Job Title
Director of Warwick Clinical Trials Unit
Department
WMS - Warwick Clinical Trials Unit
Phone
02476 575130
Email
Research Interests
Professor Stallard's primary research interests are in the statistical design and analysis of clinical trials. In particular, he has worked on optimal trial design and on methodology for clinical trials with interim analyses and adaptations such as treatment or subgroup selection. His current work includes the development of innovative design methods for clinical trials in small populations and in emerging disease epidemics and methods for decision-making in clinical trials that have been interrupted.
Biography
Nigel Stallard is Professor of Medical Statistics and Director of Warwick Clinical Trials Unit. He has a BA in Mathematics from Cambridge University and an MSc in Biometry and a PhD in Applied Statsitics from the University of Reading. Prior to joining Warwick Medical School at Professor of Medical Statistics in 2005 he held research positions at the Royal Air Force Institute of Aviation Medicine in Farnborough and the Pharmaceutical Statistics Research Unit at the University of Reading. He has held major research grants from the National Institute of Health and Social Care Research, the Medical Research Council and the European Union and has published around 200 research articles in statistical and medical journals. He is currently an Editor in Chief of the journal Statistics in Medicine.
- Freeman, Karoline, Mansbridge, Alice, Stobart, H., Clements, K., Wallis, M. G., Pinder, S. E., Kearins, O., Shaaban, A. M., Kirwan, C. C., Wilkinson, L. S., Webb, S., O?Sullivan, E., Jenkins, J., Wright, S., Taylor, K., Bailey, C., Holcombe, C., Wyld, L., Edwards, K., Jenkinson, David J. et al (Select to open full list), 2024. Evidence-informed recommendations on managing breast screening atypia : perspectives from an expert panel consensus meeting reviewing results from the sloane atypia project. British Journal of Radiology, 97 (1154), pp. 324-330
- Freeman, Karoline, Jenkinson, David J., Clements, K., Wallis, M. G., Pinder, S. E., Provenzano, E., Stobart, H., Stallard, Nigel, Kearins, O., Sharma, N., Shaaban, A., Kirwan, C. C., Hilton, B., Thompson, A. M., Taylor-Phillips, Sian, 2024. Atypia detected during breast screening and subsequent development of cancer : observational analysis of the Sloane atypia prospective cohort in England. BMJ, 384
- Parsons, Nick R., Basu, Joydeep, Stallard, Nigel, 2024. Group sequential designs for pragmatic clinical trials with early outcomes : methods and guidance for planning and implementation. BMC Medical Research Methodology, 24 (1)
- Duputel, Benjamin, Stallard, Nigel, Montestruc, François, Zohar, Sarah, Ursino, Moreno, 2023. Using dichotomized survival data to construct a prior distribution for a Bayesian seamless Phase II/III clinical trial. Statistical Methods in Medical Research, 32 (5), pp. 963-977
- Stallard, Nigel, 2023. Rejoinder to discussion on ?Adaptive enrichment designs with a continuous biomarker?. Biometrics, 79 (1), pp. 36-38
- Metcalfe, Andrew J., Arnold, Susanne, Parsons, Helen, Parsons, Nicholas R., Bhabra, Gev, Brown, Jaclyn, Bush, Howard, Diokno, Michael, Elliott, Mark T., Fox, Josephine, Gates, Simon, Gemperle Mannion, Elke, Haque, Aminul, Hutchinson, Charles E., Kearney, Rebecca S., Khan, Iftekhar, Lawrence, Tom, Mason, James, Rahman, Usama, Stallard, Nigel et al (Select to open full list), 2023. Subacromial spacer for Tears Affecting Rotator cuff Tendons : a Randomised, Efficient, Adaptive Clinical Trial in Surgery (START:REACTS). Efficacy and Mechanism Evaluation, 10 (3)
- Metcalfe, Andrew J., Arnold, Susanne, Parsons, Helen, Parsons, Nicholas R., Bhabra, Gev, Brown, Jaclyn, Bush, Howard, Diokno, Michael, Elliott, Mark T., Fox, Josephine, Gates, Simon, Gemperle Mannion, Elke, Haque, Aminul, Hutchinson, Charles E., Kearney, Rebecca, Khan, Iftekhar, Lawrence, Tom, Mason, James, Rahman, Usama, Stallard, Nigel et al (Select to open full list), 2023. Subacromial spacers for adults with symptomatic, irreparable rotator cuff tears : the START:REACTS novel group sequential adaptive RCT. Efficacy and Mechanism Evaluation, 10 (3), pp. 1-146
- 'Gallacher, Daniel C., 'Stallard, Nigel, 'Kimani, Peter K., 'G?kalp, Elvan, 'Branke, Juergen, 2022. 'Development of a model to demonstrate the impact of NICE cost-effectiveness assessment on health utility for targeted medicines. Health Economics, 31 (2), pp. 417-430
- 'Schmidtke, Kelly, 'Kudrna, Laura, 'Noufaily, Angela, 'Stallard, Nigel, 'Skrybant, Magdalena, 'Russell, Samantha, 'Clarke, Aileen, 2022. 'Evaluating the relationship between moral values and vaccine hesitancy in Great Britain during the COVID-19 pandemic : a cross-sectional survey. Social Science & Medicine, 308
- 'Stallard, Nigel, 2022. 'Adaptive enrichment designs with a continuous biomarker. Biometrics
- 'Metcalfe, Andrew J., 'Parsons, Helen, 'Parsons, Nicholas R., 'Brown, Jaclyn, 'Fox, Josephine, 'Gemperle Mannion, Elke, 'Haque, Aminul, 'Hutchinson, Charles E., 'Kearney, Rebecca S., 'Khan, Iftekhar, 'Lawrence, Tom, 'Mason, James, 'Stallard, Nigel, 'Underwood, Martin, 'Drew, Stephen, 2022. 'Subacromial balloon spacer for irreparable rotator cuff tears of the shoulder (START:REACTS) : a group-sequential, double-blind, multicentre randomised controlled trial. The Lancet, 399 (10339), pp. 1954-1963
- 'Li, Vivien, 'Leurent, Baptiste, 'Barkhof, Frederik, 'Braisher, Marie, 'Cafferty, Fay H., 'Ciccarelli, Olga, 'Eshaghi, Arman, 'Gray, Emma, 'Nicholas, Jennifer M., 'Parmar, Mahesh K. B., 'Peryer, Guy, 'Robertson, Jenny, 'Stallard, Nigel, 'Wason, James, 'Chataway, Jeremy, 2022. 'Designing multi-arm multistage adaptive trials for neuroprotection in progressive multiple slerosis. Neurology
- 'Dane, Aaron, 'Rex, John H., 'Newell, Paul, 'Stallard, Nigel, 2022. 'The value of the information that can be generated : optimizing study design to enable the study of treatments addressing an unmet need for rare pathogens. Open Forum Infectious Diseases, 9 (7)
- 'Zhan, Stella Jinran, 'Kunz, Cornelia Ursula, 'Stallard, Nigel, 2022. 'Should the two?trial paradigm still be the gold standard in drug assessment?. Pharmaceutical Statistics
- 'Parsons, Nick R., 'Stallard, Nigel, 'Parsons, Helen, 'Haque, Aminul, 'Underwood, Martin, 'Mason, James, 'Khan, Iftekhar, 'Costa, Matthew L., 'Griffin, Damian R., 'Griffin, James, 'Beard, David J., 'Cook, Jonathan A., 'Davies, Loretta, 'Hudson, Jemma, 'Metcalfe, Andrew, 2022. 'Group sequential designs in pragmatic trials : feasibility and assessment of utility using data from a number of recent surgical RCTs. BMC Medical Research Methodology, 22 (1)
- Khan, Josephine N., Kimani, Peter K., Glimm, Ekkehard, Stallard, Nigel, 2022. Adjusting for treatment selection in phase II/III clinical trials with time to event data. Statistics in Medicine
- Gallacher, Daniel C., Kimani, Peter K., Stallard, Nigel, 2022. Biased survival predictions when appraising health technologies in heterogeneous populations. PharmacoEconomics - Open, pp. 109-120
- Jenkinson, David J., Freeman, Karoline, Clements, Karen, Hilton, Bridget, Dulson-Cox, Joanne, Kearins, Olive, Stallard, Nigel, Wallis, Matthew G., Sharma, Nisha, Kirwan, Cliona, Pinder, Sarah, Provenzano, Elena, Shaaban, Abeer M., Stobart, Hilary, McDonnell, Samantha J., Thompson, Alastair M., Taylor-Phillips, Sian, 2022. Breast screening atypia and subsequent development of cancer : protocol for an observational analysis of the Sloane database in England (Sloane atypia cohort study). BMJ Open, 12 (1)
- Wong, Charis, Dakin, Rachel S., Williamson, Jill, Newton, Judith, Steven, Michelle, Colville, Shuna, Stavrou, Maria, Gregory, Jenna M., Elliott, Elizabeth, Mehta, Arpan R., Chataway, Jeremy, Swingler, Robert J., Parker, Richard Anthony, Weir, Christopher J., Stallard, Nigel, Parmar, Mahesh K. B., Macleod, Malcolm R., Pal, Suvankar, Chandran, Siddharthan, 2022. Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART) : a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease. BMJ Open, 12 (7)
- 'Wong, Charis, 'Stavrou, Maria, 'Elliott, Elizabeth, 'Gregory, Jenna M., 'Leigh, Nigel, 'Pinto, Ashwin A., 'Williams, Timothy L., 'Chataway, Jeremy, 'Swingler, Robert, 'Parmar, Mahesh K. B., 'Stallard, Nigel, 'Weir, Christopher J., 'Parker, Richard A., 'Chaouch, Amina, 'Hamdalla, Hisham, 'Ealing, John, 'Gorrie, George, 'Morrison, Ian, 'Duncan, Callum, 'Connelly, Peter et al (Select to open full list), 2021. 'Clinical trials in amyotrophic lateral sclerosis : a systematic review and perspective. Brain Communications, 3 (4)
- Gallacher, Daniel C., Stallard, Nigel, Kimani, Peter K., 2021. Extrapolating parametric survival models in health technology assessment : a simulation study. Medical Decision Making, 41 (1), pp. 37-50
- Ursino, M., Stallard, Nigel, 2021. Bayesian approaches for confirmatory trials in rare diseases : opportunities and challenges. International Journal of Environmental Research and Public Health, 18 (3)
- Lee, Kim May, Brown, Louise C., Jaki, Thomas, Stallard, Nigel, Wason, James, 2021. Statistical consideration when adding new arms to ongoing clinical trials : the potentials and the caveats. Trials, 22 (1)
- Hee, Siew Wan, Mistry, Dipesh, Friede, Tim, Lamb, Sarah E., Stallard, Nigel, Underwood, Martin, Patel, Shilpa, 2021. Identification of subgroup effect with an individual participant data meta-analysis of randomised controlled trials of three different types of therapist-delivered care in low back pain. BMC Musculoskeletal Disorders, 22 (1)
- Gallacher, Daniel, Kimani, Peter, Stallard, Nigel, 2021. Extrapolating parametric survival models in Health Technology Assessment using model averaging : a simulation study. Medical Decision Making, 41 (4), pp. 476-484
- Saravanan, Ponnusamy, Sukumar, Nithya, Adaikalakoteswari, Antonysunil, Goljan, Ilona, Venkataraman, Hema, Gopinath, Amitha, Bagias, Christos, Yajnik, Chittaranjan S., Stallard, Nigel, Ghebremichael-Weldeselassie, Yonas, Fall, Caroline, 2021. Association of maternal vitamin B12 and folate levels in early pregnancy with gestational diabetes : a prospective UK cohort study (PRiDE study). Diabetologia, 64, pp. 2170-2182
- Chataway, Jeremy, De Angelis, Floriana, Connick, Peter, Parker, Richard A, Plantone, Domenico, Doshi, Anisha, John, Nevin, Stutters, Jonathan, MacManus, David, Prados Carrasco, Ferran, Barkhof, Frederik, Ourselin, Sebastien, Braisher, Marie, Ross, Moira, Cranswick, Gina, Pavitt, Sue H, Giovannoni, Gavin, Gandini Wheeler-Kingshott, Claudia Angela, Hawkins, Clive, Sharrack, Basil et al (Select to open full list), 2020. Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART) : a phase 2b, multiarm, double-blind, randomised placebo-controlled trial. The Lancet Neurology, 19 (3), pp. 214-225
- Stallard, Nigel, Hampson, Lisa, Benda, Norbert, Brannath, Werner, Burnett, Thomas, Friede, Tim, Kimani, Peter K., Koenig, Franz, Krisam, Johannes, Mozgunov, Pavel, Posch, Martin, Wason, James, Wassmer, Gernot, Whitehead, John, Williamson, S. Faye, Zohar, Sarah, Jaki, Thomas, 2020. Efficient adaptive designs for clinical trials of interventions for COVID-19. Statistics in Biopharmaceutical Research, 12 (4), pp. 483-497
- Kunz, Cornelia Ursula, Jörgens, Silke, Bretz, Frank, Stallard, Nigel, Van Lancker, Kelly, Xi, Dong, Zohar, Sarah, Gerlinger, Christoph, Friede, Tim, 2020. Clinical trials impacted by the COVID-19 pandemic : adaptive designs to the rescue?. Statistics in Biopharmaceutical Research, 12 (4), pp. 461-477
- Barker, K. L., Newman, M., Stallard, Nigel, Leal, J., Lowe, C. M., Javaid, M. K., Noufaily, Angela, Hughes, T., Smith, D., Gandhi, V., Cooper, C., Lamb, S. E., 2020. Physiotherapy rehabilitation for osteoporotic vertebral fracture?a randomised controlled trial and economic evaluation (PROVE trial). Osteoporosis International, 31, pp. 277-289
- Kimani, Peter K., Todd, Susan, Renfro, Lindsay A., Glimm, Ekkehard, Khan, Josephine N., Kairalla, John A., Stallard, Nigel, 2020. Point and interval estimation in two-stage adaptive designs with time to event data and biomarker-driven subpopulation selection. Statistics in Medicine, 39 (19), pp. 2568-2586
- Ryan, Elizabeth G., Stallard, Nigel, Lall, Ranjit, Ji, Chen, Perkins, Gavin D., Gates, Simon, 2020. Bayesian group sequential designs for phase III emergency medicine trials : a case study using the PARAMEDIC2 trial. Trials, 21 (1)
- Stallard, Nigel, Todd, Susan, Ryan, Elizabeth G., Gates, Simon, 2020. Comparison of Bayesian and frequentist group-sequential clinical trial designs. BMC Medical Research Methodology, 20 (1)
- De Angelis, Floriana, Connick, Peter, Parker, Richard A., Plantone, Domenico, Doshi, Anisha, John, Nevin, Stutters, Jonathan, MacManus, David, Prados, Ferran, Marshall, Ian, Solanky, Bhavana, Samson, Rebecca S., Barkhof, Frederik, Ourselin, Sebastien, Braisher, Marie, Ross, Moira, Cranswick, Gina, Pavitt, Sue H., Gnanapavan, Sharmilee, Giovannoni, Gavin et al (Select to open full list), 2020. Amiloride, fluoxetine or riluzole to reduce brain volume loss in secondary progressive multiple sclerosis : the MS-SMART four-arm RCT. Efficacy and Mechanism Evaluation, 7 (3), pp. 1-72
- Metcalfe, Andrew J., Gemperle Mannion, Elke, Parsons, Helen, Brown, Jaclyn, Parsons, Nicholas R., Fox, Josephine, Kearney, Rebecca S., Lawrence, Thomas, Bush, Howard, McGowan, Kerri, Khan, Iftekhar, Mason, James, Hutchinson, Charles E., Gates, Simon, Stallard, Nigel, Underwood, Martin, Drew, Steve, 2020. Protocol for a randomised controlled trial of subacromial spacers for tears affecting rotator cuff tendons : a randomised, efficient, adaptive clinical trial in surgery (START:REACTS). BMJ Open, 10
- Friede, Tim, Stallard, Nigel, Parsons, Nicholas R., 2020. Adaptive seamless clinical trials using early outcomes for treatment or subgroup selection : methods, simulation model and their implementation in R. Biometrical Journal, 62 (5)
- Perkins, Gavin D., Couper, Keith, Connolly, Bronwen, Baillie, J. Kenneth, Bradley, Judy M., Dark, Paul, De Soyza, Anthony, Gorman, Ellen, Gray, Alasdair, Hamilton, Louisa, Hart, Nicholas, Ji, Chen, Lall, Ranjit, McGowan, Nicola, Regan, Scott, Simonds, Anita K., Skilton, Emma, Stallard, Nigel, Stimpson, Emily, Yeung, Joyce et al (Select to open full list), 2020. RECOVERY- Respiratory Support : respiratory strategies for patients with suspected or proven COVID-19 respiratory failure; continuous positive airway pressure, high-flow nasal oxygen, and standard care : a structured summary of a study protocol for a randomised controlled trial. Trials, 21 (1)
- Ryan, Elizabeth G., Bruce, Julie, Metcalfe, Andrew J., Stallard, Nigel, Lamb, Sarah E., Viele, Kert, Young, Duncan, Gates, Simon, 2019. Using Bayesian adaptive designs to improve phase III trials : a respiratory care example. BMC Medical Research Methodology, 19
- Parsons, Nicholas R., Stallard, Nigel, Parsons, Helen, Wells, Philip, Underwood, Martin, Mason, James, Metcalfe, Andrew J., 2019. An adaptive two-arm clinical trial using early endpoints to inform decision making : design for a study of sub-acromial spacers for repair of rotator cuff tendon tears. Trials, 20
- Ursino, Moreno, Yuan, Ying, Alberti, Corinne, Comets, Emmanuelle, Favrais, Geraldine, Friede, Tim, Lentz, Frederike, Stallard, Nigel, Zohar, Sarah, 2019. A dose finding design for seizure reduction in neonates. Journal of the Royal Statistical Society: Series C (Applied Statistics), 68 (2), pp. 427-444
- Cook, Jonathan A., Julious, Steven A., Sones, William, Hampson, Lisa V., Hewitt, Catherine, Berlin, Jesse A., Ashby, Deborah, Emsley, Richard, Fergusson, Dean A., Walters, Stephen J., Wilson, Edward C. F., MacLennan, Graeme, Stallard, Nigel, Rothwell, Joanne C., Bland, Martin, Brown, Louise, Ramsay, Craig R., Cook, Andrew, Armstrong, David, Altman, Douglas et al (Select to open full list), 2019. Practical help for specifying the target difference in sample size calculations for RCTs : the DELTA2 five-stage study, including a workshop. Health Technology Assessment, 23 (60), pp. 1-88
- Choko, Augustine T., Corbett, Elizabeth L., Stallard, Nigel, Maheswaran, Hendramoorthy, Lepine, Aurelia, Johnson, Cheryl C., Sakala, Doreen, Kalua, Thokozani, Kumwenda, Moses, Hayes, Richard, Fielding, Katherine, 2019. HIV self-testing alone or with additional interventions, including financial incentives, and linkage to care or prevention among male partners of antenatal care clinic attendees in Malawi : an adaptive multi-arm, multi-stage cluster randomised trial. PLoS Medicine, 16 (1)
- Ondra, Thomas, Jobjörnsson, Sebastian, Beckman, Robert A., Burman, Carl-Fredrik, König, Franz, Stallard, Nigel, Posch, Martin, 2019. Optimized adaptive enrichment designs. Statistical Methods in Medical Research, 28 (7), pp. 2096-2111
- Youssef, Haney, Collantes, Enrique, Hunter, James, Stinson, Julie, Smith, Steve, Stallard, Nigel, Been, Martin, Wong, Ling, 2019. Preoperative and postoperative N-terminal pro B-type natriuretic peptide levels predict cardiac morbidity and mortality in patients undergoing colorectal cancer resection. Journal Of Colon And Rectal Cancer, 1 (3), pp. 1-9
- Barker, Karen L., Newman, Meredith, Stallard, Nigel, Leal, Jose, Minns Lowe, Catherine, Javaid, Muhammad K., Noufaily, Angela, Adhikari, Anish, Hughes, Tamsin, Smith, David J., Gandhi, Varsha, Cooper, Cyrus, Lamb, Sallie E., 2019. Exercise or manual physiotherapy compared with a single session of physiotherapy for osteoporotic vertebral fracture : three-arm PROVE RCT. Health Technology Assessment, 23 (44), pp. 1-318
- Lee, Kim May, Wason, James, Stallard, Nigel, 2019. To add or not to add a new treatment arm to a multiarm study : a decision-theoretic framework. Statistics in Medicine
- Stallard, Nigel, Todd, S, Parashar, D, Kimani, P K, Renfro, L A, 2019. On the need to adjust for multiplicity in confirmatory clinical trials with master protocols. Annals of Oncology, 30 (4), pp. 506-509
- Hee, Siew Wan, Parsons, Nicholas R., Stallard, Nigel, 2018. Decision-theoretic designs for a series of trials with correlated treatment effects using the Sarmanov multivariate beta-binomial distribution. Biometrical Journal, 60 (2), pp. 232-245
- Friede, Tim, Posch, Martin, Zohar, Sarah, Alberti, Corinne, Benda, Norbert, Comets, Emmanuelle, Day, Simon, Dmitrienko, Alex, Graf, Alexandra, Günhan, Burak Kürsad, Hee, Siew Wan, Lentz, Frederike, Madan, Jason, Miller, Frank, Ondra, Thomas, Pearce, Michael, Röver, Christian, Toumazi, Artemis, Unkel, Steffen, Ursino, Moreno et al (Select to open full list), 2018. Recent advances in methodology for clinical trials in small populations : the InSPiRe project. Orphanet Journal of Rare Diseases, 13 (1)
- Sewell, Fiona, Ragan, Ian, Indans, Ian, Marczylo, Tim, Stallard, Nigel, Griffiths, David, Holmes, Thomas, Smith, Paul, Horgan, Graham, 2018. An evaluation of the fixed concentration procedure for assessment of acute inhalation toxicity. Regulatory Toxicology and Pharmacology, 94, pp. 22-32
- Jepson, Marcus, Elliott, Daisy, Conefrey, Carmel, Wade, Julia, Rooshenas, Leila, Wilson, Caroline, Beard, David, Blazeby, Jane M., Birtle, Alison, Halliday, Alison, Stein, Rob, Donovan, Jenny L., Beard, David, Carr, Andrew, Cook, Jonathan, Cooper, Cushla, Dean, Benjamin, Donovan, Jenny L., Gray, Alastair, Gwilym, Stephen et al (Select to open full list), 2018. An observational study showed that explaining randomization using gambling-related metaphors and computer-agency descriptions impeded randomized clinical trial recruitment. Journal of Clinical Epidemiology, 99, pp. 75-83
- Day, Simon, Jonker, Anneliene Hechtelt, Lau, Lilian Pek Lian, Hilgers, Ralf-Dieter, Irony, Ilan, Larsson, Kristina, Roes, Kit C. B., Stallard, Nigel, 2018. Recommendations for the design of small population clinical trials. Orphanet Journal of Rare Diseases, 13 (1)
- Cook, Jonathan A, Julious, Steven A, Sones, William, Hampson, Lisa V, Hewitt, Catherine, Berlin, Jesse A, Ashby, Deborah, Emsley, Richard, Fergusson, Dean A, Walters, Stephen J, Wilson, Edward C F, MacLennan, Graeme, Stallard, Nigel, Rothwell, Joanne C, Bland, Martin, Brown, Louise, Ramsay, Craig R, Cook, Andrew, Armstrong, David, Altman, Doug et al (Select to open full list), 2018. DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial. BMJ Open, 363
- Cook, Jonathan A., Julious, Steven A., Sones, William, Hampson, Lisa V., Hewitt, Catherine, Berlin, Jesse A., Ashby, Deborah, Emsley, Richard, Fergusson, Dean A., Walters, Stephen J., Wilson, Edward C. F., Maclennan, Graeme, Stallard, Nigel, Rothwell, Joanne C., Bland, Martin, Brown, Louise, Ramsay, Craig R., Cook, Andrew, Armstrong, David, Altman, Doug et al (Select to open full list), 2018. DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial. Trials, 19 (1)
- Miller, Frank, Zohar, Sarah, Stallard, Nigel, Madan, Jason, Posch, Martin, Hee, Siew Wan, Pearce , Michael, Vågerö, Mårten, Day, Simon, 2018. Approaches to sample size calculation for clinical trials in rare diseases. Pharmaceutical Statistics, 17 (3), pp. 214-230
- Pearce, Michael, Hee, Siew Wan, Madan, Jason, Posch, Martin, Day, Simon, Miller, Frank, Zohar, Sarah, Stallard, Nigel, 2018. Value of information methods to design a clinical trial in a small population to optimise a health economic utility function. BMC Medical Research Methodology, 18 (1)
- Kunz, Cornelia Ursula, Jaki, Thomas, Stallard, Nigel, 2018. An alternative method to analyse the biomarker-strategy design. Statistics in Medicine, 37 (30), pp. 4636-4651
- Stallard, Nigel, Kimani, Peter K., 2018. Uniformly minimum variance conditionally unbiased estimation in multi-arm multi-stage clinical trials. Biometrika, 105 (2), pp. 495-501
- Toumazi, A., Comets, E., Alberti, C., Friede, T., Lentz, F., Stallard, Nigel, Zohar, S., Ursino, M., 2018. dfpk : An R-package for Bayesian dose-finding designs using Pharmacokinetics (PK) for phase I clinical trials. Computer Methods and Programs in Biomedicine, 157, pp. 163-177
- Marshall, Ian, Thrippleton, Michael J., Bastin, Mark E., Mollison, Daisy, Dickie, David A., Chappell, Francesca M., Semple , Scott I. K., Cooper, Annette, Pavitt, Sue, Giovannoni, Gavin, Wheeler-Kingshott, Claudia A. M. Gandini, Solanky, Bhavana S., Weir, Christopher J., Stallard, Nigel, Hawkins, Clive, Sharrack, Basil, Chataway, Jeremy, Connick, Peter, Chandran, Siddharthan, 2018. Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis : a magnetic resonance spectroscopic imaging study. Journal of Neurology, 265 (8), pp. 1795-1802
- Kimani, Peter K., Todd, Susan, Renfro, Lindsay A., Stallard, Nigel, 2018. Point estimation following two-stage adaptive threshold enrichment clinical trials. Statistics in Medicine, 37 (22), pp. 3179-3196
- Perkins, Gavin D., Ji, Chen, Deakin, Charles D., Quinn, Tom, Nolan, Jerry P., Scomparin, Charlotte, Regan, Scott, Long, John, Slowther, Anne, Pocock, Helen, Black, John J. M., Moore, Fionna, Fothergill, Rachael, Rees, Nigel, O?Shea, Lyndsey, Docherty, Mark, Gunson, Imogen, Han, Kyee, Charlton, Karl, Finn, Judith et al (Select to open full list), 2018. A randomized trial of epinephrine in out-of-hospital cardiac arrest. New England Journal Of Medicine, 379, pp. 711-721
- Cook, Jonathan A., Julious, Steven A., Sones, William, Hampson, Lisa V., Hewitt, Catherine, Berlin, Jesse A., Ashby, Deborah, Emsley, Richard, Fergusson, Dean A., Walters, Stephen J., Wilson, Edward C. F., Maclennan, Graeme, Stallard, Nigel, Rothwell, Joanne C., Bland, Martin, Brown, Louise, Ramsay, Craig R., Cook, Andrew, Armstrong, David, Altman, Doug et al (Select to open full list), 2018. DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial. British Medical Journal, 363
- Mistry, Dipesh, Stallard, Nigel, Underwood, Martin, 2018. A recursive partitioning approach for subgroup identification in individual patient data meta-analysis. Statistics in Medicine, 37 (9), pp. 1550-1561
- Wason, James M. S., Stallard, Nigel, Bowden, Jack, Jennison, Christopher, 2017. A multi-stage drop-the-losers design for multi-arm clinical trials. Statistical Methods in Medical Research, 26 (1), pp. 508-524
- Ellard, David R., Underwood, Martin, Achana, Felix A., Antrobus, James H. L., Balasubramanian, Shyam, Brown, Sally, Cairns, Melinda, Griffin, James M., Griffiths, Frances, Haywood, Kirstie L., Hutchinson, Charles E., Lall, Ranjit, Petrou, Stavros, Stallard, Nigel, Tysall, Colin, Walsh, David A., Sandhu, Harbinder, 2017. Facet joint injections for people with persistent non-specific low back pain (Facet Injection Study) : a feasibility study for a randomised controlled trial. Health Technology Assessment, 21 (30), pp. 1-184
- Stallard, Nigel, Miller, Frank, Day, Simon, Hee, Siew Wan, Madan, Jason, Zohar, Sarah, Posch, Martin, 2017. Determination of the optimal sample size for a clinical trial accounting for the population size. Biometrical Journal, 59 (4), pp. 609-625
- Hee, Siew Wan, Willis, Adrian, Tudur Smith, Catrin, Day, Simon, Miller, Frank, Madan, Jason, Posch, Martin, Zohar, Sarah, Stallard, Nigel, 2017. Does the low prevalence affect the sample size of interventional clinical trials of rare diseases? An analysis of data from the aggregate analysis of clinicaltrials.gov. Orphanet Journal of Rare Diseases, 12 (44)
- Ursino, Moreno, Zohar, Sarah, Lentz, Frederike, Alberti, Corinne, Friede, Tim, Stallard, Nigel, Comets, Emmanuelle, 2017. Dose-finding methods for Phase I clinical trials using pharmacokinetics in small populations. Biometrical Journal, 59 (4), pp. 804-825
- Kunz, Cornelia, Stallard, Nigel, Parsons, Nicholas R., Todd, Susan, Friede, Tim, 2017. Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations. Biometrical Journal, 59 (2), pp. 344-357
- Robertson, Wendy, Fleming, J, Kamal, Atiya, Hamborg , T, Khan, K. A., Griffiths, Frances, Stewart-Brown, Sarah L., Stallard, Nigel, Petrou, Stavros, Simkiss, Douglas E., Harrison, Elizabeth, Kim, S. W., Thorogood, Margaret, 2017. Randomised controlled trial evaluating the effectiveness and cost-effectiveness of 'Families for Health', a family-based childhood obesity treatment intervention delivered in a community setting for ages 6 to 11 years. Health Technology Assessment, 21 (1)
- Robertson, Wendy, Fleming, Joanna, Kamal, Atiya, Hamborg, Thomas, Khan, Kamaran A., Griffiths, Frances, Stewart-Brown, Sarah L., Stallard, Nigel, Petrou, Stavros, Simkiss, Douglas E., Harrison, Elizabeth, Kim, S. W., Thorogood, Margaret, 2017. Randomised controlled trial and economic evaluation of the ?Families for Health? programme to reduce obesity in children. Archives of Disease in Childhood, 102 (5), pp. 416-426
- Hee, Siew Wan, Hamborg, Thomas, Day, Simon, Madan, Jason, Miller, F., Posch, Martin, Zohar, Sarah, Stallard, Nigel, 2016. Decision-theoretic designs for small trials and pilot studies : a review. Statistical methods in medical research, 25 (3), pp. 1022-1038
- Patel, Shilpa, Hee, Siew Wan, Mistry, Dipesh, Jordan, Jake, Brown, S., Dritsaki, Melina, Ellard, David R., Friede, Tim, Lamb, S. E., Lord, Joanne, Madan, Jason, Morris, Tom, Stallard, Nigel, Tysall, Colin, Willis, Adrian, Underwood, Martin, 2016. Identifying back pain subgroups : developing and applying approaches using individual patient data collected within clinical trials. Programme Grants for Applied Research, 4 (10)
- McAloon, Christopher, Boylan, Luke M., Hamborg, Thomas, Stallard, Nigel, Osman, Faizel, Lim, Phang B., Hayat, Sajad A., 2016. The changing face of cardiovascular disease 2000?2012 : an analysis of the world health organisation global health estimates data. International Journal of Cardiology, 224, pp. 256-264
- Ondra, Thomas, Jobjörnsson, Sebastian, Beckman, Robert A., Burman, Carl-Fredrik, König, Franz, Stallard, Nigel, Posch, Martin, 2016. Optimizing trial designs for targeted therapies. PLoS One, 11 (9)
- Price, Charlotte L, Brace-McDonnell, Samantha J., Stallard, Nigel, Bleetman, Anthony, Maconochie, I., Perkins, Gavin D., 2016. Performance characteristics of five triage tools for major incidents involving traumatic injuries to children. Injury, 47 (5), pp. 988-992
- Stein, Robert C., Dunn, Janet A., Bartlett, John M. S., Campbell, Amy, Marshall, A. (Andrea)?, Hall, Peter, Rooshenas, Leila, Morgan, Adrienne, Poole, Christopher, Pinder, Sarah E., Cameron, David A., Stallard, Nigel, Donovan, Jenny L., McCabe, Christopher, Hughes-Davies, Luke, Makris, Andreas, 2016. R : OPTIMA prelim : a randomised feasibility study of personalised care in the treatment of women with early breast cancer. Health Technology Assessment, 20 (10), pp. 1-202
- Hilgers, Ralf-Dieter, Roes, Kit, Stallard, Nigel, 2016. Directions for new developments on statistical design and analysis of small population group trials. Orphanet Journal of Rare Diseases, 11 (1)
- Ondra, Thomas, Dmitrienko, Alex, Friede, Tim, Graf, Alexandra, Miller, F. (Frank), Stallard, Nigel, Posch, Martin, 2016. Methods for identification and confirmation of targeted subgroups in clinical trials : a systematic review. Journal of Biopharmaceutical Statistics, 26 (1), pp. 99-119
- Unkel, Steffen, Röver, Christian, Stallard, Nigel, Benda, Norbert, Posch, Martin, Zohar, Sarah, Friede, Tim, 2016. Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions. Orphanet Journal of Rare Diseases, 11 (1)
- Taylor-Phillips, Sian, Wallis, Matthew G., Jenkinson, David J., Adekanmbi, Victor, Parsons, Helen, Dunn, Janet A., Stallard, Nigel, Szczepura, Ala, Gates, Simon, Kearins, Olive, Duncan, Alison, Hudson, Sue, Clarke, Aileen, 2016. Effect of using the same vs different order for second readings of screening mammograms on rates of breast cancer detection : a randomized clinical trial. JAMA: The Journal of the American Medical Association, 315 (18), pp. 1956-1965
- Perkins, Gavin D., Quinn, Tom, Deakin, Charles D., Nolan, Jerry, Lall, Ranjit, Slowther, Anne, Cooke, Matthew, Lamb, S. E. (Sallie E.), Petrou, Stavros, Achana, Felix A., Finn, Judith, Jacobs, Ian G., Carson, Andrew, Smyth, Michael A., Hann, Kyee, Byers, Sonia, Rees, Nigel, Whitfield, Richard, Moore, Fionna, Fothergill, Rachael et al (Select to open full list), 2016. Pre-hospital assessment of the role of adrenaline : measuring the effectiveness of drug administration in cardiac arrest (PARAMEDIC-2) : Trial protocol. Resuscitation, 108, pp. 75-81
- Morris, Tom, Hee, Siew Wan, Stallard, Nigel, Underwood, Martin, Patel, Shilpa, 2015. Can we convert between outcome measures of disability for chronic low back pain?. Spine, 40 (10), pp. 734-739
- Sandhu, Harbinder, Ellard, David R., Achana, Felix A., Antrobus, James H. L., Balasubramanian, Shyam, Brown, Sally, Cairns, Melinda, Griffiths, Frances, Haywood, Kirstie L., Hutchinson, Charles E., Lall, Ranjit, Petrou, Stavros, Stallard, Nigel, Tysall, Colin, Walsh, David A., Underwood, Martin, 2015. Facet-joint injections for people with persistent non-specific low back pain (FIS) : study protocol for a randomised controlled feasibility trial. Trials, 16 (1)
- Stallard, Nigel, Kunz, Cornelia, Todd, Susan, Parsons, Nicholas R., Friede, Tim, 2015. Flexible selection of a single treatment incorporating short-term endpoint information in a phase II/III clinical trial. Statistics in Medicine, 34 (23), pp. 3104-3115
- Kunz, Cornelia, Friede, Tim, Parsons, Nicholas R., Todd, Susan, Stallard, Nigel, 2015. A comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints. Journal of Biopharmaceutical Statistics, 25 (1), pp. 170-189
- Williams, Stefanie L., Michie, Susan, Dale, Jeremy, Stallard, Nigel, French, David P., 2015. The effects of a brief intervention to promote walking on Theory of Planned Behavior constructs : a cluster randomized controlled trial in general practice. Patient Education and Counseling, 98 (5), pp. 651-659
- Couper, Keith, Kimani, Peter K., Abella, Benjamin S., Chilwan, Mehboob, Cooke, Matthew, Davies, Robin P., Field, Richard A., Smith, F. Gao (Fang Gao), Quinton, Sarah, Stallard, Nigel, Woolley, Sarah, Perkins, Gavin D., 2015. The system-wide effect of real-time audiovisual feedback and postevent debriefing for in-hospital cardiac arrest. Critical Care Medicine, 43 (11), pp. 2321-2331
- Kimani, Peter K., Todd, Susan, Stallard, Nigel, 2015. Estimation after subpopulation selection in adaptive seamless trials. Statistics in Medicine, 34 (18), pp. 2581-2601
- Kimani, Peter K., Todd, Susan, Stallard, Nigel, 2014. A comparison of methods for constructing confidence intervals after phase II/III clinical trials. Biometrical Journal, 56 (1), pp. 107-128
- Stallard, Nigel, Hamborg, Thomas, Parsons, Nicholas R., Friede, Tim, 2014. Adaptive designs for confirmatory clinical trials with subgroup selection. Journal of Biopharmaceutical Statistics, 24 (1), pp. 168-187
- Kunz, Cornelia, Friede, Tim, Parsons, Nicholas R., Todd, Susan, Stallard, Nigel, 2014. Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data. Pharmaceutical Statistics, 13 (4), pp. 238-246
- Barker, Karen, MSc, Javaid, Muhammad K., Newman, Meredith, Lowe, Catherine Minns, Stallard, Nigel, Campbell, Helen, Gandhi, Varsha, Lamb, S. E. (Sallie E.), 2014. Physiotherapy rehabilitation for osteoporotic vertebral fracture (PROVE) : study protocol for a randomised controlled trial. Trials, 15 (1)
- Mistry, Dipesh, Patel, Shilpa, Hee, Siew Wan, Stallard, Nigel, Underwood, Martin, 2014. Evaluating the quality of subgroup analyses in randomized controlled trials of therapist-delivered interventions for nonspecific low back pain. Spine, 39 (7), pp. 618-629
- Couper, Keith, Kimani, Peter K., Chilwan, Mehboob, Cooke, Matthew, Davies, Robin P., Field, Richard A., Smith, F. Gao (Fang Gao), Quinton, Sarah, Stallard, Nigel, Perkins, Gavin D., 2014. The impact of real-time audiovisual feedback and post-event debriefing : the CPR quality improvement initiative. Resuscitation, 85 (1)
- Minas, Giorgos, Aston, John A. D., Stallard, Nigel, 2014. Adaptive multivariate global testing. Journal of the American Statistical Association, 109 (506)
- Magirr, Dominic, Stallard, Nigel, Jaki, Thomas, 2014. Flexible sequential designs for multi-arm clinical trials. Statistics in Medicine, 33 (19), pp. 3269-3279
- Szczepura, Ala, Manzoor, Susan, Hardy, K. (Katherine), Stallard, Nigel, Parsons, Helen, Gossain, Savita, Hawkey, P. M. (Peter M.), 2014. How do hospital professionals involved in a randomised controlled trial perceive the value of genotyping vs. PCR-ribotyping for control of hospital acquired C. difficile infections?. BMC Infectious Diseases, 14 (1)
- Mistry, Dipesh, Patel, Shilpa, Hee, Siew Wan, Stallard, Nigel, Underwood, Martin, 2014. Evaluating the quality of subgroup analyses in randomized controlled trials of therapist delivered interventions for non-specific low back pain : a systematic review. Spine, 39 (7), pp. 618-629
- Wason, J., Marshall, A. (Andrea)?, Dunn, Janet A., Stein, R. C., Stallard, Nigel, 2014. Adaptive designs for clinical trials assessing biomarker-guided treatment strategies. British Journal of Cancer, 110 (8), pp. 1950-1957
- Taylor-Phillips, Sian, Wallis, Matthew G., Parsons, Helen, Dunn, Janet A., Stallard, Nigel, Campbell, Helen, Sellars, Sarah, Szczepura, Ala, Gates, Simon, Clarke, Aileen, 2014. Changing case order to optimise patterns of performance in mammography screening (CO-OPS) : study protocol for a randomized controlled trial. Trials, 15
- Friede, Tim, Parsons, Nicholas R., Stallard, Nigel, 2013. Correction : A conditional error function approach for subgroup selection in adaptive clinical trials. Statistics in Medicine, 32 (14), pp. 2513-2514
- Simkiss, Douglas E., Stallard, Nigel, Thorogood, Margaret, 2013. A systematic literature review of the factors associated with children entering public care. Child: Care, Health and Development, 39 (5), pp. 628-642
- Robertson, Wendy, Stewart-Brown, Sarah L., Stallard, Nigel, Petrou, Stavros, Griffiths, Frances, Thorogood, Margaret, Simkiss, Douglas E., Lang, R. (Rebecca), Reddington, Kate, Poole, Francine, Rye, G. (Gloria), Khan, Kamran, Hamborg, Thomas, Kirby, J. (Joanna), 2013. Evaluation of the effectiveness and cost-effectiveness of Families for Health V2 for the treatment of childhood obesity : study protocol for a randomized controlled trial. Trials, 14 (1)
- Wason, James M. S., Jaki, Thomas, Stallard, Nigel, 2013. Planning multi-arm screening studies within the context of a drug development program. Statistics in Medicine, 32 (20), pp. 3424-3435
- Simkiss, Douglas E., Stallard, Nigel, Thorogood, Margaret, 2013. A systematic review of the risk factors associated with children entering public care. Child: Care, Health and Development, 39 (5), pp. 628-642
- Kimani, Peter K., Todd, Susan C., Stallard, Nigel, 2013. Conditionally unbiased estimation in phase II/III clinical trials with early stopping for futility. Statistics in Medicine, 32 (17), pp. 2893-2901
- Bartlett, J., Canney, P., Campbell, A. M., Cameron, D., Donovan, Jenny, Dunn, Janet A., Earl, Helena M., Francis, A., Hall, P., Harmer, V., Higgins, Helen B., Hillier, L., Hulme, C., Hughes-Davies, Luke, Makris, A., Morgan, A., McCabe, Chris, Pinder, S., Poole, Christopher J., Rea, D. et al (Select to open full list), 2013. Selecting breast cancer patients for chemotherapy : the opening of the UK OPTIMA trial. Clinical Oncology, 25 (2), pp. 109-116
- Simkiss, Douglas E., Snooks, Helen, Stallard, Nigel, Kimani, Peter K., Sewell, Bernadette, Fitzsimmons, Deborah, Anthony, Rebecca, Winstanley, Sarah, Wilson, Lynsey, Phillips, Ceri, Stewart-Brown, Sarah L., 2013. Effectiveness and cost-effectiveness of a universal parenting skills programme in deprived communities : multicentre randomised controlled trial. BMJ Open, 3 (8)
- Perkins, Gavin D., Kimani, Peter K., Bullock, Ian, Clutton-Brock, T., Davies, R. P, Gale, M., Lam, J., Lockey, A., Stallard, Nigel, 2012. Improving the efficiency of advanced life support training : a randomized, controlled trial. Annals of Internal Medicine, 157 (1), pp. 19-28
- Kimani, Peter K., Glimm, Ekkehard, Maurer, Willi, Hutton, Jane, Stallard, Nigel, 2012. Practical guidelines for adaptive seamless phase II/III clinical trials that use Bayesian methods. Statistics in Medicine, Vol.31 (No.19), pp. 2068-2085
- Armstrong, Natalie, Baines, Darrin L., Baker, Richard H., Crossman, Richard, Davies, Melanie, Hardy, Ainsley, Khunti, Kamlesh, Kumar, Sudhesh, O'Hare, J. Paul, Raymond, Neil T., Saravanan, Ponnusamy, Stallard, Nigel, Szczepura, Ala, Wilson, Andrew, 2012. A cluster randomized controlled trial of the effectiveness and cost-effectiveness of Intermediate Care Clinics for Diabetes (ICCD) : study protocol for a randomized controlled trial. Trials, Vol.13 (No.1)
- Stallard, Nigel, 2012. Optimal sample sizes for phase II clinical trials and pilot studies. Statistics in Medicine, Vol.31 (No.11-12), pp. 1031-1042
- Simkiss, Douglas E., Spencer, Nick, Stallard, Nigel, Thorogood, Margaret, 2012. Health service use in families where children enter public care : a nested case control study using the General Practice Research Database. BMC Health Services Research, Vol.12 (No.1)
- Hee, Siew Wan, Stallard, Nigel, 2012. Designing a series of decision-theoretic phase II trials in a small population. Statistics in Medicine, Vol.31 (No.30), pp. 4337-4351
- Parsons, Nicholas R., Friede, Tim, Todd, S., Marquez, Elsa Valdes, Chataway, J., Nicholas, Richard, Stallard, Nigel, 2012. An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection. Computational Statistics & Data Analysis, Vol.56 (No.5), pp. 1150-1160
- Minas, Giorgos, Rigat, Fabio, Nichols, Thomas E., Aston, John A. D., Stallard, Nigel, 2012. A hybrid procedure for detecting global treatment effects in multivariate clinical trials : theory and applications to fMRI studies. Statistics in Medicine, Vol.31 (No.3), pp. 253-268
- Hardy, K. (Katherine), Manzoor, Susan, Marriott, C., Parsons, Helen, Waddington, C., Gossain, Savita, Szczepura, Ala, Stallard, Nigel, Hawkey, P. M. (Peter M.), 2012. Utilizing rapid multiple-locus variable-number tandem-repeat analysis typing to aid control of hospital-acquired clostridium difficile infection : a multicenter study. Journal of Clinical Microbiology, Vol.50 (No.10), pp. 3244-3248
- Powell, John, Hamborg, Thomas, Stallard, Nigel, Burls, Amanda, McSorley, Jaime, Bennett, Kylie, Griffiths, Kathleen M, Christensen, Helen, 2012. Effectiveness of a web-based cognitive-behavioral tool to improve mental well-being in the general population : randomized controlled trial. Journal of Medical Internet Research, 15 (1)
- Friede, Tim, Parsons, Nicholas R., Stallard, Nigel, 2012. A conditional error function approach for subgroup selection in adaptive clinical trials. Statistics in Medicine, Vol.31 (No.30), pp. 4309-4320
- Kilner, T. M., Brace, Samantha J., Cooke, Matthew (Professor of clinical systems design), Stallard, Nigel, Bleetman, A., Perkins, Gavin D., 2011. In ?big bang' major incidents do triage tools accurately predict clinical priority? : a systematic review of the literature. Injury, Vol.42 (No.5), pp. 460-468
- Perkins, Gavin D., Davies, Robin P., Quinton, Sarah, Woolley, Sarah, Smith, F. Gao (Fang Gao), Abella, Benjamin S., Stallard, Nigel, Cooke, Matthew (Professor of clinical systems design), 2011. The effect of real-time CPR feedback and post event debriefing on patient and processes focused outcomes : a cohort study : trial protocol. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol.19 (No.1)
- Stallard, Nigel, 2011. An adaptive seamless phase II/III clinical trial design incorporating short-term endpoint information. Trials, Vol.12 (Suppl.1)
- Stallard, Nigel, 2011. Group-sequential methods for adaptive seamless phase II/III clinical trials. Journal of Biopharmaceutical Statistics, Vol.21 (No.4), pp. 787-801
- French, David, Williams, Stefanie L., Michie, Susan, Taylor, Claire, Szczepura, Ala, Stallard, Nigel, Dale, Jeremy, 2011. A cluster randomised controlled trial of the efficacy of a brief walking intervention delivered in primary care : study protocol. BMC Family Practice, Vol.12 (No.1)
- Friede, Tim, Parsons, Nicholas R., Stallard, Nigel, Todd, S. (Susan), Valdes Marquez, E., Chataway, Jeremy, Nicholas, R. (Richard), 2011. Designing a seamless phase II/III clinical trial using early outcomes for treatment selection : an application in multiple sclerosis. Statistics in Medicine, Vol.30 (No.13), pp. 1528-1540
- Stallard, Nigel, Todd, S., 2011. Seamless phase II/III designs. Statistical Methods in Medical Research, Vol.20 (No.6), pp. 623-634
- Perkins, Gavin D., Davies, Robin P., Quinton, Sarah, Woolley, Sarah, Gao, F., Abella, Benjamin S., Stallard, Nigel, Cooke, Matthew (Professor of clinical systems design), 2011. The effect of real-time CPR feedback and post event debriefing on patient and processes focused outcomes : A cohort study: trial protocol. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 19 (1)
- Chataway, J., Nicholas, R., Todd, S., Miller, D. H., Parsons, Nicholas R., Valdes-Marquez, E., Stallard, Nigel, Friede, Tim, 2011. A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis. Multiple Sclerosis Journal, Vol.17 (No.1), pp. 81-88
- Leung, Edmund, Ferjani, Ali M., Kitchen, Andrew, Griffin, Damian R., Stallard, Nigel, Wong, Ling S., 2011. Risk-adjusted scoring systems can predict surgeons' performance in colorectal surgery. Surgeon, Vol.9 (No.1), pp. 3-7
- Stallard, Nigel, Price, Charlotte L, Creton, Stuart, Indans, Ian, Guest, Robert, Griffiths, David, Edwards, Philippa, 2011. A new sighting study for the fixed concentration procedure to allow for gender differences. Human & Experimental Toxicology, Vol.30 (No.3), pp. 239-249
- Stewart-Brown, Sarah L., Anthony, Rebecca, Wilson, Lynsey, Winstanley, Sarah, Stallard, Nigel, Snooks, Helen, Simkiss, Douglas E., 2011. Should randomised controlled trials be the "gold standard" for research on preventive interventions for children?. Journal of Children's Services, Vol.6 (No.4), pp. 228-235
- Price, Charlotte L, Stallard, Nigel, Creton, Stuart, Indans, Ian, Guest, Robert, Griffiths, David, Edwards, Philippa, 2011. A statistical evaluation of the effects of gender differences in assessment of acute inhalation toxicity. Human & Experimental Toxicology, Vol.30 (No.3), pp. 217-238
- Davies, Robin P., Lam, Jenny, Bullock, Ian, Clutton-Broch, Tom, Gales, Mike, Lockey, Andrew, Kimani, Peter K., Stallard, Nigel, Perkins, Gavin D., 2011. Blended advanced life support training : a randomized controlled noninferiority trial. Circulation, Vol. 124
- Brannath, Werner, Burger, Hans Ulrich, Glimm, Ekkehard, Stallard, Nigel, Vandemeulebroecke, Marc, Wassmer, Gernot, 2010. Comments on the draft guidance on ?Adaptive design clinical trials for drugs and biologics? of the U.S. Food and Drug Administration. Journal of Biopharmaceutical Statistics, Vol.20 (No.6), pp. 1125-1131
- Simkiss, Douglas E., Snooks, Helen, Stallard, Nigel, Davies, Shan, Thomas, Marie A., Anthony, Becky, Winstanley, Sarah, Wilson, Lynsey, Stewart-Brown, Sarah L., 2010. Measuring the impact and costs of a universal group based parenting programme : protocol and implementation of a trial. BMC Public Health, Vol.10
- Stallard, Nigel, 2010. A confirmatory seamless phase II/III clinical trial design incorporating short-term endpoint information. Statistics in Medicine, Vol.29 (No.9), pp. 959-971
- Friede, Tim, Nicholas, Richard, Stallard, Nigel, Todd, Susan, Parsons, Nicholas R., Valdes-Marquez, Elsa, Chataway, J., 2010. Refinement of the clinical scenario evaluation framework for assessment of competing development strategies with an application to multiple sclerosis. Drug Information Journal, Vol.44 (No.6), pp. 713-718
- Chataway, J., Nicholas, R., Todd, S., Stallard, Nigel, Valdes-Marquez, E., Parsons, Nicholas R., Friede, Tim, 2009. FP36-WE-01 Adaptive seamless trial designs in neurology : a case study in secondary progressive multiple sclerosis. Journal of the Neurological Sciences, Vol.285 (Supp.1), pp. S113-S114
- Stallard, Nigel, Posch, Martin, Friede, Tim, Koenig, F. (Franz), Brannath, Werner, 2009. Optimal choice of the number of treatments to be included in a clinical trial. Statistics in Medicine, Vol.28 (No.9), pp. 1321-1338
- Stallard, Nigel, 2009. Simple tests for the external validation of mortality prediction scores. Statistics in Medicine, Vol.28 (No.3), pp. 377-388
- Hardy, K. (Katherine), Price, Charlotte L, Szczepura, Ala, Gossain, Savita, Davies, Ruth, Stallard, Nigel, Shabir, Sahida, McMurray, Claire, Bradbury, Andrew, Hawkey, P. M. (Peter M.), 2009. Reduction in the rate of methicillin-resistant Staphylococcus aureus acquisition in surgical wards by rapid screening for colonization : a prospective, cross-over study. Clinical Microbiology and Infection, Vol.16 (No.4), pp. 333-339
- Whitehead, John, Kelly, P. J., Zhou, Yinghui, Stallard, Nigel, Thygesen, Helene, Bowman, Clive, 2009. Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme. Pharmaceutical Statistics, Vol.8 (No.4), pp. 287-300
- Sandhu, Harbinder, Dale, Jeremy, Stallard, Nigel, Crouch, R., Glucksman, E., 2009. Emergency nurse practitioners and doctors consulting with patients in an emergency department : a comparison of communication skills and satisfaction. Emergency Medicine Journal, Vol.26 (No.6), pp. 400-404
- Leung, Edmund, Ferjani, Ali M., Stallard, Nigel, Wong, Ling S., 2009. Predicting post-operative mortality in patients undergoing colorectal surgery using P-POSSUM and CR-POSSUM scores : a prospective study. International Journal of Colorectal Disease, Vol.24 (No.12), pp. 1459-1464
- Chataway, J., Nicholas, R., Todd, S., Stallard, Nigel, Valdes-Marquez, E., Parsons, Nicholas R., Friede, Tim, 2009. Adaptive seamless trial designs in neurology : a case study in secondary progressive multiple sclerosis [Abstract]. Journal of the Neurological Sciences, Vol.285 (Suppl.1), pp. S113-S114
- Kimani, Peter K., Stallard, Nigel, Hutton, Jane, 2009. Dose selection in seamless phase II/III clinical trials based on efficacy and safety. Statistics in Medicine, Vol.28 (No.6), pp. 917-936
- Parsons, Nicholas R., Costa, Matthew L., Achten, Juul, Stallard, Nigel, 2009. Repeated measures proportional odds logistic regression analysis of ordinal score data in the statistical software package R. Computational Statistics & Data Analysis, Vol.53 (No.3), pp. 632-641
- Stallard, Nigel, Todd, S., Whitehead, John, 2008. Estimation following selection of the largest of two normal means. Journal of Statistical Planning and Inference, Vol.138 (No.6), pp. 1629-1638
- Waylen, Andrea, Stallard, Nigel, Stewart-Brown, Sarah L., 2008. Parenting and health in mid-childhood : a longitudinal study. European Journal of Public Health, Vol.18 (No.3), pp. 300-305
- Stallard, Nigel, Cockey, Louise, 2008. Two-stage designs for phase II cancer trials with ordinal responses. Contemporary Clinical Trials, Vol.29 (No.6), pp. 896-904
- Kandala, Ngianga-Bakwin, Ji, Chen, Stallard, Nigel, Stranges, Saverio, Cappuccio, Francesco, 2008. Morbidity from diarrhoea, cough and fever among youngchildren in Nigeria. Annals of Tropical Medicine & Parasitology, Vol.102 (No.5), pp. 427-445
- Goodyear, S. J., Stallard, Nigel, Gaunt, Anne, Parker, R. (Ron), Williams, N., Wong, L., 2008. Local impact of the English arm of the UK bowel cancer screening pilot study. British Journal of Surgery, Vol.95 (No.9), pp. 1172-1179
- Kelly, Patrick, Zhou, Yinghui, Whitehead, John, Stallard, Nigel, Bowman, Clive, 2008. Sequentially testing for a gene-drug interaction in a genomewide analysis. Statistics in Medicine, Vol.27 (No.11), pp. 2022-2034
- Friede, Tim, Stallard, Nigel, 2008. A comparison of methods for adaptive treatment selection. Biometrical Journal, Vol.50 (No.5 Sp. Iss. SI), pp. 767-781
- Marzanski, Marek, Jainer, Ashok Kumar, Stallard, Nigel, 2008. Naturalistic study of the efficacy of different treatment strategies in relapse prevention in bipolar affective disorders. International Medical Journal, Vol.15 (No.4), pp. 277-285
- Stallard, Nigel, Friede, Tim, 2008. A group-sequential design for clinical trials with treatment selection. Statistics in Medicine, Vol.27 (No.29), pp. 6209-6227
- Perkins, Gavin D., Davies, Robin P., Stallard, Nigel, Bullock, Ian, Stevens, Harry, Lockey, Andrew, 2007. Advanced life support cardiac arrest scenario test evaluation. Resuscitation, 75 (3), pp. 484-490
- Kandala, Ngianga-Bakwin, Ji, Chen, Stallard, Nigel, Stranges, Saverio, Cappuccio, Francesco, 2007. Spatial analysis of risk factors for childhood morbidity in Nigeria. American Journal of Tropical Medicine and Hygiene, Vol.77 (No.4), pp. 770-779
- Hardy, K. (Katherine), Szczepura, Ala, Davies, Ruth, Bradbury, Andrew, Stallard, Nigel, Gossain, Savita, Walley, Paul, Hawkey, P. M. (Peter M.), 2007. A study of the efficacy and cost-effectiveness of MRSA screening andmonitoring on surgical wards using a new, rapid molecular test(EMMS). BMC Health Services Research, Vol.7 (No.160)
- Ferjani, A. M., Griffin, Damian R., Stallard, Nigel, Wong, L. S., 2007. A newly devised scoring system for prediction of mortality in patients with colorectal cancer : a prospective study. Lancet Oncology, 8 (4), pp. 317-322
- Kelly, Patrick, Stallard, Nigel, Zhou, Yinghui, Whitehead, John, Bowman, Clive, 2006. Sequential genome-wide association studies for monitoring adverse events in the clinical evaluation of new drugs. Statistics in Medicine, Vol.25 (No.18), pp. 3081-3092
- Belsky, Jay, Bell, Brian, Bradley, Robert H., Stallard, Nigel, Stewart-Brown, Sarah L., 2006. Socioeconomic risk, parenting during the preschool years and child health age 6 years. European Journal of Public Health, Vol.17 (No.5), pp. 508-513
- Verzilli, Claudio J., Stallard, Nigel, Whittaker, John C., 2006. Bayesian graphical models for genomewide association studies. American Journal of Human Genetics, 79 (1), pp. 100-112
- Stallard, Nigel, Friede, Tim, 2011. Efficiency of adaptive designs. Pong, Annpey; Chow, Shein-Chung (eds.), Handbook of adaptive designs in pharmaceutical and clinical development, Boca Raton, CRC Press
- Stallard, Nigel, 2011. Decision theory. Everitt, Brian S.; Palmer, Christopher R. (eds.), Encyclopaedic companion to medical statistics, Chichester, West Sussex, U.K., John Wiley & Sons
- Stallard, Nigel, 2011. Sequential analysis. Everitt, Brian S.; Palmer, Christopher R. (eds.), Encyclopaedic companion to medical statistics, Chichester, West Sussex, U.K., John Wiley & Sons
- Stallard, Nigel, Todd, S., 2009. Monitoring. In Gad, Shayne Cox (ed.), Clinical trials handbook, Hoboken, N.J., Wiley, pp. 1019-1042
- Stallard, Nigel, 2008. Phase II clinical trials. In Biswas, A.; Datta, S.; Fine, J. P.; Segal, M. R. (eds.), Statistical advances in the biomedical sciences : clinical trials, epidemiology, survival analysis, and bioinformatics, Hoboken, N.J., Wiley-Interscience, pp. 15-32
- Friede, Tim, Dunn, Janet A., Stallard, Nigel, 2008. Clinical trials in oncology. In Missailidis, Sotiris (ed.), Anticancer therapeutics, Oxford ; Hoboken, NJ, Wiley-Blackwell, pp. 365-375
- Stallard, Nigel, Todd, Susan, 2007. Statistical methods for combining clinical trial phases II and III. In Auget, J. L.; Balakrishnan, N.; Mesbah, M.; Molenberghs, G. (eds.), Advances in Statistical Methods for the Health Sciences : Applications to Cancer and AIDS Studies, Genome Sequence Analysis, and Survival Analysis, Birkhäuser Boston, pp. 401-417
- Underwood, Martin, Antrobus, James H. L., Barkan, Kerry, Cairns, M., Ellard, David R., Griffiths, Frances, Haywood, Kirstie L., Keohane, S., Lega, C., Mars, Tom S., Sandhu, Harbinder, Stallard, Nigel, 2014. Facet-joint injections for people with persistent non-specific low back pain (FIS). Facet Injection Study Consensus Conference (FISCC), University of Warwick, UK, 27 Jun 2014
- Nicholas, R. (Richard), Chataway, Jeremy, Todd, S. C. (Susan C.), Stallard, Nigel, Valdés-Márquez, Elsa, Parsons, Nicholas R., Friede, Tim, 2009. Adaptive clinical trials incorporating treatment selection and evaluation: methodology and application in progressive multiple sclerosis. 25th Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Düsseldorf, Germany, 9-12th September 2009
- Chataway, J., Nicholas, R., Todd, S., Stallard, Nigel, Valdes-Marquez, E., Parsons, Nicholas R., Friede, Tim, 2009. Adaptive seamless trial designs in neurology: a case study in secondary progressive multiple sclerosis. 19th World Congress of Neurology, Bangkok, Thailand, October 24-30, 2009, Published in Journal of the Neurological Sciences, pp. S113-S114
- Chataway, J., Nicholas, R., Stallard, Nigel, Todd, S., Parsons, Nicholas R., Valdes-Marquez, E., Friede, Tim, 2009. Developing a new trial design in secondary progressive multiple sclerosis: a seamless adaptive approach. ABN Joint Annual Meeting with the Spanish Society of Neurology, Liverpool, England, June 22-26, 2009, Published in Journal of Neurology Neurosurgery and Psychiatry
- Stein, R. C., Makris, A., Hughes-Davies, L., Macpherson, I. R., Hall, P. S., Cameron, D. A., Earl, H. M., Pinder, S. E., Poole, C. J., Rea, D. W., McIntosh, S., Harmer, V., Morgan, A., Rooshenas, L., Conefrey, C., Donovan, J. L., Hulme, C, McCabe, Chris, Stallard, Nigel, Campbell, A. et al (Select to open full list), 2018. OPTIMA : A prospective randomized trial to validate the predictive utility and cost-effectiveness of gene expression test-directed chemotherapy decisions in early breast cancer. Cancer Research, American Association of Cancer Research
- Stein, R. C., Makris, A., Hughes-Davies, L., Bartlett, J. M. S., Marshall, A. (Andrea)?, Hall, P. S., Campbell, A., Pinder, S. E., Cameron, D. A., Rea, D., Earl, H., MacPherson, I., Poole, C., Canney, P., Francis, A., Morgan, A., Stallard, Nigel, Hulme, C., McCabe, C., Dunn, Janet A., 2015. Results of the OPTIMA (Optimal Personalized Treatment of early breast cancer usIng Multi-parameter Analysis) prelim study. European Journal of Cancer Care, Wiley-Blackwell Publishing Ltd
- Bartlett, J. M. S., Stein, R. C., Bayani, J., Marshall, A. (Andrea)?, Dunn, Janet A., Campbell, A. F., Cunningham, C., Sobol, M., Hall, P., Rooshenas, L., Morgan, A., Poole, Christopher J., Pinder, S. E., Cameron, D. A., Stallard, Nigel, Donovan, J., McCabe, C., Hughes-Davies, L., Makris, A., 2015. Comparison of multiparameter tests in the UK OPTIMA-Prelim trial. Cancer Research, American Association of Cancer Research
- Dunn, Janet A., Marshall, A. (Andrea)?, Campbell, Amy, Cameron, D., Earl, H., Macpherson, I., Poole, C., Rea, D., Francis, A., Harmer, V., Morgan, A., Stallard, Nigel, Makris, A., Hughes-Davies, L., Stein, R., 2015. Practicalities of using an adaptive design for decision making within the optima trial : optimal personalized treatment of early breast cancer using multi-parameter tests. Trials, Biomed Central Ltd
- Stein, R., Makris, A., Hughes-Davies, L., Dunn, Janet A., Bartlett, J. M. S., Donovan, J., McCabe, C., Cameron, D. A., Canney, P., Earl, H. M., Francis, A., Morgan, A., Pinder, S., Rea, D., Poole, C. J., Hall, P., Hiller, L., Stallard, Nigel, Higgins, H. B., 2012. OPTIMA prelim : optimal personalized treatment of early breast cancer using multiparameter analysis : preliminary study. Journal of Clinical Oncology, American Society of Clinical Oncology
- Parsons, Nicholas R., Friede, Tim, Todd, Susan, Stallard, Nigel, 2011. Software tools for implementing simulation studies in adaptive seamless designs : introducing R package ASD. Trials, Bio Med Central
- Friede, Tim, Parsons, Nicholas R., Stallard, Nigel, Todd, S., Valdes Marquez, E., Chataway, J., Nicholas, R., 2009. Adaptive clinical trial design for treatment selection and evaluation in multiple sclerosis (MS-Adaptive).
| Title | Funder | Award start | Award end |
|---|---|---|---|
| HORIZON-HLTH-2023-IND-06-04: Modelling and simulation to address regulatory needs in the development of orphan and paediatric medicines (INVENTS) | UK Research and Innovation | 01 Jan 2024 | 31 Dec 2028 |
| TAR 3 - Production of Technology Assessment Reviews (TAR) | National Institute for Health Research (NIHR DoH) | 01 Apr 2022 | 31 Mar 2027 |
| Efficient and unbiased estimation in adaptive platform trials | MRC | 01 Jan 2024 | 31 Dec 2026 |
| Optimal utility-based design of oncology clinical development programmes" | Janssen-Cilag Ltd | 01 Oct 2022 | 30 Sep 2026 |
| Statistical methods for interrupted clinical trials. | MRC | 01 Apr 2022 | 31 Mar 2025 |
| New adaptive platform designs for clinical trials in an emerging disease epidemic | MRC | 28 Mar 2022 | 27 Oct 2024 |
| ARC 2018: NIHR Applied Research Collaborations | National Institute for Health Research (DoH) | 01 Oct 2019 | 30 Sep 2024 |
| AWARD: RECOVERY-RS Respiratory Support: Respiratory Strategies in COVID-19; CPAP, High-flow, and standard care (link to 65887 - temp Site agreement) | National Institute for Health Research (NIHR DoH) | 01 Apr 2020 | 29 Feb 2024 |
| SLOANE atypia | National Institute for Health Research (NIHR DoH) | 01 Dec 2021 | 31 Dec 2023 |
| New adaptive platform designs for clinical trials in an emerging disease epidemic | National Institute for Health Research (NIHR DoH) | 01 Oct 2021 | 30 Sep 2023 |
| Innovative statistical methods for clinical trial pathways supporting regulatory drug approval | Boehringer Ingelheim GmbH | 01 Oct 2019 | 30 Sep 2023 |
| Research Design Service renewal 2018 | National Institute for Health Research (DoH) | 01 Oct 2018 | 30 Sep 2023 |
| OPTIMA - 8 year extension | National Institute for Health Research (DoH) | 01 Apr 2015 | 31 Mar 2023 |
| UHCW RCF funding linked to IDEATE Record 58648: Peter Kimani_Contract Extension | University Hospitals Coventry and Warwickshire NHS Trust | 01 Jun 2022 | 31 Aug 2022 |
| A Randomised, Efficient, Adaptive Clinical Trial in Surgery: Assessment of a Biodegradeable Spacer for Tears of the RotAtor Cuff Tendons (STARTS:REACTS) | National Institute for Health Research (DoH) | 01 Jan 2018 | 31 Jan 2022 |
| Role of HbA1c and 50g GCT in early detection and prediction of gestational diabetes and associated maternal and fetal complications in Thailand | MRC | 01 Apr 2018 | 31 Mar 2021 |
| UHCW RCF funding linked to IDEATE Record 39934: Peter Kimani_Contract Extension | University Hospitals Coventry and Warwickshire NHS Trust | 01 Jun 2018 | 30 May 2020 |
| Developing efficient perpetual platform trials to study multiple treatments and multiple biomarkers | MRC | 01 Feb 2017 | 31 Jan 2020 |
| Gestational hyperglycaemia in Malaysia: early screening and intervention | MRC | 03 Jan 2017 | 31 Dec 2019 |
| Risk stratification of gestational diabetes in India and Kenya. | MRC | 14 Jul 2015 | 31 Jul 2019 |
| Statistical Mentoring via LSHTM | Multiple Sclerosis Society | 01 Oct 2018 | 30 Jun 2019 |
| MRC NIRG- Estimation of intervention effects for adaptive enrichment design RCTs that incorporate identification of predictive biomarkers | MRC | 01 Jul 2016 | 30 Jun 2019 |
| MRC Methodology- Bayesian adaptive methodology for HTA trials | MRC | 01 Oct 2016 | 31 Mar 2019 |
| NIHR Research Design Service West Midlands, Warwick Hub | National Institute for Health Research (DoH) | 01 Oct 2013 | 30 Sep 2018 |
| Physiotherapy Rehabilitation for Osteoporotic VErtebral fracture trial (PROVE) - full proposal | National Institute for Health Research (DoH) | 05 Jan 2012 | 31 Mar 2018 |
| EU FP7 Health Call 2013.4.2-3 (FULL Proposal): InsPiRe - Innovative Methodology for Small Populations Research | European Commission | 01 Sep 2013 | 30 Nov 2016 |
| Bladder Path: Image directed redesign of bladder cancer treatment pathways 46647 Award re-cost - HTA Full - Biomarker Trial | National Institute for Health Research (DoH) | 01 Apr 2016 | 30 Sep 2016 |
| MS-STOP: Multiple Sclerosis stop progression trial Led by Imperial EME | National Institute for Health Research (DoH) | 01 Mar 2013 | 31 Aug 2016 |
| NIHR Doctoral Fellowship: Jo Garstang - The West Midlands | National Institute for Health Research (DoH) | 01 Sep 2010 | 31 Aug 2015 |
| REVISED SUBMISSION - NIHR HTA Feasability study 11/31 - Facet Joints | National Institute for Health Research (DoH) | 01 Jul 2013 | 30 Jun 2015 |
| Variation: West Midlands Research Design Service | National Institute for Health Research (DoH) | 02 Apr 2012 | 31 Mar 2015 |
| ICMR-MRC FULL application: Non-Communicable Disease Research Funding | MRC | 01 Nov 2011 | 31 Oct 2014 |
| Improving breast cancer detection rates through understanding and modelling the patterns of radiologist performance | Breast Cancer Campaign | 01 Oct 2011 | 30 Sep 2014 |
| MRC Capacity-Building Studentships (Maths and Stats) | MRC | 01 Oct 2009 | 30 Sep 2014 |
| Research Capability Funding Strategic Research Partnerships | University Hospitals Coventry and Warwickshire NHS Trust | 01 Mar 2013 | 31 Mar 2014 |
| NIHR Obesity Call:A Randomised controlled trial evaluating the effectiveness and cost-effectiveness @ families for health,a family based childhood obesity managment intervention delivered in a community setting for ages 7 to 11 | National Institute for Health Research (DoH) | 01 Jan 2011 | 31 Dec 2013 |
| Using Surrogate Endpoints for Decision-Making in Adaptive Seamless Designs | MRC | 01 Jan 2011 | 31 Dec 2013 |
| Distal Radius Fracture (DRAFFT) | The Human Tissue Authority (HTA) | 01 Jul 2010 | 31 Dec 2013 |
| NIHR Programme Grant - FULL - Revised: Treatment of Back Pain | National Institute for Health Research (DoH) | 01 Oct 2010 | 30 Sep 2013 |
| West Midlands Research Design Service Unit (RDSU) | National Institute for Health Research (DoH) | 01 Oct 2008 | 30 Sep 2013 |
| HTA FULL proposal: OPTIMA (Pilot Study) | National Institute for Health Research (DoH) | 01 Sep 2012 | 31 Aug 2013 |
| Adaptive seamless phase II/III designs - how should we interpret the results ? | MHRA Medicines and Healthcare products Regulatory Agency | 01 Oct 2010 | 30 Sep 2011 |
| Designing a Series of Clinical Trials | Roche Translational and Clinical Research Center (TCRC) | 01 Oct 2008 | 30 Sep 2011 |
| NHS Choices: The Psywell Study | National Institute for Health Research (DoH) | 01 Nov 2009 | 30 Apr 2011 |
| Promoting Health & Wellbeing with the Family Links Nuturing Programme (FLNP) in South Wales: An RCT and Economic Evaluation | The County Council of the City and County of Cardiff | 01 Jul 2008 | 31 Mar 2011 |
| Ethnicity, Detention and Early intervention, Reducing Inequalities and Improving Outcomes for Black and Minority Ethnic Patients - The Enrich Programme | Birmingham and Solihull Mental Health NHS Foundation Trust | 01 Apr 2007 | 31 Mar 2011 |
| MRC IES Platform: The Development of an Intervention to promote walking in primary | MRC | 01 Jun 2008 | 30 Nov 2010 |
| Research Registrar Post for the Emergency, Planning Clinical Leadership Advisory Group Triage Project - Big Bang Incidents, Conventional and CBRN | Department of Health | 05 Jan 2009 | 04 Jan 2010 |
| Refining the Trial Design for Adaptive Treatment Selection in MS | Multiple Sclerosis Society | 01 Oct 2009 | 31 Dec 2009 |
| Qualification and Assessment of Prefereneces of Patients and Professionals for Different Modes of Dialysis Therapy | University Hospitals Coventry and Warwickshire NHS Trust | 01 Nov 2008 | 31 Dec 2009 |
| SUDI 21 Pilot Project | Coventry Primary Care Trust | 01 Sep 2008 | 31 Aug 2009 |
| Research Registrar Post for the Emergency, Planning Clincal Leadership Advisory Group Triage Project - Big Bang Incidents, Conventional & CBRN | Department of Health | 07 Jul 2008 | 03 Jul 2009 |
| Adaptive clinical trial design for treatment selection and evaluation in multiple sclerosis | Multiple Sclerosis Society | 01 Jun 2008 | 28 Feb 2009 |
| Third Amendment to Consulting Agreement - Statistical Design Analysis | Hoffmann-La Roche | 21 Dec 2007 | 31 Dec 2008 |
| Proposal for Further Investigations to Support the Adoption of the Fixed Concentration Procedure for Assessing Acute Inhalation Toxicity (TG433) in the EU. | National Centre for the Replacement, Refinement and Reduction of Animals in Research | 01 Jul 2008 | 31 Oct 2008 |
| Statistical design analysis - Continuation | Hoffmann-La Roche | 01 Oct 2005 | 31 Dec 2007 |
| Statistical Design and Clinical Trial Simulation for Pfizer Study | Pfizer Limited | 01 Feb 2007 | 30 Jun 2007 |
| Continuation - Statistical Design Analysis for Hoffmann - La Roche. | Hoffmann-La Roche | 01 Oct 2005 | 31 Mar 2007 |
| Biostatistical Analysis of the Draft Guideline TG433 for Acute Inhalation Toxicity Studies (fixed concentration procedure) | Organisation for Economic Cooperation and Development | 15 Jul 2006 | 31 Jul 2006 |
| Statistical Design Analysis for Hoffmann-La Roche | Hoffmann-La Roche | 01 Dec 2005 | 31 Dec 2005 |