Increasing Physical activity in Older People with joint Pain (iPOPP)

Physical activity levels in older people with chronic musculoskeletal pain are low. Lower activity levels are associated with increased pain and disability. Walking is a straightforward way of increasing physical activity, which is accessible, inexpensive and low impact. 

iPOPP is a three-arm randomised controlled trial which aims to test whether a brief behavioural intervention increases average step count compared to usual primary care or receiving a pedometer and activity diary in the post in adults aged 65 years and over with chronic musculoskeletal pain.

We are looking for approximately 57 practices to take part in the study. We need a practice population size of 400,000 within the West Midlands in order to recruit a total of 1,085 patients. Each practice will provide approximately 20 participants.

T2T in Gout

A study to look at what is the clinical and cost effectiveness of using a goal-directed allopurinol-based treat-to-target protocol in people with recurrent gout flares. Patients will be randomised to either: A: Treat to Target ULT or B: Usual GP care

IMPPP - Improving Medicines use in People with Polypharmacy in Primary Care

IMPPP is a large randomised clinical trial looking at how practice pharmacists and GPs, with the help of a new computer tool, can work together to improve the use of medicines in patients who are prescribed multiple medications in primary care.

ATTACK (ASPIRIN TO TARGET ARTERIAL EVENTS IN CHRONIC KIDNEY DISEASE)

is a pragmatic multicentre open-label randomised controlled trial to determine whether the addition of low-dose aspirin to usual care reduces the risk of major vascular events in people with chronic kidney disease (CKD) who do not have pre-existing cardiovascular disease (CVD). This is a very simple study, with a very low workload for participating practices.

Colour COPD – Sputum colour charts to guide antibiotic self-treatment of acute exacerbation of COPD

Colour COPD is a pragmatic multicentre, randomised controlled trial to determine whether the addition of a sputum colour chart to the existing self-management plan provided to patients with COPD improves their use of antibiotics and steroids and reduces the number of exacerbations they experience in a 12 - month period. This is a very simple study, with a very low workload for participating practices.

The ERICA study is a large randomised controlled trial assessing the clinical and cost effectiveness of six electronic risk assessment tools (eRATs) for bladder, kidney, lung, colorectal, ovarian and oesophago-gastric cancers in general practice. We will recruit 530 English practices to compare the effect of eRATs (vs usual care) on: cancer staging at time of diagnosis, cost to the NHS, patient experience of care, and service delivery.