Chemistry Society (2017). STEM ambassador for The Royal Society of Chemistry (2017-onwards).
BSc (Hons) in Forensic Science at Nottingham Trent University (2013-2016)
Graduated with First Class Honours.
Activities and Societies: Course Representative for Forensic Science at Nottingham Trent University (2014). Student member of the Chartered Society of Forensic Sciences (2013-2016).
July 2017 - September 2017
Electrochemical sensing directly in bodily fluids – a move towards point of care and in vivo analysis
Supervised by Professor Julie Macpherson (Warwick Electrochemistry and Interfaces Group, Department of Chemistry) and Dr Tony Bristow (Astra Zeneca, Industry Supervisor).
April 2017 - July 2017
Conquering poor resolution in fast magic angle spinning solid-state NMR spectra of noncrystallisable protein assemblies.
Supervised by Dr Józef Lewandowski (The University of Warwick's Solid State NMR Group, Department of Chemistry) and Dr Peter Gierth (Bruker, Industry Supervisor).
Jan 2016 - April 2016
Dye-Doped Silica Nanoparticles and Microparticles for Fingermark Enhancement.
Supervised by Dr Muriel Funck (School of Science & Technology, Nottingham Trent University).
Nottingham Trent University, Summer Placement
July 2015 - September 2015
Synthesis of Novel Antimalarial Compounds derived from the Codinaeopsin Scaffold.
Supervised by Dr Liam Duffy (School of Science & Technology, Nottingham Trent University).
First Place Poster Prize Winner at the Molecular Analytical Science Centre for Doctoral Training Annual Conference.
Poster Prize Winner at the Molecular Analytical Science Centre for Doctoral Training Annual Conference.
Winner of the Trent Institute for Learning and Teaching Research in Undergraduate Studies Award. In recognition of having the best research project in the School of Science and Technology in 2015/2016.
Orcid ID: https://orcid.org/0000-0002-7191-2539
MOAC Department, Top floor Senate House, Universty of Warwick, Coventry, CV4 7AL.
The University of Warwick.