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OSS Lab

OSS Lab

Welcome to the OSS Lab

Headed by Orkun S. SoyerLink opens in a new window, the current focus of the OSS lab is to develop a quantitative understanding of cellular metabolism and metabolic interactions among species.

On the former topic, we develop theoretical 'toy' models of key motifs in cell metabolism and conduct experimental analyses on single cell physiology in yeast and mammalian cells. On the latter topic, we create model ('synthetic') microbial communities and study species co-existence and interactions in these. These efforts currently focus on a 15-species cyanobacterial microbial community that develops extensive spatial organisation.

Current key areas of research

1. Emergence and evolution of metabolic excretions and interactions in microbes (funded by NSF/BBSRC) (in collaboration with Wenying ShouLink opens in a new window).

2. Species co-existence and metabolic interactions in spatially organised microbial communities (funded by Gordon and Betty Moore FoundationLink opens in a new window).

3. Relations between membrane potential, redox cycles, and metabolic fluxes (in-between funding - previously funded by Cancer Research UK).

4. Bistability mechanisms in metabolism (in-between funding) (in collaboration with Elisenda FeliuLink opens in a new window and Alex FletcherLink opens in a new window).

5. Mechanisms of metabolic interactions among soils microbes and plants (in-between funding).

For additional information please see our ResearchLink opens in a new window, PublicationsLink opens in a new window, and Pre-PrintsLink opens in a new window pages. You can access code/software from our GitHubLink opens in a new window page and we have started to use Protocols.ioLink opens in a new window to make our lab protocols easily available (more will be added over the next few months).

See also our current and past collaborative projects on bioelectricity: Bio-Electrical Engineering Innovation HubLink opens in a new window, anaerobic microbial communities: Engineering Synthetic Microbial Communities for Biomethane ProductionLink opens in a new window, and temporal metagenomics: Monitoring UK Anaerobic Digestion MicrobiomesLink opens in a new window.

Our Funders

betty moore logo

BBSRC 2019 logo

CRUK logo

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News

New Pre-print (December 2022)

Check out our new pre-print at BioRxiv, 'Reproducible spatial structure formation and stable community composition in the cyanosphere predicts metabolic interactions' by Duxbury et al. LinkLink opens in a new window.

INI workshop (October 2022)

OSS lab was among main organisers and was in attendance at the recent microbial communities workshop at the Isaac Newton Institute (INI). For recorded talks from the event, please see: https://www.newton.ac.uk/event/umcw06/. The event was sponsored by INI and the Gordon and Betty Moore Foundation.

New Theory Pre-print available online (October 2022)

'Co-substrate pools can constrain and regulate pathway fluxes in cell metabolism' by Robert West, Hadrien Delattre, Elad Noor, Elisenda Feliu andOrkun S Soyer. bioRxiv linkLink opens in a new window

PhD viva success (July 2022)

Congratulations, Dr Kelsey Cremin!

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