Background:

Annually, over 90,000 people suffer an out-of-hospital cardiac arrest (OHCA). Approximately, a third of these receive resuscitative treatment from ambulance clinicians and less than 10% of these survive and leave hospital to go home. Little is known of what happens to patients following admission into hospital and after discharge. The outcomes of patients after discharge from hospital have not been extensively studied, however, individual studies include relatively small numbers of survivors with little information on their health over the course of time.

Three large clinical studies (AIRWAYS-2, PARAMEDIC, PARAMEDIC-2) have collected information on over 20,000 patients who have had a cardiac arrest in UK. Data collected includes a 6-12 month period following the OHCA. By combining the data from the three studies using meta-analysis, as well as other statistical techniques, will allow for the assessment of the journey of patients from the point they have their OHCA through to 12 months.

Policy and Practice Partners:

Ranjit Lall, CTU, UoW

Stavros Petrou, University of Oxford

Jerry Nolan, Royal United Hospitals Bath NHS Foundation Trust & Resuscitation Council UK

Jonathan Benger, University of the West of England & NHS Digital

Co-Funding partners:

Resuscitation Council UK

Aims and Objectives:

The aim of this study is to carry out an individual patient data of common clinical and health economic outcomes presented in three large UK-based NIHR HTA funded randomised controlled clinical trials for OHCA. These trials are AIRWAYS-2, PARAMEDIC and PARAMEDIC-2.

Methods:

Using data collected on nearly 22,000 patients participating in the three trials the meta-analysis will investigate survival, ROSC at hospital handover, neurological and functional outcomes, health-related quality of life, lengths of hospital stay and economic outcomes.

Main Results:

Ongoing

Conclusions:

N/A

Implications for Implementation:

This study will be of importance to patients and the NHS as it will be the first, comprehensive summary of medium-term outcomes after out-of-hospital cardiac arrest.