Dr Séamus Holden
Supervisor Details
Research Interests
My lab uses advanced microscopy to figure out how bacteria grow and divide. We study how proteins act as tiny nanoscale machines to build complex biological structures, with a particular focus on how bacteria remodel their cell envelope, which is one of the most important targets for antibiotics. To achieve this we use single molecule microscopy to follow the activity of individual proteins at nanoscale resolution inside live bacteria.
Scientific Inspiration
Uri Alon (https://www.weizmann.ac.il/mcb/UriAlon/) is a fearless interdisciplinary scientist who works across physics and biology, making significant contributions across multiple fields. Uri communicates science passionately with humour and songs - his science songs are well worth looking up on YouTube. His book, Introduction to Systems Biology, was the first to really convince me that reductionist physical principles can be genuinely useful in biology, and played a big part in inspiring my approach to research.
MIBTP Project Details
Previous Projects (2024-25)
Primary supervisor for:
Co-supervisor on a project with Professor David I Roper FRSC.
Previous Projects (2023-24)
Primary supervisor for: