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Professor Ioannis Nezis

Supervisor Details

Professor Ioannis Nezis

Contact Details

Professor Ioannis Nezis

School of Life Sciences, University of Warwick

Research Interests

Autophagy is an evolutionarily conserved catabolic process that involves the degradation of cytoplasmic material through the lysosomal pathway. It is a cellular response in nutrient starvation but it is also responsible for the removal of aggregated proteins, damaged organelles and developmental remodeling. Dysfunction in autophagy has been implicated in an increasing number of diseases from bacterial and viral infections to cancer and more recently in neurodegeneration and other ageing-related diseases. Sequestration and degradation of cytoplasmic material by autophagy can be selective through receptor and adaptor proteins. We are using mammalian cells in vitro and the fruit fly Drosophila melanogaster, as a genetically modifiable model organism to investigate the mechanisms of autophagy and selective autophagy in the context of the physiology of the cell, the system and the living organism. We are particularly interested to study selective autophagy in the context of ageing, neurodegeneration, obesity, infections and tumorigenesis.

Scientific Inspiration

Terje Johansen. He discovered the molecular basis of selective autophagy.


Project Details

Prof Nezis is the supervisor on the below projects:


Previous Projects

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