Departmental news

First year LLB students Siara Parveen and Charlotte Neal, successfully completed the regional semi-final of the Student Client Interviewing Competition (CIC) held in Sheffield earlier this month. “It was definitely unexpected, but we are both really proud of ourselves [...and] absolutely delighted.”

WMG is delighted at the news that Britishvolt have been purchased by Recharge.

Professor David Greenwood, Director of Industrial Engagement at WMG, University of Warwick said: “This is great news for the UK, allowing us to capitalise on the value realised under the previous ownership. High value jobs will be protected and created in the UK as a result of this purchase - not just in the company, but in its upstream and downstream supply chains.
 
“For the UK to remain globally competitive, it is critical that we establish a strong battery manufacturing base to support many of our key industrial sectors, including automotive, aerospace, rail, marine and energy storage.”

WMG looks forward to continuing to support the growth of the UK battery industry.

Read more about the news here: https://www.bbc.co.uk/news/business-64754879

Liquid biopsies of circulating tumor cells (CTCs) have the potential to transform cancer management through non-invasive, real-time feedback on patient conditions. However, immunoaffinity-based liquid biopsies typically suffer from low throughput, relative complexity, and postprocessing limitations. Here, we addressed these issues simultaneously by decoupling and independently optimizing the nano-, micro-, and macro-scales of an enrichment device that is simple to fabricate and operate. Unlike other affinity-based devices, our scalable mesh approach enables optimum capture conditions at any flow rate. The device detected CTCs under experimental conditions and in the blood of cancer patients where it also allowed for postprocessing and, thus, identification of clinically relevant biomarkers such as HER2, but also has the potential to predict patient response to therapies such as immune checkpoint inhibition therapy in the future. This suggests that our approach can overcome major limitations associated with affinity-based liquid biopsies and help improve cancer management.

Read the paper hereLink opens in a new window.

Bacillus cereus G9241 was isolated from a Louisiana welder suffering from an anthrax-like infection. The organism carries two transcriptional regulators that have previously been proposed to be incompatible with each other in Bacillus anthracis: the pleiotropic transcriptional regulator PlcR found in most members of the Bacillus cereus group but truncated in all B. anthracis isolates, and the anthrax toxin regulator AtxA found in all B. anthracis strains and a few B. cereus sensu stricto strains. Here we report cytotoxic and haemolytic activity of cell free B. cereus G9241 culture supernatants cultured at 25 °C to various eukaryotic cells. However, this is not observed at the mammalian infection relevant temperature 37 °C, behaving much like the supernatants generated by B. anthracis. Using a combination of genetic and proteomic approaches to understand this unique phenotype, we identified several PlcR-regulated toxins to be secreted highly at 25 °C compared to 37 °C. Furthermore, results suggest that differential expression of the protease involved in processing the PlcR quorum sensing activator molecule PapR appears to be the limiting step for the production of PlcR-regulated toxins at 37 °C, giving rise to the temperature-dependent haemolytic and cytotoxic activity of the culture supernatants. This study provides an insight on how B. cereus G9241 is able to ‘switch’ between B. cereus and B. anthracis–like phenotypes in a temperature-dependent manner, potentially accommodating the activities of both PlcR and AtxA.

Read the paper hereLink opens in a new window.

Bacillus cereus G9241 was isolated from a welder who survived a pulmonary anthrax-like disease. Strain G9241 carries two virulence plasmids, pBCX01 and pBC210, as well as an extrachromosomal prophage, pBFH_1. pBCX01 has 99.6% sequence identity to pXO1 carried by Bacillus anthracis and encodes the tripartite anthrax toxin genes and atxA, a mammalian virulence transcriptional regulator. This work looks at how the presence of pBCX01 and temperature may affect the lifestyle of B. cereus G9241 using a transcriptomic analysis and by studying spore formation, an important part of the B. anthracis lifecycle. . Here we report that pBCX01 has a stronger effect on gene transcription at the mammalian infection relevant temperature of 37˚C in comparison to 25˚C. At 37˚C, the presence of pBCX01 appears to have a negative effect on genes involved in cell metabolism, including biosynthesis of amino acids, whilst positively affecting the transcription of many transmembrane proteins. The figure below shows the first image of the anthrax G9241 cross-over strain linear chromosome bacteriophage (unusual in bacteriophage itself).

Read the paper hereLink opens in a new window.

Writing about web page https://warwick.ac.uk/fac/arts/hrc/confs/territorialbodies/

On the 15th of February 2023, the Royal Society hosted an event for British Academy Fellows from Ukraine, which was attended by fellows from the WLS research team – Dr Aisel Omarova and Dr Maryna Utkina.

Taskmaster creator and co-presenter ‘little’ Alex Horne has provided a recorded testimonial about Warwick Law School’s Dr Ali Struthers and the hard work and commitment she has shown to the School Tasking project. “The work that Ali has been doing […] has been genuinely remarkable.” Watch the full video testimonialLink opens in a new window.

Writing about web page https://warwick.ac.uk/fac/arts/hrc/confs/territorialbodies/