Systems Medicine
Developing computational models to better understand various aspects of pulmonary and cardiovascular pathophysiology. Specific applications include:
- Modeling physiology of critically ill patients suffering from Acute Respiratory Distress Syndrome, Chronic Obstructive Pulmonary Disease, etc.
- Investigation of critical safety and efficacy questions with respect to mechanical ventilation in the Intensive Care for Adults, Pediatrics, and Neonates
- Patient-specific simulation technologies to be implemented in the Intensive Care Unit
- Modeling and simulation in the drug development process to inform crucial decisions such as dosing, drug interaction, etc.
- Design protocols to test investigative and therapeutic maneuvers such as fluid resuscitation, and ventilator strategies, in emergency and critical care scenarios such as blast lung injury.
Anup successfully completed a Ph.D. in Systems Engineering at the University of Exeter in 2012 and joined the department as an associate research fellow. Since 2013, he has been a post-doctoral research associate in the School of Engineering at the University of Warwick.
Anup has worked on collaborative projects with various academic and industrial bodies including the University of Nottingham, University College London, Bayer Pharmaceuticals, Fisher and Paykel, Medtronic, Ministry of Defence, among others.
Anup was born in India and completed his schooling in London. He attended Richmond upon Thames College in London to study A Levels in Maths, Further Maths and Physics. He subsequently achieved a first class with honours MEng degree in Electronic and Software Engineering from the University of Leicester in 2007. He is fluent in multiple languages including English, Hindi, and Malayalam. He is a member of the IEEE and WMAHSN.
- 'Mistry, Sonal, 'Das, Anup, 'Hardman, Jonathan G., 'Bates, Declan G., 'Scott, Timothy E., 2022. 'Pre-hospital continuous positive airway pressure after blast lung injury and hypovolaemic shock : a modelling study. British Journal of Anaesthesia, 128 (2), pp. E151-E157
- 'Hannon, David M., 'Mistry, Sonal, 'Das, Anup, 'Saffaran, Sina, 'Laffey, John G., 'Brook, Bindi S., 'Hardman, Jonathan G., 'Bates, Declan G., 2022. 'Modeling mechanical ventilation in silico?potential and pitfalls. Seminars in Respiratory and Critical Care Medicine, 43 (3), pp. 335-345
- Weaver, Liam, Das, Anup, Saffaran, Sina, Yehya, Nadir, Chikhani, Marc, Scott, Timothy E., Laffey, John G., Hardman, Jonathan G., Camporota, Luigi, Bates, Declan G., 2022. Optimising respiratory support for early COVID-19 pneumonia : a computational modelling study. British Journal of Anaesthesia, 128 (6), pp. 1052-1058
- Saffaran, Sina, Das, Anup, Hardman, Jonathan G., Yehya, Nadir, Bates, Declan, 2019. High-fidelity computational simulation to refine strategies for lung-protective ventilation in paediatric acute respiratory distress syndrome. Intensive Care Medicine, 45, pp. 1055-1057
- Das, Anup, Camporota, Luigi, Hardman, Jonathan G., Bates, Declan G., 2019. What links ventilator driving pressure with survival in the acute respiratory distress syndrome? A computational study. Respiratory Research, 20 (1)
- Haque, Mainul, Das, Anup, Scott, Timothy E., Bates, Declan, Hardman, J. G., 2018. Primary blast lung injury simulator : a new computerised model. Journal of the Royal Army Medical Corps
- Laviola, Marianna, Das, Anup, Bates, Declan G., Hardman, Jonathan G., 2018. Computational modelling of oxygen insufflation during apnoea in obesity.. European Respiratory Journal
- Saffaran, Sina, Wang, Wenfei, Das, Anup, Schmitt, Walter, Becker-Pelster, Eva-Maria, Hardman, Jonathan G., Weimann, Gerrit, Bates, Declan, 2018. Inhaled sGC modulator can lower PH in patients with COPD without deteriorating oxygenation. CPT: pharmacometrics & systems pharmacology, 7 (8), pp. 491-498
- Das, Anup, Haque, Mainul, Chikhani, Marc, Cole, Oana, Wang, Wenfei, Hardman, Jonathan G., Bates, Declan, 2017. Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome. BMC Pulmonary Medicine, 17
- Chikhani, M., Das, Anup, Haque, M., Wang, Wenfei, Bates, Declan G., Hardman, J. G., 2016. High PEEP in acute respiratory distress syndrome: quantitative evaluation between improved arterial oxygenation and decreased oxygen delivery. British Journal of Anaesthesia, 117 (5), pp. 650-658
- Chikhani, M., Das, Anup, Haque, M., Wang, Wenjie, Bates, Declan, Hardman, J. G., 2016. High PEEP in ARDS : quantitative evaluation between improved oxygenation and decreased oxygen delivery. British Journal of Anaesthesia, 117 (5), pp. 650-658
- Das, Anup, Cole, Oana, Chikhani, Marc, Wang, Wenfei, Ali, Tayyba, Haque, Mainul, Bates, Declan, Hardman, Jonathan G., 2015. Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation. Critical Care, 19 (1)
Title | Funder | Award start | Award end |
---|---|---|---|
COVID-19: Optimising Mechanical Ventilation in COVID-19 via Computational Simulation of Virtual Patients | UK Research and Innovation | 22 Jun 2020 | 21 Dec 2021 |
Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit: Realising Industrial and Medical Applications | EPSRC | 01 Jul 2017 | 30 Nov 2021 |