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School of Engineering

Publications

  • H. Yu , L. Weaver, S. Saffaran, R. Tonelli, L.S. Menga, Q. Zhang, J.G. Laffey, L. Camporota, T.E. Scott, A.M. Esquinas, D.L. Grieco, M. Antonelli, E Clini, and D.G. Bates, "External validation of machine learning models for identifying patients at risk of failing non-invasive ventilation", submitted.

  • S. Mistry, S. Saffaran, B. Brook, J.G. Hardman, J.G. Laffey, L. Rose, L. Camporota, T.E. Scott, and D.G. Bates, "Ventilator Induced Lung Injury with Airway Pressure Release Ventilation versus Pressure-Controlled Ventilation", submitted.

  • H. Shamohammadi, L. Weaver, S. Saffaran, R. Tonelli, M. Laviola, J.G. Laffey, L. Camporota, T.E. Scott, J.G. Hardman, E. Clini, and D.G. Bates, "Positive end expiratory pressure generated by high flow nasal cannula therapy in patients with acute hypoxemic respiratory failure", submitted.
  • H. Yu, L. Weaver, S. Saffaran, R. Tonelli, J.G. Laffey, L. Camporota, T.E. Scott, J.G. Hardman, E.M. Clini, and D.G. Bates, "Machine learning models predict non-invasive ventilation outcome prior to its initiation", abstract to be presented at the 2ndPLUG Physiology Symposium, Boston, September 2024.

  • L. Weaver, H. Shamohammadi, S. Saffaran, R. Tonelli, M. Laviola, J.G. Laffey, L. Camporota, T.E. Scott, J.G. Hardman, E.M. Clini, and D.G. Bates, "Digital twins of acute hypoxic respiratory failure patients suggest a mechanistic basis for success and failure of non-invasive ventilation", Critical Care Medicine, 10.1097, 2024.

  • S. Mistry, T.E. Scott, B. Jugg, R. Perrott, S. Saffaran, and D.G. Bates, “An in-silico porcine model of phosgene-induced lung injury predicts clinically relevant benefits from application of continuous positive airway pressure up to 8 hours post exposure”, Toxicology,https://doi.org/10.1016/j.toxlet.2023.12.005,2023.
  • L. Weaver, S. Saffaran, D. Hannon, T.E. Scott, J.G. Laffey, J.G. Hardman, D.G. Bates, “The Hydrostatic Effects of Prone and Supine Positioning: Model Development”, BioMedEng23, Sep 2023, Swansea, UK.
  • S. Mistry, B.S. Brook, S. Saffaran, D.M. Hannon, J.G. Laffey, T.E. Scott, J.G. Hardman, D.G. Bates, “Improved Optimisation Method for a Cardio-pulmonary Simulator to Individual Patient Data”, BioMedEng23, Sep 2023, Swansea, UK.
  • C.S. Barakat, K. Sharafutdinov, J. Busch, S. Saffaran, D.G. Bates, J.G Hardman, A. Schuppert, S. Brynjólfsson, S. Fritsch and M. Riedel, "Developing an Artificial Intelligence-Based Representation of a Virtual Patient Model for Real-Time Diagnosis of Acute Respiratory Distress Syndrome", Diagnostics, Special Issue on AI-Driven Intelligent Health Care Diagnostic Solutions, 13(12), 2098, 2023.
  • K. Sharafutdinov, S.J. Fritsch, M. Iravani, P.F. Ghalati, S. Saffaran, D.G. Bates, J.G. Hardman, R. Polzin, H. Mayer, G. Marx, J. Bickenbach and A. Schuppert, "Computational simulation of virtual patients reduces dataset bias and improves machine learning-based detection of ARDS from noisy heterogeneous ICU datasets", IEEE Open Journal of Engineering in Medicine and Biology, Special Issue on Computational Modeling & Digital Twin Technology in Biomedical Engineering, 2023.
  • L. Weaver, S. Saffaran, M. Chikhani, J.G. Laffey, T.E. Scott, L. Camporota, J.G. Hardman, and D.G. Bates,"Why reduced inspiratory pressure could determine success of non-invasive ventilation in acute hypoxic respiratory failure", in proceedings of the 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Glasgow, July 2022.
  • S. Mistry, B.B. Brook, S. Saffaran, M. Chikhani, D. Hannon, J.G. Laffey, T.E. Scott, L. Camporota, J.G. Hardman, and D.G. Bates, "A computational cardiopulmonary physiology simulator accurately predicts individual patient responses to changes in mechanical ventilator settings", in proceedings of the 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Glasgow, July 2022.
  • T.C. Kwok, C. Henry, S. Saffaran, M. Meeus, D.G. Bates, D. Van Laere, G. Boylan, J.P. Boardman, and D. Sharkey, "Application and potential of artificial intelligence in neonatal medicine", Seminars in Fetal and Neonatal Medicine,DOI:https://doi.org/10.1016/j.siny.2022.101346, 2022.
  • S. Mistry, A. Das, S. Saffaran, L. Camporota, T.E. Scott, J.G. Hardman, N. Yehya and D.G. Bates, "Validation of at-the-bedside formulae for estimating ventilator driving pressure during airway pressure release ventilation using computer simulation", Respiratory Research, 23:101, https://doi.org/10.1186/s12931-022-01985-z, 2022.
  • L. Weaver, A. Das, S. Saffaran, N. Yehya, M. Chikhani, T.E. Scott, J.G. Laffey, J.G. Hardman, L. Camporota and D.G. Bates, "Optimising respiratory support for early COVID-19 pneumonia: a computational modelling study", British Journal of Anaesthesia, 128(6):1052e1058, 2022.
  • D. Hannon, S. Mistry, A. Das, S. Saffaran, J.G. Laffey, B.S. Brook, J.G. Hardman and D.G. Bates, "Modeling mechanical ventilationin silico– potential and pitfalls", Seminars in Respiratory and Critical Care Medicine, Special Issue on Mechancial Ventilation, DOI: https://doi.org/ 10.1055/s-0042-1744446, 2022.
  • L.Weaver, A.Das,S.Saffaran,N.Yehya,T.E.Scott,M.Chikhani,J.G.Laffey,J.G.Hardman,L.Camporotaand D.G.Bates, "High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational study", Annals of Intensive Care, 11:109,2021.
  • A. Das, S. Saffaran, M. Chikhani, T.E. Scott, M. Laviola, N. Yehya, J.G. Laffey, J.G. Hardman, and D.G. Bates, "In silico modeling of COVID-19 ARDS: pathophysiological insights and potential management implications", Critical Care Explorations, DOI:10.1097/CCE.0000000000000202, 2020.
  • S. Saffaran, A. Das, J.G. Laffey, J.G. Hardman, N. Yehya and D.G. Bates, "Utility of driving pressure and mechanical power to guide protective ventilator settings in two cohorts of adult and pediatric patients with acute respiratory distress syndrome: A computational investigation", Critical Care Medicine, DOI:10.1097/CCM.0000000000004372, 2020.
  • S. Saffaran, A. Das, J.G. Hardman, N. Yehya and D.G. Bates, "High-fidelity Computational Simulation to Refine Strategies for Lung-Protective Ventilation in Paediatric Acute Respiratory Distress Syndrome", Intensive Care Medicine,https://doi.org/10.1007/s00134-019-05559-4, 2019.
  • S. Saffaran, W. Wang, A. Das, W. Schmitt, J.G. Hardman, G. Weimann and D.G. Bates, "An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation", CPT Pharmacometrics & Systems Pharmacology, DOI: 10.1002/psp4.12308, 2018.
  • S. Saffaran, A. Das, J.G. Hardman, N. Yehya, and D.G. Bates, "Development and Validation of a Computational Simulator for Pediatric ARDS Patients", in proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, JeJu Island, S. Korea, 2017.