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Identification of diagnostic markers for severe disease risk in Helicobacter pylori-infected patients

Monash Warwick Alliance Catalyst Fund May 2018 Round

Gastric cancer is a major global health issue. It is the third leading cause of cancer deaths worldwide, with almost one million new cases arising each year and a five-year survival rate of 20-30%. Exploring new ways to provide better diagnosis and treatment of this potentially deadly disease is something medical professionals over the world are seeking to achieve.

Through the Alliance, the team of Dr Terry Kwok-Schuelein, Senior Lecturer in Biochemistry and Molecular Biology from Monash University and Dr Mark Achtman, Professor from the Warwick Medical School at the University of Warwick have the unique opportunity to explore one of the most common human pathogens, Helicobacter pylori (or H. pylori in short). H. pylori resides in the stomach of almost 50% of the human population. Although H. pylori infection does not cause illness in most infected people, the bacterium can trigger damage to the stomach lining and cause long-term inflammation or even tissue deterioration, leading to 50% of gastric cancer cases worldwide. The questions surrounding whether it is predestined in our genes for H. pylori infection to cause disease, or whether a disease outcome is influenced by the genes of the bacterium, or both, forms the basis of this collaborative global study.

Dr Kwok-Schuelein and Dr Achtman will lead a team to share skills, expertise and knowledge to tackle this global health issue. By combining bacterial genomics expertise at Warwick with the H. pylori pathogenesis and human genomics expertise at Monash, a unique opportunity has been created to assess the role of the relationship between human and H. pylori genetics in the development of H. pylori-associated disease.

The knowledge gained will achieve significant steps forward in the identification of carriers of the H. pylori bacteria who are at risk of adverse health outcomes even before symptoms appear. It will also assist in the selection of who should be targeted for eradication therapy and endoscopy.

Principal Applicants:
Dr Terry Kwok-Schuelein Professor Mark Achtman 

Dr Terry Kwok-Schuelein

Senior Lecturer, School of Biomedical Sciences

Monash University

Professor Mark Achtman

Professor, Warwick Medical School (WMS)

University of Warwick


Dr Rebecca Gorrell

Research Fellow, School of Biomedical Sciences

Monash University

Professor Lawrence Young

Pro Dean (External Affairs), Warwick Medical School (WMS)

University of Warwick

Dr Moeen Riaz

Research Fellow, School of Public Health & Preventive Medicine

Monash University

Professor Xavier Didelot

Professor, Department of Statistics

University of Warwick