We focus on development and applications of solid-state and solution NMR to study structure, dynamics and interactions of biological systems in the context of integrated structural biology. We are associated with the Warwick solid-state NMR grouping and Chemical Biology Research Facility.
We develop methods to probe structure and dynamics of molecules.
We apply both solid- and solution-state NMR to various biomolecular systems.
Structural biology and engineering of natural products biosynthetic machinery.
Experimental determination and simulation of molecular motion.
Understanding modes of action and facilitating designing new antibiotics.
(NMR hall in Millburn House)
The group uses mostly 500 MHz (various MAS probes from 4 mm to 1.3 mm), 600 MHz (various MAS probes from 4 mm to 1.3 mm, a unique 0.8 mm 100 kHz probe from Ago Samoson). We are also frequent users of the National 850 MHz Solid-State NMR Facility.
(NMR hall in MAS building - left to right: solid-state NMR: 700 MHz WB spectrometer with 0.7, 1.3 and 3.2 mm MAS probes, solution NMR: 500 MHz, 600 MHz, 700 MHz with cryoprobe).
The group is the main user of the ERC & UW funded 700 MHz solid-state NMR spectrometer and frequent users of 700 MHz and 600 MHz solution NMR spectrometers.