Our research covers these main areas of synthetic chemistry

 

Organic Synthesis

1. New methodology and application to target synthesis using free radicals.
2. The asymmetric chemistry and rotation dynamics of atropisomeric enamides
3. The use of CuSO₄ as a catalyst in carbon/carbon bond formation.

Sustainability, renewable and materials chemistry

1. Renewable feedstocks and waste streams for the chemical and polymer industries.
2. Renewable polymers, composites and materials
3. Renewable non-stick and surface coatings

Chemical Biology and Medicinal Chemistry

1. The application of chemical genetics tools to help in determining drug/receptor interactions
2. The synthesis of novel beta- and gamma-lactams as antibiotics
3. The synthesis of novel imaging agents

Instrumentation

1. The development of novel free radicals for DNP-Enhanced Solid State MAS NMR.
2. The development of programmable flow devices to evolve target compounds with pre-determined properties.
3. Development of new chiral phases for chiral HPLC and flash chiral chromatography.

CHEMICAL BIOLOGY AND Tangent Reprofiling.LTD 2008-11:

(Key Papers: 1) Mol. Biosyst. 2011, 7, 116. , 2) ChemMed, 2008, 3, 372

 Our Magic-Tag^® technology (funded by BBSRC grant GR88/EGM17690) has recently been used to discover a putative interaction between β₂-adrenoreceptor agonists and ATF4. A description of the technology can be found here (ChemCommun 2007, 2808).

 

   

 Recent published papers in this area

1. Using the Man(9)(GlcNAc)-DC-SIGN pairing to probe specifity in photochemical immobilisaition. S. J. Dilly, A. J. Clark, D. A. Mitchell, A. Marhs, P. C. Taylor, Molecular Biosystem, 2011, 7, 116
2. Rapid Identification of a Putative Interaction between b2-Adrenorecpetor Agonsits and ATF4 using a Chemical Genomics Approach, S. R. Ladwa, S. J. Dilly, A. J. Clark, A. Marsh, P. C. Taylor, ChemMedChem, 2008, 3, 372.
3. Peptide / Protien identification using photoreactive carriers for immobilisation of the ligands. A. J. Clark, S. J. Dilly, A. Marsh, R. Napier, P. C. Taylor, Patent, 2007, WO/2007/020453, PCT/GB2006/003089
4. Function and Stability of Abscisic Acid Acyl Hydrazone Conjugates by LC-MS2 of ex vivo Samples. T. Smith, A. J. Clark, R. Napier, P.C. Taylor, A. J. Thompson, A. Marsh, Bioconjugate Chemistry 2007, 18, 1355-1359.
5. A Photoimobilisation Strategy that Maximises Exploration of Chemical Space in Small Molecule Affinity Selection and Target Discovery. S.J. Dilly, M. J. Bell, A. J. Clark, A. Marsh, R. Napier, M. J. Sergeant, A. J. Thompson, P.C. Taylor, Chem. Commun, 2007. 2808-2810.