Callan Littlejohn
PhD project
Evaluation of the capabilities of 2D Mass Spectrometry in a variety of molecular systems
External Partner
Verdel Instruments
Research focus
Working as part of the O'Connor Group, in the Millburn House ICR laboratory, my main focus is working on Two-Dimensional Mass Spectrometry, 2DMS is a truly data MS/MS independent technique that correlates fragment ions to their respective precursor m/z without the need for any isolation by passing ions through a fragmentation zone.
In order to gain a fuller comprehension of the processes involved in 2DMS i chose to focus on the fundamentals of Fourier Transform Mass Spectrometry. My initial studies focussed on confirming the Felgett effect in 2DMS, this work allowed for the development of an algorithm to confirm minimum sizes for acquisition of 2DMS. Recently my focus has been more centered around method development.
Links
Publications
In-Silico Demonstration of Two Dimensional Mass Spectrometry using Spatially Dependent Fragmentation, JASMS, 2023 doi:https://doi.org/10.1021/jasms.2c00241
Conferences
BMSS Sept. 2021: gave a digital poster "Fellgett signal averaging in 2DMS"
ASCDT Sept 2021: gave a virtual presentation "Fellgett signal averaging in 2DMS"
TCT 3SIXTY sept 2021
Interplas sept 2021
LabInnovations Nov 2021
ASMS Jun 2022: poster "2DMS in a variety of systems"
ASCDT Jun 2022: poster "Short 2DMS of Covid-19"
EFTMS Jul 2022: Presentation "On the nature of Space charge: observations of dark charge effects"
IMSC Aug 2022: poster "2DMS in a variety of systems"
BMSS sept 2022: presentation: "2DMS in every mass analyser"
LabInnovations Nov 2022
Warwick Microbiology Cluster Meeting presentation "Two Dimensional Mass Spectrometry"
Warwick Chemistry Postgraduate symposium May 2023 presentation "Two Dimensional
Mass Spectrometry in every mass analyzer"
ASMS June 2023 Poster "Hyphenation of Trapped Ion Mobility with Two Dimensional Mass Spectrometry"
BMSS Sept 2023 Oral "Touchstone 2DMS: advanced Post-Processing for FTMS"
Grants and Prizes
John Beynon Travel grant: awarded by BMSS 2022
Nico Nibbering Student travel award awarded by IMSF 2022
Best Oral Presentation in stream B Warwick Postgraduate Symposium
John Beynon Travel grant awarded by BMSS 2023
Professional Memberships
Royal Society of Chemistry (AMRSC)
BMSS (Student Member)
ASMS (Student Member)
Get in touch!
Find me at Millburn House