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Expert comment from Professor David Greenwood

WMG is delighted at the news that Britishvolt have been purchased by Recharge.Picture of Professor David Greenwood

Professor David Greenwood, Director of Industrial Engagement at WMG, University of Warwick said: “This is great news for the UK, allowing us to capitalise on the value realised under the previous ownership. High value jobs will be protected and created in the UK as a result of this purchase - not just in the company, but in its upstream and downstream supply chains.
 
“For the UK to remain globally competitive, it is critical that we establish a strong battery manufacturing base to support many of our key industrial sectors, including automotive, aerospace, rail, marine and energy storage.”

WMG looks forward to continuing to support the growth of the UK battery industry.

Read more about the news here: https://www.bbc.co.uk/news/business-64754879

Mon 27 Feb 2023, 11:42 | Tags: HVM Catapult People

Flow Rate-Independent Multiscale Liquid Biopsy for Precision Oncology

Liquid biopsies of circulating tumor cells (CTCs) have the potential to transform cancer management through non-invasive, real-time feedback on patient conditions. However, immunoaffinity-based liquid biopsies typically suffer from low throughput, relative complexity, and postprocessing limitations. Here, we addressed these issues simultaneously by decoupling and independently optimizing the nano-, micro-, and macro-scales of an enrichment device that is simple to fabricate and operate. Unlike other affinity-based devices, our scalable mesh approach enables optimum capture conditions at any flow rate. The device detected CTCs under experimental conditions and in the blood of cancer patients where it also allowed for postprocessing and, thus, identification of clinically relevant biomarkers such as HER2, but also has the potential to predict patient response to therapies such as immune checkpoint inhibition therapy in the future. This suggests that our approach can overcome major limitations associated with affinity-based liquid biopsies and help improve cancer management.

Read the paper hereLink opens in a new window.

Fri 24 Feb 2023, 15:22 | Tags: BMS BMS_newpub

From cereus to anthrax and back again: Assessment of the mechanism of temperature-dependent phenotypic switching in the “cross-over” strain Bacillus cereus G9241

Bacillus cereus G9241 was isolated from a Louisiana welder suffering from an anthrax-like infection. The organism carries two transcriptional regulators that have previously been proposed to be incompatible with each other in Bacillus anthracis: the pleiotropic transcriptional regulator PlcR found in most members of the Bacillus cereus group but truncated in all B. anthracis isolates, and the anthrax toxin regulator AtxA found in all B. anthracis strains and a few B. cereus sensu stricto strains. Here we report cytotoxic and haemolytic activity of cell free B. cereus G9241 culture supernatants cultured at 25 °C to various eukaryotic cells. However, this is not observed at the mammalian infection relevant temperature 37 °C, behaving much like the supernatants generated by B. anthracis. Using a combination of genetic and proteomic approaches to understand this unique phenotype, we identified several PlcR-regulated toxins to be secreted highly at 25 °C compared to 37 °C. Furthermore, results suggest that differential expression of the protease involved in processing the PlcR quorum sensing activator molecule PapR appears to be the limiting step for the production of PlcR-regulated toxins at 37 °C, giving rise to the temperature-dependent haemolytic and cytotoxic activity of the culture supernatants. This study provides an insight on how B. cereus G9241 is able to ‘switch’ between B. cereus and B. anthracis–like phenotypes in a temperature-dependent manner, potentially accommodating the activities of both PlcR and AtxA.

Read the paper hereLink opens in a new window.

Fri 24 Feb 2023, 15:21 | Tags: BMS BMS_newpub

The influence of extrachromosomal elements in the anthrax “cross-over” strain Bacillus cereus G9241

Bacillus cereus G9241 was isolated from a welder who survived a pulmonary anthrax-like disease. Strain G9241 carries two virulence plasmids, pBCX01 and pBC210, as well as an extrachromosomal prophage, pBFH_1. pBCX01 has 99.6% sequence identity to pXO1 carried by Bacillus anthracis and encodes the tripartite anthrax toxin genes and atxA, a mammalian virulence transcriptional regulator. This work looks at how the presence of pBCX01 and temperature may affect the lifestyle of B. cereus G9241 using a transcriptomic analysis and by studying spore formation, an important part of the B. anthracis lifecycle. . Here we report that pBCX01 has a stronger effect on gene transcription at the mammalian infection relevant temperature of 37˚C in comparison to 25˚C. At 37˚C, the presence of pBCX01 appears to have a negative effect on genes involved in cell metabolism, including biosynthesis of amino acids, whilst positively affecting the transcription of many transmembrane proteins. The figure below shows the first image of the anthrax G9241 cross-over strain linear chromosome bacteriophage (unusual in bacteriophage itself).

Read the paper hereLink opens in a new window.

Fri 24 Feb 2023, 15:20 | Tags: BMS BMS_newpub

Territorial Bodies: World Culture in Crisis - Introducing Keynote Speaker – Kathryn Yusoff

Writing about web page https://warwick.ac.uk/fac/arts/hrc/confs/territorialbodies/

“Territorial Bodies” Keynotes (1/2): Kathryn Yusoff

When deciding the keynotes for “Territorial Bodies”, we had a number of key considerations in mind. Given the interdisciplinarity at the heart of the conference, we were keen to find keynotes who embraced this interdisciplinarity within their own work. Those academics who are redefining fields, thinking across disciplines, and breaking out of traditional silos were at the top of our list. We were also searching for the keynotes to bring a variety of perspectives on the central notion of “Territorial Bodies”, particularly considering the idea from across social, political and environmental frameworks. Introducing Prof. Kathryn Yusoff, Professor of Inhuman Geography at Queen Mary University of London…

Fri 24 Feb 2023, 14:50 | Tags: Conference Information Blogs

WLS Research Fellows attend the Royal Society Event for British Academy Fellows from Ukraine

On the 15th of February 2023, the Royal Society hosted an event for British Academy Fellows from Ukraine, which was attended by fellows from the WLS research team – Dr Aisel Omarova and Dr Maryna Utkina.

Fri 24 Feb 2023, 11:14 | Tags: Research, Staff in action

Alex Horne praises School Tasking primary outreach project

Taskmaster creator and co-presenter ‘little’ Alex Horne has provided a recorded testimonial about Warwick Law School’s Dr Ali Struthers and the hard work and commitment she has shown to the School Tasking project. “The work that Ali has been doing […] has been genuinely remarkable.” Watch the full video testimonialLink opens in a new window.

Thu 23 Feb 2023, 10:00 | Tags: Impact, Outreach, Feature

Territorial Bodies: World Culture in Crisis: Introducing Keynote Speaker - Dr Lauren Wilcox

Writing about web page https://warwick.ac.uk/fac/arts/hrc/confs/territorialbodies/

“Territorial Bodies” Keynotes (1/2): Lauren Wilcox

When deciding the keynotes for “Territorial Bodies”, we had a number of key considerations in mind. Given the interdisciplinarity at the heart of the conference, we were keen to find keynotes who embraced this interdisciplinarity within their own work. Those academics who are redefining fields, thinking across disciplines, and breaking out of traditional silos were at the top of our list. We were also searching for the keynotes to bring a variety of perspectives on the central notion of “Territorial Bodies”, particularly considering the idea from across social, political and environmental frameworks. Introducing Dr Lauren Wilcox, Associate Professor of Gender Studies at the University of Cambridge...

Wed 22 Feb 2023, 17:30 | Tags: Conference Information Blogs


The ‘mid-life crisis' is more than just a theory, new study finds

People in their midlife are disproportionately more likely to suffer from clinical depression, take their own lives, become dependent on alcohol, have trouble sleeping, and exhibit other extreme-stress ailments.

In the CAGE working paper, ‘The Mid-life Crisis’, Osea Giuntella, Sally McManus, Redzo Mujcic, Andrew J. Oswald, Nattavudh Powdthavee and Ahmed Tohamy use a wide array of population-level health data across all ages to prove that midlife crises are real and affect a high number of people in developed countries.

People in their 40s and 50s in developed countries are typically at their peak earnings and usually have not yet experienced significant illness or disability. Yet, adults in this age bracket report finding it hard to concentrate, say they more likely to forget things, are more likely to suffer from migraines and feel more overwhelmed at work. They are also more likely to suffer depression, develop dependency on alcohol and commit suicide.

The paradoxical association between high living standards and rising dissatisfaction in midlife is yet to be explained. But the findings are a clarion call for policymakers to pay attention to the issue.

The research uses decades’ worth of panel and longitudinal data on health and wellbeing capturing the experience of around 500,000 individuals from developed countries including the UK, USA, France and Australia.

Nine key natural distress indicators were picked from a wide range of surveys including the British household panel survey (BHPS) and the Household Income and Labour Dynamics in Australia (HILDA) survey. These indicators were: suicide, sleeping problems, alcohol dependence, concentration difficulties, memory problems, intense job strain, disabling headaches, suicidal feelings, and extreme depression.

The results drawn from these data sources prove the existence of the midlife crisis. All the markers of distress that were measured followed a consistent trend that peaks between people’s late 40s and early 50s.

Strikingly, the data shows that those in midlife are twice as likely to be depressed than those under the age of 25 or over the age of 65. Suicide rates, the ultimate measure of exceptional distress within a society, were also shown to be the highest among individuals in their early 50’s.

The authors make sense of this by considering the cumulative effect of how smaller issues like poor sleep, headaches and job stress mount up and affect those in middle age over time. For example, panel data from 18,000 Canadians found that migraines peaked in midlife. Migraines were also found to be one of the strongest predictors of extreme depression.

Within-person longitudinal changes in migraines from a sample of over 200,000 people from the BHPS shows a similar trend. The data is controlled for socioeconomic variables including an individual's income and the number of young children they might have. Noticeably, migraines spike at the midlife point, between the ages of 40 and 50.

This peak is found across a fleet of other measures taken by the authors, for example, in reports of alcohol dependence and suicidal thoughts for a one-year period in 2014 from the NHS’s Adult Psychiatric Morbidity Survey (APMS). For the 7,500 recordings taken, the peak observation level is yet again observed at midlife in the 40–50 age bracket. The trend is the same for the other six indicators of distress (suicide, sleeping problems, concentration difficulties, memory problems, intense job strain, and extreme depression) mentioned above.

While no definitive explanation has yet been found to explain the midlife crisis, the authors were able to rule out the effects of income differentials and children.

Intriguingly, the spikes at midlife found in the authors’ data are also found in data relating to our primate relatives, chimpanzees and orang-utans.

Whether midlife crises are caused by societal pressures or are an innate biological phenomenon, the extensive evidence of the midlife crisis across the developed world shows that governments need to start paying attention to what is driving unhappiness in society.

  • Giuntella, O., McManus, S., Mujcic, R., Oswald, A.J., Powdthavee, N., and Tohamy, A. (2022). The midlife crisis. CAGE Working Paper (No. 641).
Wed 22 Feb 2023, 13:35 | Tags: Featured Promoted homepage-news Research

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