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Professor Sebastien Perrier

Professor Sebastien Perrier
Department of Chemistry, University of Warwick
Sébastien graduated with his PhD in 2002 from the University of Warwick, England, in polymer chemistry. After one year as a postdoctoral fellow at the University of New South Wales, Australia, he was appointed as a lecturer at the University of Leeds, UK. In October 2007, he moved to the University of Sydney and was appointed as director of the Key Centre for Polymers & Colloids. Sébastien leads a team of 15-20 researchers working on the design of a wide range of state-of-the-art functional polymeric materials by careful manipulation of their molecular structure. He is a member of the editorial boards of the journals Soft Matter, Macromolecules, European Polymer Journal and Polymer Chemistry, a member of the RACI Polymer Division executive committee (2011 Chair), and was appointed on the Australian Research Council College of Experts in 2011. Awards include the Macro Group UK Young Researcher Award (2006), the Young Tall Poppy Science Award (2009), the Rennie Memorial Medal (2009), the David Sangster Polymer Science and Technology Award (2009), the Le Fèvre Memorial Prize (2013) and the RS Wolfson Award (2014).

Courses Taught

  • CH272, CH404 undergraduate module.
  • CH161 Organic Chemistry tutorials.
  • CH967 and CH974 MSc modules.

Contact Information

Assistant Professor

Dr Santhosh Kalash Rajendrakumar

Santhosh Kalash Rajendrakumar got his bachelor’s degree in biotechnology and master’s degree in Molecular Medicine from India. With a fellowship from Brain Korea 21 (BK21), he completed his PhD in Biomedical Sciences from Chonnam National University, Gwangju, South Korea, in 2019. Later that year, he joined as a postdoctoral research associate in the Department of Medicine, Renal Division at Brigham and Women’s Hospital/Harvard Medical School. Then in 2020, he moved to Tufts University, Massachusetts, United States, to work on lipidoid nanoparticles for mRNA delivery in lung cancer. In 2021, he joined the Perrier research team as an Assistant Professor (research) to develop RAFT polymeric nanoparticles for cancer immunotherapy and anti-inflammation. Dr Santhosh Kalash Rajendrakumar

Address: Department of Chemistry, University of Warwick

 

Research Interests

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Postdoctoral Researchers

Dr Sophie Hill

Sophie graduated from the University of Manchester with a degree in Chemistry with Medicinal Chemistry (MChem) in 2018. Her Master's project was completed under the supervision of Dr Simon Webb and investigated self-assembly of sulphur based lipids for the examination of prebiotic evolutionary concepts. She recently started her PhD under the supervision of Professor Sebastien Perrier on a collaborative project with AstraZeneca, focusing on cyclic peptide-polymer conjugates and their applications for drug delivery. Dr. Sophie Hill

Address: Department of Chemistry, University of Warwick

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Dr Valentin Beyer

Valentin received his MSc degree in Chemical Biology from the Karlsruhe Institute of Technology in Germany. He then moved to the UK to undertake his PhD studies with Dr Remzi Becer at Queen Mary University of London and the University of Warwick. Following his PhD degree, he moved to the KU Leuven in Belgium as a postdoctoral researcher in the group of Prof. Wim Thielemans, working on biodegradable plastics. Since April 2023, Valentin is a research fellow in the Perrier Group investigating the synthesis of novel polyester materials for a broad range of applications. Dr. Valentin Beyer

Address: Department of Chemistry, University of Warwick

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Dr Min Zeng

Min completed his bachelor's degree in Polymer Materials and Engineering at the Hefei University of Technology. He then went on to obtain his PhD at the Tsinghua University under the supervision of Prof. Jinying Yuan, which focused on polymerization-induced self-assembly (PISA), stimuli-responsive polymers and self-assembly of block copolymers. In 2022, Min joins the Perrier group as a post-doctoral researcher to work with supramolecular cyclic peptide-polymer conjugates. Dr. Min Zeng

Address: Department of Chemistry, University of Warwick

Dr Pooja Agarwal

Pooja Agarwal completed her PhD in 2016 from Central Drug Research Institute, India, after getting a fellowship from the Council of Scientific and Industrial Research(CSIR, India). She worked under the supervision of Dr. Manju Yashoda Krishnan and mainly focused on the persistence of Mycobacterium tuberculosis(Mtb) in adipose tissue. After completing her PhD, she joined as a postdoctoral fellow with Prof Valerie Mizrahi at the University of Cape Town, South Africa. There she worked on a project involving Mtb and its interaction with foamy macrophages. During her postdoc, she got Santander Universities Mobility Award to work with Dr Fernando Martinez Estrada as a part of a collaboration at the University of Surrey, United Kingdom. She also got selected for Oppenheimer Fund - Academic Exchange programme to support her visit at the University of Oxford, the United Kingdom, with Prof Siamon Gordan. She joined the University of Warwick in 2022 as a Research Fellow in the Monash Warwick Alliance-AMR Training Programme in Emerging Superbug Threats to work on an interdisciplinary project. She jointly works with Prof Sebastian Perrier and Dr Meera Unnikrishnan (Medical School). Here, she will work on a project that aims to develop novel nanoparticle-based approaches to target intracellular human pathogens like Mtb and Staphylococcus aureus using relevant in vitro and in vivo infection models. Dr. Pooja Agarwal

Address: Department of Chemistry, University of Warwick

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Dr Joaquin Sanchis-Martinez

Joaquin Sanchis-Martinez graduated in Chemistry from the University of Valencia (Spain) and obtained his PhD in Organic Chemistry in 2005 in the group of Prof. Ana Costero in the same University. After his doctoral degree, he held a contract research position at BASF AG (Ludwigshafen, Germany). In 2006, he joined Max-Planck-Institut für Kohlenforschung (Mülheim and der Ruhr, Germany) as a post-doctoral researcher in the group of Prof. Manfred Reetz, focusing on Biocatalysis and Enzyme Engineering by directed evolution. In 2009, he started developing polymer-drug conjugate nanomedicines with application in the treatment of cancer at the Prof. Maria Vicent’s Polymer Therapeutics Lab in the Biomedical Research Center Principe Felipe (CIPF) in Valencia (Spain). In the same year, he visited Prof. Carlos Barbas III in The Scripps Research Institute (La Jolla, CA, US) for a 3-month training period in the synthesis and characterization of Zinc Fingers. In 2011, he combined his position at CIPF with a part-time associate lecturer appointment at the Faculty of Chemistry at the University of Valencia. In 2014 he joined the group of Prof. Sébastien Perrier as a Research Fellow and is now involved in the University of Warwick – Monash University alliance, leading Prof. Perrier’s research team in Melbourne. His research interest focuses on the application of functionalized tubular structures as carriers for drug-delivery to selective tissues or biological compartments in the human body. Dr Joaquin Sanchis-Martinez

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Final Year PhD Students

Hannah Burnage

Hannah completed her BSc in Biochemistry at the University of Warwick in 2018. She then started the MAS CDT course and completed her Master’s in 2019. Her thesis research project was focused on using GPC to monitor polymerisation reactions, under the supervision of David Haddleton. In 2019 she began her PhD under the supervision of Sébastien Perrier making and characterising nanoparticles. Hannah Burnage

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Vito Kontrimas

Vito graduated with MPharm degree at the Reading School of Pharmacy in 2016. His thesis focus was to investigate the in-vitro effect of carbon monoxide on Alzheimer’s disease. After graduation, Vito also completed his pharmacy pre-registration training at the Oxford University Hospitals NHS Trust, before joining MRC DTP in IBR course at the University of Warwick to pursue his academic interests. During the MRC DTP in IBR course, Vito has been involved in two mini-projects: 1) “pH-responsive polymeric nanoparticles for drug delivery” in Perrier’s group 2) “The impacts of daratumumab kinetics in Multiple Myeloma” supervised by Prof. Mike Chappell. Recently, Vito has joined the Perrier group as a PhD to work on the development of multifunctional polymeric drug delivery systems for penetrating the blood-brain barrier. Vito Kontrimas

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Magda Beres (Przybyla)

Magda completed her BSc at the University of Warwick in 2020. During her studies, she undertook a summer project in the Perrier group working on 4-vinylbenzyl chloride macroinitiator for the synthesis of POx brushes. The following summer she joined Waterfield group at Warwick Medical School to work on reconstituting bacterial injection systems for use in drug delivery. In September 2020 Magda started her PhD under the supervision of prof. Sébastien Perrier, sponsored by Lubrizol. Magda’s project will focus on RAFT iniferter polymerisation. Magda Beres (Przybyla)

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Sophie Laroque

Sophie completed her bachelor and master degree in chemistry at Humboldt University. For her bachelor thesis, she investigated the triple helix formation of collagen mimetic peptides, under the supervision of Prof. Hans Boerner. Afterwards, she spent 6 months at Warwick University for a research internship as part of her master degree in the group of Sebastien Perrier, working on emulsion polymerisation and polymerisation-induced self-assembly to generate pH-responsive nanoparticles. Finally, for her master thesis, she worked under the supervision of Dr. Matthias Hartlieb and Prof. Alexander Boeker at Potsdam University and Fraunhofer Institute for Applied Polymer Research on the synthesis of antimicrobial bottle brush polymers. In 2020 she started her PhD under the supervision of Sébastien Perrier and Katherine Locock (CSIRO), working on antimicrobial star polymers. Sophie Laroque

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Meshari Alqarni

Meshari completed his MSc at the University of Warwick in 2020. He carried out his Master’s project under the supervision of Dr Remzi Becer which his thesis research project was focused on Single Chain Polymer Nanoparticles (SCNP). Recently, Meshari has joined the Perrier group as a PhD to work on encapsulation of nanoparticles by RAFT polymerization in non-polar solvent. Meshari Alqarni

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Lena Dalal

Lena completed both her bachelor degree in Pharmacy and Pharmaceutical Chemistry and her Masters in Industrial Pharmacy at Damascus University, Syria. She performed an internship at UNIPHARMA pharmaceutical Industries while attending her degree. Lena is also a registered pharmacist in Syria, participated in many national conferences, and worked as a full-time teaching staff at Arab International University, Syria. She recently published her master thesis at Scientific Reports on the use of Self-nanoemulsifying drug delivery systems to enhance drug solubility. Lena recently started her PhD under the supervision of Professor Sébastien Perrier to explore the prospects of various polymers as novel antifungal agents. Lena Dalal

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Iona McIntyre

Iona graduated with a BSc Biochemistry degree from the University of Warwick in 2020. After graduation, Iona joined the MRC DTP Interdisciplinary Biomedical Research course at Warwick Medical School as an iCASE student working in collaboration with her industry partner, Ferring Pharmaceuticals. Iona’s iCASE project is a four-year MSc and PhD titled “Modifying macrophage phenotype as a potential treatment for endometriosis”. During her MSc year, Iona worked on two introductory research projects to begin this work: 1) Treating endometriosis at the nanoscale: nanovectors for macrophage targeting and drug delivery, supervised by Prof Sébastien Perrier and 2) Modifying macrophage phenotype as a potential treatment for endometriosis, supervised by A/prof Erin Greaves. Iona’s current work involves using macrophage immunotherapies, polymeric nanoparticles and bioinformatics; to develop novel therapeutics for endometriosis. Iona McIntyre

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Ola Alkosti

Ola completed her bachelor's degree in pharmacy and pharmaceutical chemistry at Damascus University in 2015. Her undergraduate studies have enriched her laboratory skills, including spectrophotometer, Immunoassays (ELISA), western blotting and different types of chromatography. She has built her experience by being involved in the working sector as a pharmacist in a big hospital for more than 3 years. Believing that teaching is a main skill that every researcher needs to build, she was chosen to be the scientific supervisor in the pharmaceutical lab at Damascus University and was also accepted to be training in the medical laboratories in one of the best academic hospitals in the country.

She obtained her master’s degree in pharmacology and drug discovery from Coventry University. Her dissertation project was supervised by Dr. Christopher J Mee, understanding the role of VEGF-C and CCL-19 in the metastatic process of hepatocellular carcinoma. Different techniques were used in this project such as flowcytometry, MTT assay and Real-time PCR.

Her PhD is about engineering immune cells surfaces under the supervision of Professor Matthew Gibson. We will be using polymers to reprogram the cells to fight diseases, particularly cancer.

Ola Alkosti

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Second Year PhD Students

Esther Udobang

A first-class BSc. graduate from Bells University of Technology in Nigeria, Esther joins the Perrier group for her doctorate research on synthesis of polymeric nanoparticles as delivery solution in gene therapy. Her interest in this area stems from her Master's research in Biosynthesis of silver nanoparticles as novel antimicrobial agents targeting a selection of multidrug resistant strains of bacteria, and thus research has been published in a reputable journal. Esther Udobang

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Tasha Reddy

Tasha completed her BSc with Professional Training Year (PTY) in Medical Sciences at the University of Exeter in 2021. Her PTY placement was with the Islet Biology Exeter team under the supervision of Dr Mark Russell. Her dissertation under the supervision of Dr Tetsu Kudoh. She joined the University of Warwick in 2021 on the MRC DTP in IBR course. During the MSc Tasha completed 2 mini-projects;

1) In the Perrier group synthesising cationic polymers to exert antimicrobial effects,

2) In the Crow group investigating a novel tripartite efflux pump.

In 2022 Tasha started her PhD under the supervision of Professor Sébastien Perrier and Dr Freya Harrison. Her project will use an interdisciplinary approach combining polymer chemistry and microbiology to explore synergetic polymer/antibiotic systems for the treatment of biofilm infections.

Tasha Reddy

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Alexandre Soares Gomes

Alex completed his MChem at Durham University in 2022. During his final year, he undertook an industrial placement at the Lubrizol Corporation under the supervision of Dr Nathan Bartlett and Dr William Barton working on the development of ashless antioxidants for application in automotive and industrial lubricants. In October 2022 Alex started his PhD under the supervision of Prof. Sébastien Perrier as part of a collaborative EPSRC Prosperity Partnership project between Lubrizol and the Universities of Warwick and Nottingham. Alex’s project will focus on polymer synthesis in continuous flow reactors. Alexandre Soares Gomes

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Mingchao Li

Mingchao completed his master's degree in Biomedical Engineering at the South China Normal University, which focused on the development of brain gene delivery systems for Parkinson disease. The systems were designed based on the blood brain barrier (BBB) mechanisms to transport gene across the BBB into brain. The gene vectors include magnesium oxide, zinc oxide and ferric oxide. He then worked for a biotech company as a senior project director where he was responsible for clinical project development and clinical trial operations. In 2022, Mingchao joins the Perrier group as a PhD to work on polymeric nanoparticles and their applications for drug delivery. Mingchao Li

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First Year PhD Students

Jiuli Xu

Jiuli obtained his Bachelor’s degree in Chemistry at the University of Warwick in 2022. At the same year, Jiuli starts his Master by Research under the supervision of Professor Sébastien Perrier, and successfully finished his master by research degree with thesis titled Photolytic Degradation of RAFT Agents in the Polymerisation of Nitrogen Containing Monomers, He has rejoin the group, focus on the research of presenting a simple supramolecular strategy by cyclic peptide to develop ultra bright cyanine-based fluorescent materials by addressing long-standing challenges associated with cyanine dyes. Jiuli Xu

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Yixuan Chen

Yixuan completed his degree at the University of Birmingham, from 2019 to 2022. Then he moved to study a MSc at the University of Warwick. He carried out his MSc project under the supervision of Professor Sébastien Perrier on synthesis of cyclic-peptide conjugates with hydrophobic linker group. Recently, Yixuan joined the Perrier group as a PhD student, focusing on the synthesis of oil soluble nanoparticles. Yixuan Chen

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Master Students

Kartik Thite

Kartik graduated from University of Warwick in 2023 with BSc in Chemistry. In 2024 he joined the Perrier group as a Masters by Research student. Kartik's project focuses on incorporating a condition sensitive cleavable linker in a cyclic peptide-polymer conjugate system. Kartik Thite

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