Regulation of cell function has become increasingly complex with the emergence of flouresence studies demonstrating extensive active protein movement and protein localisation within cells. This can be transient, for example under cell signalling, or intrinsic to a cellular process where cell compartmentalisation is used to segregate proteins. This is a multidisciplinary meeting with theory (modelling), computation and experiment represented. Topics include cytoskeleton dynamics (eg motility), spatial-temporal compartmentalisation in signalling (eg the immunological synapse), and transport and protein targetting (golgi/ER).

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All talks to be held in the Mathematics Institute

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Monday 24th May (room MS02)
Cell Environment & Traffic
10.00-10.55	Coffee from 10.00
10.55-11.50	Weitz (Harvard), Mechanical properties of cells
11.50-12.40	Hawes (Oxford), Movement in the plant secretory pathway
12.40-14.00	Lunch
Cytoskeleton Dynamics
14.00-14.50	Carlier (Gif-sur-Yvette), A biomimetic motility assay provides insight into the molecular mechanism of actin-based motility
14.50-15.40	Mogilner (California), Computational models of migrating keratocyte cells
15.40-16.15	Tea
Cell Environment & Traffic
16.15-17.05	Stephens (Bristol), Analysis of membrane traffic in mammalian cells using live cell imaging
20.00	Dinner at The Village Hotel, Coventry
Tuesday 25th May (room MS02)
Signalling & Spatial Enrichment
09.25-10.20	Dustin (New York), Molecular sorting within the helper T lymphocyte immunological synapse
10.20-11.00	Burroughs (Warwick), Mathematics, mechanisms and consequences of spatial segregation
11.00-11.30	Coffee
11.30-12.20	Squire (Heidelberg), Tba
12.20-13.10	White (Liverpool), Real-time imaging of the dynamics of NF-kappaB signalling
13.10-14.30	Lunch
Rafts
14.30-15.20	Harder (Oxford), A dynamic T cell receptor signalling machinery in plasma membrane domains
15.20-16.10	Lundbaek (Copenhagen), Cholesterol-induced protein sorting: an analysis of energetic feasibility
16.10-16.40	Tea
16.40-17.30	Nichols (Cambridge), Lipid rafts; structure and function
19.30	Dinner at The Thai Elephant, Warwick
Wednesday 26th May (room MS04)
Signalling and Spatial Enrichment
09.25-10.20	Kupfer (National Jewish Medical and Research Centre), Spatial-temporal coordination of signaling in SMACs
10.20-11.10	Wulfing (Texas), A function for the accumulation of the T cell receptor at the center of the T cell/APC interface
11.10-11.40	Coffee
Cytoskeleton & Cell Movement
11.40-12.30	Dembo (Boston), Dynamics of the traction forces in fibroblastic cells
12.30-13.20	Landree (John Hopkins), The cell compass, understanding how cells sense a gradient
13.20-13.30	Closing remarks
13.30-15.30	Lunch and discussion

Seminar organiser: Nigel Burroughs