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Translating Knowledge into Practice

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Theme D

1) Title: Supervised Pulmonary Hypertension Exercise Rehabilitation (SPHERe) trial

Principal Investigator: McGregor

Co-investigators: Seers K Bruce, J Underwood, M, Singh, Sally, Taylor, S Banerjee, Bowater, Clift,P Fitzmaurice, D Pincus T, Sandhu H, Mason J, Ji C, Lall, R Robertson E.

Funding NIHR HTA£1,328,000 for 39 months from 1/6/19-31/08/2022


2) Title: Improving the wellbeing of people with opioid treated chronic pain. (i-WOTCH).

Principal Investigator: Sandhu

Co-Investigators: Seers, Haywood, Lall, Tange, Underwood (Warwick), Furlan, A (UHN Canada), Rahman, A (UCL), Carnes D (QMUL), Tysall C (lay), Bee S (lay), Abraham, C (Exeter), Taylor S (QMUL), Manca A (UoYork), Iglesias Urrutia, C (UoYork), Eldabe S (South Tees NHS Trust).

Funding: NIHr HTA Programme. £1,611,457 for 39 months from September 2016


3) Title: Development of Individual Supported Employment work-placements to improve health related Quality of Life of people with chronic pain who are unemployed. (RISE).

Principal Investigator: Froud, R

Co-Investigators: Seers, K. Burton, K, Ellard, D., Haywood, K, Swan, Pincus, Underwood, Atkinson, Barillec, Patel, Taylor, Smith.

Funding: Arthritis UK, £299,220. Start date 1st January 2017. Duration 24 months. Extended to April 2019.


4) Title: Optimising acute care for people with dementia. A mixed methods study. (DEMCARE).

Principal Investigator: Crawford M (Imperial College, London).

Co-Investigators: Staniszewska, Seers, Crome(UCL), Quirk (RCPsy) Wallace (RCPsy) Burns (Manchester).

Funding: NIHR HS&DR. £293,805. 1st July 2016-30th June 2018

Completed Studies
1) Title: Caring for people with dementia – experiences of carers.

Principal Investigator: Seers, Kate

Co-Investigators: Tierney S, Tutton L.

Funding: ESRC Impact Acceleration Account £6,906. 2017/8

Publication: Submitted, under review.

2) Title: Meta-ethnography of healthcare professionals' experiences of treating adults with chronic musculosketal pain to improve the experience and quality of healthcare

Principal Investigator: Fran Toye (Nuffield Orthopaedic Centre (NOC), Oxford Hospitals NHS Trust

Co-investigators:: Kate Seers University of Warwick, Karen Barker (NOC).

Funder: NIHR HS&DR Research Programme

Start date: 1 Nov 2015 for 18 months

Description: This qualitative systematic review aims to increase understanding of what it is like for health care professional to work with people who have chronic pain. This will complement our completed meta ethnography what it is like to have chronic pain. It will bringing together published qualitative research which explores health care professionals’ experiences of working with people who have chronic non-malignant pain. It will do this using the methods of meta-ethnography, which is an interpretative process which aims to develop new conceptual understandings.


Toye F Seers K Barker K (2018) A meta-ethnography of healthcare professionals’ experience of treating adults with chronic musculoskeletal pain to improve the experience and quality of healthcare. NIHR Health Services and Delivery Research. 6(17) APRIL 2018 ISSN 2050-4349 DOI 10.3310/hsdr06170

Toye, F, Seers K Barker K (2017) Meta-ethnography to understand healthcare professionals' experience of treating adults with chronic non-malignant pain. BMJ Open 7:e018411. doi: 10.1136/bmjopen-2017-018411. Published 21/12/17

Video: This video summarises the findings from this study in an easily accessible way.

Further related publications:

Toye F Jenkins S Seers K Barker K. (2015) Exploring the value of qualitative research films in clinical education. BMC Medical Education. 15:214 DOI: 10.1186/s12909-015-0491-2

Toye F Seers K Hannink E Barker K (2017) A mega-ethnography of eleven systematic reviews exploring the experience of living with chronic non-malignant pain. BMC Medical Research Methodology. 17:116 https:/

3) Title: A meta-ethnography of patients’ experience of chronic non-malignant musculoskeletal pain

Start Date: November 2010. End date: October 2012

Funder: NIHR Health Services Research Board. £167,000

PI: Francine Toye (Nuffield Orthopaedic Centre)

Co-investigators: Seers, Carr (University of Bournemouth) Allcock (University of Nottingham, Briggs (University of Leeds) Barker (NOC).

Description: This qualitative systematic review aims to increase understanding of what it is like to have chronic pain, using existing research to improve knowledge and inform best practice. It has brought together 77 published qualitative research papers which explore patients’ experiences of chronic non-malignant pain. It did this using meta-ethnography, which is an interpretative process which develops new conceptual understandings.

Completed on time on 31st October 2012.

Video: Film of findings on U-tube 


Toye F, Seers K, Allcock N, Briggs M, Carr E, Andrews J, Barker, K (2013) A meta-ethnography of patients’ experience of chronic non-malignant musculoskeletal pain. Health Serv Deliv Res 2013:1(12). (Published 29th November 2013)

Toye F Seers K Allcock N Briggs M, Carr E, Andrews J, Barker K (2013) Patients' experiences of chronic non-malignant musculoskeletal pain: a qualitative systematic review. Br J Gen Pract. 63(617):e829-41. doi: 10.3399/bjgp13X675412.

Toye F, Seers K, Allcock N, Briggs MI, Carr EC, Barker, K. A synthesis of qualitative research exploring the barriers to staying in work with chronic musculoskeletal pain. Disability and Rehabilitation. DOI:10.3109/09638288.2015.1049377. Published online: 28 May 2015

Further related publications:

Seers K & Toye F (2011) What is quality in qualitative research (editorial). Evidence Based Nursing.15(1) doi: 10.1136/EBN.2011.100268.

Seers, K (2014) Qualitative systematic reviews: their relevance to our understanding of research relevant to pain. British Journal of Pain. DOI: 10.1177/2049463714549777

Toye, F., Seers, K., Barker, K. (2014) A meta-ethnography of patients’ experiences of chronic pelvic pain: struggling to construct chronic pelvic pain as ‘real’ Journal of Advanced Nursing. Published online 1st August 2014. Early View DOI: 10.1111/jan.12485

Toye, F, Seers K, Allcock, N, Briggs,M, Carr, E and Barker K. (2014) Meta-ethnography 25 years on: challenges and insights for synthesising a large number of qualitative studies BMC Medical Research Methodology 2014, 14:80 doi:10.1186/1471-2288-14-80 Published: 21 June 2014

Toye, FMA., Seers, K., Allcock, N., Briggs, M., Carr, E., Andrews, J., Barker, K. (2013) ‘Trying to pin down jelly' - exploring intuitive processes in quality assessment for meta-ethnography. BMC Medical Research Methodology 13:46. doi:10.1186/1471-2288-13-46

Toye F Seers K, Tierney, S & Barker K. (2017) A qualitative evidence synthesis to explore healthcare professionals’ experience of prescribing opioids to adults with chronic non-cancer pain. BMC Family Medicine. 18:94. Published online 25/11/17 doi: 10.1186/s12875-017-0663-8


4) FIRE Study (Facilitating Implementation of Research Evidence)

Funder: European Commission.

Start date: January 2009 End date: June 2013.

PI: Kate Seers

Collaborating Institutions on bid: Karolinksa Institute, Sweden; University of Alberta, Canada; University of Bangor; University of Ulster; Fontys University, Netherlands; Manchester Business School, University College Cork.

Description: This a pragmatic randomised controlled trial, with embedded process and economic evaluation, taking place in four European countries. It aims to increase understanding about the role of different types of facilitation in implementing research evidence into practice. It is looking specifically at using continence recommendations in long term settings. Its objectives are to: 1) Extend current knowledge of facilitation as a process for translating research evidence into practice; 2) Evaluate the feasibility, effectiveness and cost-effectiveness of two different models of facilitation in promoting the uptake of research evidence on continence management; 3) Assess the impact of contextual factors on the processes and outcomes of implementation; 4) Implement a pro-active knowledge transfer and dissemination strategy to diffuse study findings to a wide policy and practice community.

Controlled Trials ISRCTN11598502. 


Seers K, Rycroft-Malone J, Cox K, Crichton N, Edwards RT, Eldh AC, Estabrooks CA, Harvey G, Jones, C, Kitson A, McCormack B, McMullan C, Mockford C, Hawkes C, Niessen T, Slater P, Titchen A, van der Zijpp T, Wallin L. Facilitating Implementation of Research Evidence (FIRE): an international cluster randomised controlled trial to evaluate two models of facilitation informed by the Promoting Action on Research Implementation in Health Services (PARIHS) framework. Implementation Science 13(1):137 doi: 10.1186/s13012-018-0831-9.

Rycroft-Malone J, Seers K, Eldh AC, Cox K, Crichton N, Harvey G, Hawkes C, Kitson A, McCormack B, McMullan C, Mockford C, Niessen, T, Slater P, Titchen, A, van der Zijpp, T, Wallin L. A realist process evaluation within the Facilitating Implementation of Research Evidence (FIRE) cluster randomised controlled international trial: an exemplar. Implementation Science. 13(1):138 doi: 10.1186/s13012-018-0811-0.

Kitson AL, Rycroft-Malone J Harvey G McCormack B Seers K Titchen A (2008) Evaluating the successful implementation of evidence into practice using the PARiHS framework: theoretical and practical challenges. Implementation Science 7 3:1doi: 10.1186/1748-5908-3-1

Seers, K., Cox, K., Crichton, NJ., Tudor-Edwards, R., Eldh, A., Estabrooks, CA., Harvey, G., re Hawkes, C., Kitson, A., Linck, P., McCarthy, G., McCormack, B., Mockford, C., Rycroft-Malone, J., Titchen, A., & Wallin, L., (2012) FIRE (Facilitating Implementation of Research Evidence): a study protocol. Implementation Science 7: 25 doi:10.1186/1748-5908-7-25

Van der Zijpp TJ, Niessen T, Eldh A, Hawkes C, McMullan C, Mockford C, Wallin L, McCormack B, Rycroft-Malone J & Seers K. (2016) A bridge over turbulent waters - illustrating the interaction between managerial leaders and facilitators when implementing research evidence. Worldviews on Evidence-Based Nursing. 13(1):25-31. doi: 10.1111/wvn.12138

Eldh AC, vanderZijpp, T., Mcmullan C, McCormack, B. Seers K Rycroft-Malone J. (2016) ‘I have the world’s best job’ – staff experience of the advantages of caring for older people. Scandinavian Journal of Caring Sciences. 30(2): 365-373 DOI: 10.1111/scs.12256

Tue 11 Sep 2018, 14:33