Funded by a c€4.5m SysMO grant (Warwick share approx £1.5m, PI: Liz Wellington) to:
understand pathway networking in a complex oligotroph where there are clear links between primary and secondary metabolism (antibiotic and other bioactive metabolite production)
determine the utilisation networks of phosphate, carbon and nitrogen, from environment monitoring (eg PhoP/PhoR for phosphate), through to their impact on the secondary metabolism profiles, incorporating restructuring of primary metabolism (e.g. catabolism network regulation); and
determine the integration and convergence of regulatory pathways.
WSB Staff: Burroughs, Hodgson, Rand, Wellington and Wild
Collaborators: M C M Smith (Aberdeen), W Wohlleben (Tubingen), K Nieselt (Tubingen), L Dijkhuizen (Groningen), R Breitling (Groningen), E Takano (Groningen), J F Martin (INBIOTEC), T E. Ellingsen (NTNU)