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HAT Modelling and Economic Predictions for Policy (HAT MEPP)

Human African Trypanosomiasis Modelling and Economic Predictions for Policy (HAT MEPP) is a 3-year research project started in 2018 (to 2021), funded by the Bill and Melinda Gates Foundation (BMGF), to support global efforts to eliminate gambiense Human African Trypanosomiasis (gHAT or sleeping sickness). Sleeping sickness is a tropical disease found in West and Central Africa, transmitted to humans by tsetse (biting flies), that is typically fatal without treatment. To date, interventions have reduced sleeping sickness cases to historically low levels and the World Health Organisation (WHO) has set a goal to eliminate transmission of the infection by 2030.

The purpose of the HAT MEPP project is to provide novel, quantitative evidence to support gHAT control and elimination by carrying out complex modelling. The results will help identify where intensified interventions are needed (especially small administrative regions within countries) to achieve elimination of transmission (EOT) and support planning of optimum intervention strategies, including cost considerations in conjunction with disease burden estimates. The HAT MEPP project combines the research expertise of mathematical modellers, health economists, epidemiologists and a software developer.

Project aims:

To provide decision support to national programmes in Democratic Republic of Congo, Chad, Cote d’lvoire, Guinea and Uganda regarding intervention strategies and cost effectiveness, taking into account resource constraints.

To deliver an elimination investment case (EIC) for the Bill and Melinda Gates Foundation (BMGF) to understand the feasibility and associated costs of elimination of transmission of gHAT.

Support analyses of on-going Trypa-No! and TrypElim (gHAT elimination) programmes, including cost, new diagnostics and interventions.

Current work

Work is currently underway on:

  • Disease transmission modelling and projections
  • Optimising elimination intervention strategies and cost
  • A data and analysis tool
  • New diagnostics and interventions
See current work, project results and publications for further information


Project Team

Principal Investigator (PI):

Kat Rock

Warwick project team:

Matt Keeling
Jason Madan
Ron Crump
Ching-I Huang
Xia Wang-Steverding
Paul Brown

Project management:

Anna Dunkley
Sukhwinder Soggi

External project team:

Fabrizio Tediosi (Swiss TPH)
Marina Antillon (Swiss TPH)
Deirdre Hollingsworth (Oxford)

HAT researchers in Guinea

HAT researchers in Guinea