AMPLIFY: Advancing Membrane Protein Learning for Improved Factorial Yield
AMPLIFY: Advancing Membrane Protein Learning for Improved Factorial Yield
Membrane proteins are vital for cellular function and are targets for over 50% of modern pharmaceuticals. Despite their importance, producing these proteins at scale remains a major challenge.
Here we aim to AMPLIFY the production of membrane proteins through cutting-edge metabolic and molecular modelling tools. This project combines state-of-the-art protein engineering with AI-driven analysis to optimise yields and study protein stability.
By mastering these techniques, you’ll contribute to breakthroughs in biomedical research and drug development, gaining invaluable skills in membrane protein science and computational (bio)chemistry. Join us to tackle this global challenge and AMPLIFY your scientific expertise.
Supervisors
Primary: Prof. Phillip Stansfeld, Chemistry
Dr Alex Darlington, Engineering
A transcript of the video is available by clicking this link - transcript opens in another windowLink opens in a new window
Membrane proteins are critical for functions like nutrient transport, signal transduction, and energy conversion in cells. However, their hydrophobic nature and complex structure make them notoriously difficult to express and purify. Our AMPLIFY project aims to address these challenges by developing innovative methods to improve membrane protein yields, ensuring they retain their functional integrity. You’ll work at the cutting edge of structural biology, employing computational techniques to tackle real-world problems in protein science.
Through this project, you’ll learn to design optimal cell factories for membrane protein production, using AI-driven models to predict and improve protein stability and expression. This multidisciplinary approach will prepare you for diverse career opportunities in academia, industry, and beyond.
By joining this project, you’ll contribute to advancements in engineering biology and gain experience in solving one of the most pressing challenges in pharmaceutical science. Whether you’re fascinated by molecular mechanisms or intrigued by the potential of AI, AMPLIFY offers a unique chance to learn and apply cutting-edge methods that are having real-world impact.
How to apply
This is a fully-funded 4-year PhD position based in the HetSys Centre for Doctoral Training at the University of Warwick. All applications must be made through the University's postgraduate application form with a deadline of 20 January 2025. Please see our How to ApplyLink opens in a new window page for further details on the application process. For further information about student funding, the integrated HetSys training programme and what life is like in the HetSys CDT, please visit the Study with Us page.