Our brains contain a number of metals including copper, iron, and zinc — all of which have different roles in helping the brain function. Changes in the levels and the chemical form of these metals are tied to neurological disease. The brains of Alzheimer’s patients, for example, have altered distributions and chemical states of iron.
In an effort to better understand how metals are organised in the brains of Alzheimer’s patients, Professor Joanna CollingwoodLink opens in a new window, School of Engineering, is collaborating with colleagues at University of Toronto, University of Texas at San Antonio, and University of Florida, to delve deeper into the mechanisms that are causing changes in the iron chemistry of diseased brain tissue. Through their findings, they hope not only to advance our understanding of metals in the brain, but also to inform future treatments of diseases.
Collingwood says, “According to the Alzheimer’s Association, the disease accounts for 60 to 80 percent of dementia cases, and currently has no known cure. At this time, when the community is desperately trying to treat people and ideally protect them from developing the disease, anything that can offer a way of managing factors that make cells more vulnerable would be a great step forward.”