At a Glance
|Date:||10 February 2012|
|Location:||GLT2, School of Life Sciences|
|Open To:||Staff, students, alumni and general public|
|Summary:||Professor Timothy A. Cross seminar on The Native-Like Structure of the M2 Proton Channel of Influenza A obtained from Lipid Bilayer Preparations.|
Professor Timothy A. Cross, Director of the Nuclear Magnetic Resonance Programme, National High Magnetic Field Laboratory, Tallhassee, Florida, will be speaking on 'The Native-Like Structure of the M2 Proton Channel of Influenza A obtained from Lipid Bilayer Preparations'. Professor Cross is The British Biophysical Society International Lecturer of 2012.
A comparison of 8 structures of M2 deposited in the PDB from solution NMR in detergent micelles, x-ray crystallography with M2 in an octylglucoside and polyethylene glycol environment, as well as solid state NMR of oriented samples in liquid crystalline lipid bilayers. A detailed mechanism for the shuttling of protons across the viral membrane will be described based on the structural, biochemical and physiological data. In addition recent spectra of M2 in E. coli membranes will be shown and prospects for using such spectra in structural characterization and in structural validation will be discussed.
For further information contact Leanne Bull leanne dot bull at warwick dot ac dot uk, Science Support Assistant, School of Life Sciences.