Mary Weston was an eighteenth-century Quaker preacher and missionary, who undertook extensive ministerial work in the British Isles and the American Colonies. Ceding domestic responsibilities to a husband was highly unusual for an eighteenth-century woman. This Brief Life therefore intends to contextualise not only the mechanisms of support within Quakerism that were provided for Mary throughout her ministerial career, but also the relationships that developed with her husband and daughter as a result of her frequent calls to ministry.