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Age at Onset, Mortality, and Life-Year Lost for 5 Cardiovascular Disease Conditions: Differences by Ethnicity and Diabetes Status

Leads: Dr Claire Lawson, Prof Kamlesh Khunti (ARC EM), Dr Katharine Reeves, Dr Hannah Crothers, Ms Sandra Remsing (Meths)

Public contributors linked to the ARC WM Research Methods theme will work with the project leads to maximise impact of this study.

Dates: June 2020 - June 2021

Background:

Compared to other ethnicities, South Asians have remarkably higher risks of diabetes and cardiovascular diseases (CVD). Diabetes is about three times more prevalent in South Asians than in White Europeans and occurs over a decade earlier. South Asians with diabetes are also at increased risk of diabetes complications and have a higher mortality rate from coronary heart disease and stroke.

Overall, the incidence of myocardial infarction and stroke have declined rapidly during the past few decades but rates are still higher in people with diabetes compared to those without. However, it remains unclear whether the difference between diabetes and non-diabetes equally applies in South Asians and White Caucasians.

This study will contribute to the evidence on health inequalities related to ethnicity by diabetes status and will help personalise guidelines and support health care professionals in treatments of cardiometabolic diseases.

Policy and Practice Partners:

None, see below.

Co-Funding Partners:

TBC.

Aims and Objectives:

To investigate contemporary trends by ethnicity of several cardiovascular outcomes and life expectancy in people with and without type 2 diabetes (T2DM).

Methods:

The study will be an open cohort of adult patients with a qualifying in-hospital CVD event, with an index date between 2000 and the present. Data will be obtained from the Hospital Episodes Statistics database. Patients with a first in-hospital T2DM diagnosis on or before the index CVD event will comprise the T2DM+ group (exposed); those without will comprise the T2DM- group (unexposed).

Results:

Forthcoming.

Conclusion:

Forthcoming.

Implications for Implementation:

Further evidence of different outcomes by ethnic group requiring systemic action across the health services.