Biopharmaceuticals include a broad range of bio-active molecules, from small molecules such as the base for antimalarial treatments artemisinin, to large molecules, such as proteins. Traditional medicinal chemistry benefited enormously from discovery of bio-active molecules in Nature, with over 50% of medicinally active small molecules reportedly originating from bio-resources. We continue to learn from Nature continuously seeking new bio-active molecules and developing understanding of action of molecules in human body. We also learn from the wealth of experience of human race of using natural products to learn about synergistic interactions of multi-component drugs with human body and to develop safe and effective new treatments for a variety of diseases.