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Ruben Tomas

Second year PhD student in the Gibson group based within the Department of Chemistry and Warwick Medical School, under the supervision of Prof. Matthew Gibson (supervisor) and Dr Daniel Mitchell (co-supervisor; Warwick Medical School).

My PhD project focuses on "Glycocalyx Remodelling to Enable Quality by Design Cell-Based Therapy". Glycocalyx engineering through metabolic labelling, a technique pioneered by Carolyn Bertozzi has enabled the incorportation of unnatural sugars onto cell membranes through promiscious biosynthetic pathways. Subsequent bioorthogonal reactions have been utilised to incorporate small molecule probes. My PhD focuses using unnatural sugars as anchors to remodel cell surfaces with macromolecules to enable the rational design of high-quality cell-based therapies. High-resolution analytical methods are utilised to determine the biocompatibility and efficency of such methods.

Cell surface labelling with azido sugars and small molecule probes

Fig. 1. Cell surface modification with azido sugars and bioorthogonal small molecule probes.


Research Interests
  • Glycocalyx remodelling to recruit macromolecules to cell surfaces
  • Utilising natural and synthetic polymers to enhance cryopreservation
  • Antimicrobial polymers.


Publications

  1. R. M. F. Tomas, B. Martyn, T. L. Bailey and M. I. Gibson, ACS Macro Lett., 2018, 7,1289–1294. "Engineering Cell Surfaces by Covalent Grafting of Synthetic Polymers to Metabolically-Labeled Glycans"
  2. S. Richards, A. Jones, R. M. F. Tom and M. I. Gibson, Chem. A Eur. J., 2018, 24, 13758–13761. "Photochemical “In‐Air” Combinatorial Discovery of Antimicrobial Co‐polymers"


Academic Background

MSc in Molecular Analytical Science at The University of Warwick (2016-2017)

Graduated with Pass with Distinction.

Activities and Societies: Student Staff Liason Officer for Molecular Analytical Science at The University of Warwick (2017). Outreach Officer for The University of Warwick's Chemistry Society (2017). STEM ambassador for The Royal Society of Chemistry (2017-onwards).

BSc (Hons) in Forensic Science at Nottingham Trent University (2013-2016)

Graduated with First Class Honours.

Activities and Societies: Course Representative for Forensic Science at Nottingham Trent University (2014). Student member of the Chartered Society of Forensic Sciences (2013-2016).


Previous Research

University of Warwick, MSc Research Project 2

July 2017 - September 2017

Electrochemical sensing directly in bodily fluids – a move towards point of care and in vivo analysis

Supervised by Professor Julie Macpherson (Warwick Electrochemistry and Interfaces Group, Department of Chemistry) and Dr Tony Bristow (Astra Zeneca, Industry Supervisor).

University of Warwick, MSc Research Project 1

April 2017 - July 2017

Conquering poor resolution in fast magic angle spinning solid-state NMR spectra of noncrystallisable protein assemblies.

Supervised by Dr Józef Lewandowski (The University of Warwick's Solid State NMR Group, Department of Chemistry) and Dr Peter Gierth (Bruker, Industry Supervisor).

Nottingham Trent University, Final Year Project

Jan 2016 - April 2016

Dye-Doped Silica Nanoparticles and Microparticles for Fingermark Enhancement.

Supervised by Dr Muriel Funck (School of Science & Technology, Nottingham Trent University).

Nottingham Trent University, Summer Placement

July 2015 - September 2015

Synthesis of Novel Antimalarial Compounds derived from the Codinaeopsin Scaffold.

Supervised by Dr Liam Duffy (School of Science & Technology, Nottingham Trent University).


Awards

2017/2018

First Place Poster Prize Winner at the Molecular Analytical Science Centre for Doctoral Training Annual Conference.

2016/2017

Poster Prize Winner at the Molecular Analytical Science Centre for Doctoral Training Annual Conference.

2015/2016

Winner of the Trent Institute for Learning and Teaching Research in Undergraduate Studies Award. In recognition of having the best research project in the School of Science and Technology in 2015/2016.


Contact Information

Email: R.Tomas@warwick.ac.uk

Linkedin: https://uk.linkedin.com/in/ruben-tomas-63a7519a

Orcid ID: https://orcid.org/0000-0002-7191-2539

MOAC Department, Top floor Senate House, Universty of Warwick, Coventry, CV4 7AL.


MAS 2016

MAS Cohort ChemballMAS Cohort Christmas

Me

Ruben Tomas

MAS CDT

Senate House

The University of Warwick.

Coventry

CV4 7AL

R.Tomas@warwick.ac.uk