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Dr Seamus Holden

Associate Professor


Phone: 024 765 75794

Office: IBRB2.28

Twitter: @seamus_holden 

Holden lab website

Research Clusters

Microbiology & Infectious disease

Quantitative, Systems & Engineering Biology

Vacancies and Opportunities

For PhD and postdoctoral opportunities, and interest in potential collaborations, please contact me at the above email address.

Research Interests

My lab uses advanced microscopy to figure out how bacteria grow and divide. We study how proteins act as tiny nanoscale machines to build complex biological structures, with a particular focus on how bacteria remodel their cell envelope, which is one of the most important targets​ for antibiotics. To achieve this we use single molecule microscopy to follow the activity of individual proteins at nanoscale resolution inside live bacteria

Research: Technical Summary

My lab studies biophysical principles of bacterial cell wall biosynthesis, with a particular focus on the mechanistic principles of bacterial cell division and elongation. We work primarily with the Gram-positive model organism Bacillus subtilis.  To tackle these questions my lab develops novel experimental methods based on single molecule & super-resolution fluorescence microscopy, microfabrication and microfluidics. I am a strong supporter of open science, and work to ensure that all of the software, methods and resources that my lab develops are freely available and easy to use.

About the lab

We are a diverse interdisciplinary lab combining approaches from molecular microbiology, physics, microscopy and data science. We are funded by the Wellcome Trust and BBSRC, and work with multiple national and international collaborators, including David Roper (SLS), Phill Stansfeld (SLS) at Warwick, and colleagues in Belfast, Newcastle, Cambridge, Austria and Australia.

Job/ studentship opportunities

If you would like to discuss any of the opportunities below, please send an email to, with CV.


Post-doc position in in vitro single molecule biophysics and super-resolution microscopy. Application deadline: 21 Nov 2023.

Senior Research Technician in biochemistry and molecular biology - post is joint with David Roper lab. Application deadline: 21 Nov 2023.

PhD and MBio students

We are happy to recruit PhD students via either the BBSRC MIBTP programme or the Warwick MRC DTP programme. We can also host MBio projects from the School of Life Sciences undergraduate degree programmes

I am very happy to supervise interdisciplinary projects to students from a range of training backgrounds such as biology, biochemistry, physics.

Undergraduate research projects

See "Teaching/ Student supervision" tab below.

  • 2022: Moved to University of Warwick as Associate Professor (Reader).
  • 2020: Awarded British Biophysical Society Louise Johnson Early Career Award
  • 2018: Promoted to Principal Research Associate, Newcastle University.
  • 2017: Awarded Wellcome Trust & Royal Society Sir Henry Dale Fellowship.
  • 2015: Moved to Newcastle University to start independent research career.
  • 2012: Awarded Marie Curie Intra-European Fellowship
  • 2011-2015: Post-doctoral Researcher in laboratory of Professor Suliana Manley, EPFL, Switzerland,
  • 2007-2011: DPhil in Biological Physics in laboratory of Professor Achilles Kapanidis, University of Oxford
  • 2003-2007: Studied Physics, University of Oxford