Events Calendar
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Mon 29 Apr, '24- |
WMS/BMS Seminar: The (Good) Life of a Scientific Editor, Dr Alejandro Montenegro Montero, Executive Editor, Cold Spring Harbor Laboratory (CSHL), USAIBRB Lecture Theatre |
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Tue 7 May, '24- |
SLS & WMS Microbiology and Infectious Diseases SeminartbcSLS & WMS Microbiology and Infectious Diseases Seminar Series Check webpage for updated venue informatiojn |
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Wed 15 May, '24- |
WMS - BMS Seminar: Professor Steffen Scholpp FRSB, Living System Institute, Biosciences, University of ExeterIBRB Lecture Theatre |
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Tue 21 May, '24- |
SLS & WMS Microbiology and Infectious Diseases SeminartbcSLS & WMS Microbiology and Infectious Diseases Seminar Series Check webpage for updated venue informatiojn |
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Wed 29 May, '24- |
Forum for Leaders of Inclusive Cultures - Menopause Is an Inclusion Issue |
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Tue 4 Jun, '24- |
SLS & WMS Microbiology and Infectious Diseases SeminartbcSLS & WMS Microbiology and Infectious Diseases Seminar Series Check webpage for updated venue informatiojn |
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Thu 6 Jun, '24- |
WIHEA Masterclass: Exploring Trauma-informed Approaches in Higher EducationTeaching Grid |
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Tue 18 Jun, '24- |
SLS & WMS Microbiology and Infectious Diseases SeminartbcSLS & WMS Microbiology and Infectious Diseases Seminar Series Check webpage for updated venue informatiojn |
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Wed 26 Jun, '24- |
WMS - BMS Seminar: Dynamics and mechanics of epithelial cells in 2D and 3D, Professor Andreas Janshoff, Institute of Physical Chemistry, University of GottingenMTC Lecture Theatre, Warwick Medical School, Gibbet Hill campusAbstract: We performed experiments involving indentation-retraction/relaxation to observe the viscoelastic properties of epithelial cells undergoing shape alterations. MDCK II cells cultured on flexible polydimethylsiloxane substrates underwent lateral stretching, resulting in increased cortex contractility and reduced excess surface area. Consequently, cells maintained their fluidity but became inherently stiffer. This behavior was consistent across demixed cell monolayers of ZO-1/2 double knockdown (dKD) cells, cells exposed to varying temperatures, and following cholesterol removal from the plasma membrane. Conversely, individually tested cells adhered to differently sized patches showed no significant rheological changes. By sacrificing excess surface area, cells gained the ability to respond to mechanical challenges without compromising their fluidity, thus acquiring newfound flexibility that elucidates the fluidity-stiffness relationship. |
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