Job Title
Professor of Molecular Oncology
Department
WMS - Biomedical Sciences
- Dawood, Muhammad, Vu, Quoc Dang, Young, Lawrence S., Branson, Kim, Jones, Louise, Rajpoot, Nasir M., Minhas, Fayyaz ul Amir Afsar, 2024. Cancer drug sensitivity prediction from routine histology images. npj Precision Oncology, 8 (1)
- Dawood, Muhammad, Eastwood, Mark, Jahanifar, Mostafa, Young, Lawrence S., Ben-Hur, Asa, Branson, Kim, Jones, Louise, Rajpoot, Nasir M., Minhas, Fayyaz ul Amir Afsar, 2023. Cross-linking breast tumor transcriptomic states and tissue histology. Cell Reports Medicine, 4 (12)
- Velapasamy, S., Lo, K. W, Chung, G. T. Y., Tsang, C. M., Dawson, C. W., Young, L. S., Tsao, S. W., Paterson, I., Yap, L. F., 2022. Disruption of TGF-? signalling supports EBV infection in epithelial cells : role in the pathogenesis of nasopharyngeal carcinoma. Journal of Pathology
- Elmetwali, Taha, Salman, Asmaa, Wei, Wenbin, Hussain, Syed A., Young, Lawrence S., Palmer, Daniel H., 2020. CD40L membrane retention enhances the immunostimulatory effects of CD40 ligation. Scientific Reports, 10 (1)
- Zhang, Wen-Ying, Banerjee, Samya, Imberti, Cinzia, Clarkson, Guy J., Wang, Qian, Zhong, Qian, Young, Lawrence S., Romero-Canelón, Isolda, Zeng, Musheng, Habtemariam, Abraha, Sadler, Peter J., 2020. Strategies for conjugating iridium(III) anticancer complexes to targeting peptides via copper-free click chemistry. Inorganica Chimica Acta, 503
- Song, Hualong, Rogers, Nicola J., Allison, Simon J., Brabec, Viktor, Bridgewater, Hannah, Kostrhunova, Hana, Markova, Lenka, Phillips, Roger M., Pinder, Emma C., Shepherd, Samantha L., Young, Lawrence S., Zajac, Juraj, Scott, Peter, 2019. Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification. Chemical Science, 10 (37), pp. 8547-8557
- Lung, Raymond W-M., Hau, Pok-Man, Yu, Ken H-O., Yip, Kevin Y., Tong, Joanna H-M., Chak, Wing-Po, Chan, Anthony W-H., Lam, Ka-Hei, Lo, Angela Kwok-Fung, Tin, Edith K-Y., Chau, Shuk-Ling, Pang, Jesse C-S., Kwan, Johnny S-H., Busson, Pierre, Young, Lawrence S., Yap, Lee-Fah, Tsao, Sai-Wah, To, Ka-Fai, Lo, Kwok-Wai, 2018. EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma. The Journal of Pathology, 244 (4), pp. 394-407
- Lo, Angela Kwok-Fung, Lung, Raymond Wai-Ming, Dawson, Christopher W., Young, Lawrence S., Ko, Chuen-Wai, Yeung, Walter Wai, Kang, Wei, To, Ka-Fai, Lo, Kwok-Wai, 2018. Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma. Journal of Pathology, 246 (2), pp. 180-190
- Morris, Mhairi, Laverick, Louise, Wei, Wenbin, Davis, Alexandra, O'Neill, Samantha, Wood, Liam, Wright, Jack, Dawson, Christopher, Young, Lawrence, 2018. The EBV-encoded oncoprotein, LMP1, induces an Epithelial-to-Mesenchymal Transition (EMT) via Its CTAR1 domain through integrin-mediated ERK-MAPK signalling. Cancers, 10 (5)
- Velapasamy, Sharmila, Dawson, Christopher W., Young, Lawrence S., Paterson, Ian C., Yap, Lee Fah, 2018. The dynamic roles of TGF-ß signalling in EBV-associated cancers. Cancers, 10 (8)
- Leonard, Sarah M., Pereira, Merlin, Roberts, Sally, Cuschieri, Kate, Nuovo, Gerard, Athavale, Ramanand, Young, Lawrence, Ganesan, Raji, Woodman, Ciarán B., 2016. Evidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women. Scientific Reports, 6
- Young, Lawrence S., Yap, Lee Fah, Murray, Paul G., 2016. Epstein?Barr virus : more than 50 years old and still providing surprises. Nature Reviews Cancer, 16 (12), pp. 789-802
- Morris, Mhairi A., Dawson, Christopher W., Laverick, Louise, Davis, Alexandra M., Dudman, Joe P. R., Raveenthiraraj, Sathuwarman, Ahmad, Zeeshan, Yap, Lee-Fah, Young, Lawrence S., 2016. The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFß and ß1 integrin signalling. Scientific Reports, 6
- Palser, Anne L., Grayson, Nicholas E., White, Robert E., Corton, Craig, Correia, Samantha, Ba abdullah, Mohammed M., Watson, Simon J., Cotten, Matthew, Arrand, John R., Murray, Paul G., Allday, Martin J., Rickinson, Alan B., Young, Lawrence S., Farrell, Paul J., Kellam, Paul, 2015. Genome diversity of Epstein-Barr virus from multiple tumor types and normal infection. Journal of Virology, 89 (10), pp. 5222-5237
- Young, Lawrence S., 2015. Pathogens best paper awards for 2015. Pathogens, 4 (2), pp. 387-389
- Lo, Angela Kwok-Fung, Dawson, Christopher W., Young, Lawrence S., Ko, Chuen-Wai, Hau, Pok-Man, Lo, Kwok-Wai, 2015. Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells. The Journal of Pathology, 237 (2), pp. 238-248
- Elmetwali, Taha, Young, Lawrence S., Palmer, Daniel H., 2014. Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-?B activation via a negative feedback loop. Cell Death and Disease, 5 (5)
- Hu, Chunfang, Wei, Wenbin, Chen, Xiaoyi, Woodman, Ciaran B. J., Yao, Yunhong, Nicholls, J. M. (John M.), Joab, Irène, Sihota, Sim K., Shao, Jian-Yong, Derkaoui, K. Dalia, Amari, Aicha, Maloney, Stephanie L., Bell, Andrew I., Murray, Paul G., Dawson, Christopher W., Young, Lawrence S., Arrand, J. R. (John R.), 2012. A global view of the oncogenic landscape in nasopharyngeal carcinoma : an integrated analysis at the genetic and expression levels. PLoS One, Vol.7 (No.7)
- Sivachandran, N., Dawson, C. W., Young, Lawrence S., Liu, F.-F., Middeldorp, J., Frappier, L., 2012. Contributions of the Epstein-Barr virus EBNA1 protein to gastric carcinoma. Journal of Virology, Vol.86 (No.1), pp. 60-68
- Leonard, S. M., Wei, W., Collins, S. I., Pereira, M., Diyaf, A., Constandinou-Williams, C., Young, Lawrence S., Roberts, S., Woodman, Ciaran B. J., 2012. Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women. Carcinogenesis, Vol.33 (No.7), pp. 1286-1293
- Dawson, Christopher W., Port, Rebecca J., Young, Lawrence S., 2012. The role of the EBV-encoded latent membrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC). Seminars in Cancer Biology, Vol.22 (No.2), pp. 144-153
- Ma, Y. T., Collins, S. I., Young, Lawrence S., Murray, Paul G., Woodman, Ciaran B. J., 2011. Smoking initiation is followed by the early acquisition of epigenetic change in cervical epithelium: a longitudinal study. British Journal of Cancer, Vol.104 (No.9), pp. 1500-1504
- Steele, J. C., Rao, A., Marsden, J. R., Armstrong, C. J., Berhane, S., Billingham, L. J., Graham, N., Roberts, C., Ryan, G., Uppal, H., Walker, C., Young, Lawrence S., Steven, N. M., 2011. Phase I/II trial of a dendritic cell vaccine transfected with DNA encoding melan A and gp100 for patients with metastatic melanoma. Gene Therapy, Vol.18 (No.6), pp. 584-593
- Cader, Fathima Zumla, Kearns, Pamela, Young, Lawrence S., Murray, Paul, Vockerodt, Martina, 2010. The contribution of the Epstein-Barr virus to the pathogenesis of childhood lymphomas. Cancer Treatment Reviews, Vol.36 (No.4), pp. 348-353
- Valentine, Robert, Dawson, Christopher W., Hu, Chunfang, Shah, Khilan M., Owen, Thomas J., Date, Kathryn L., Maia, Sonia P., Shao, Jianyong, Arrand, J. R. (John R.), Young, Lawrence S., O'Neil, John D., 2010. Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-?B pathway in carcinoma cells by inhibiting IKK phosphorylation. Molecular Cancer, Vol.9 (No.1)
- Lo, Angela K. F., Dawson, Christopher W., Lo, Kwok W., Yu, Yanxing, Young, Lawrence S., 2010. Upregulation of Id1 by Epstein-Barr Virus-encoded LMP1 confers resistance to TGFß-mediated growth inhibition. Molecular Cancer, Vol.9 (No.1)
- Collins, Stuart, Rollason, Terry P., Young, Lawrence S., Woodman, Ciaran B. J., 2010. Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women : a longitudinal study. European Journal of Cancer Care, Vol.46 (No.2), pp. 405-411
- Elmetwali, Taha, Searle, Peter F., McNeish, Iain, Young, Lawrence S., Palmer, Daniel H., 2010. CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus. Molecular Cancer, Vol.9 (No.1)
- Elmetwali, Taha, Young, Lawrence S., Palmer, Daniel H., 2010. CD40 ligand-induced carcinoma cell death : a balance between activation of TNFR-associated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals. Journal of Immunology, Vol.184 (No.2), pp. 1111-1120
- Constandinou-Williams, C., Collins, S. I., Roberts, S., Young, Lawrence S., Woodman, Ciaran B. J., Murray, Paul G., 2010. Is human papillomavirus viral load a clinically useful predictive marker? A longitudinal study. Cancer Epidemiology Biomarkers & Prevention, Vol.19 (No.3), pp. 832-837
- Owen, Thomas J., O'Neil, John D., Dawson, Christopher W., Hu, Chunfang, Chen, Xiaoyi, Yao, Yunhong, Wood, Victoria H. J., Mitchell, Louise E., White, Robert J., Young, Lawrence S., Arrand, J. R., 2010. Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors. Molecular Cancer, Vol.9 (No.1)
- Shah, K. M., Young, Lawrence S., 2009. Epstein-Barr virus and carcinogenesis : beyond Burkitt's lymphoma. Clinical Microbiology and Infection, Vol.15 (No.11), pp. 982-988
- Bose, Shikha, Yap, Lee-Fah, Fung, Matthew, Starzcynski, Jane, Saleh, Amyza, Morgan, Susan, Dawson, Christopher W., Chukwuma, Marilyn B., Maina, Esther, Buettner, Maike, Wei, Wenbin, Arrand, J. R. (John R.), Lim, Paul V. H., Young, Lawrence S., Teo, Soo Hwang, Stankovic, Tatjana, Woodman, Ciaran B. J., Murray, Paul G., 2009. The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. Journal of Pathology, Vol.217 (No.3), pp. 345-352
- Collins, S. I., Constandinou-Williams, C., Wen, K., Young, Lawrence S., Roberts, S., Murray, Paul G., Woodman, Ciaran B. J., 2009. Disruption of the E2 Gene is a common and early event in the natural history of cervical human papillomavirus infection : a longitudinal cohort study. Cancer Research, Vol.69 (No.9), pp. 3828-3832
- Palmer, Daniel H., Midgley, Rachel S., Mirza, Noweeda, Torr, Elizabeth E., Ahmed, Forhad, Steele, Jane C., Steven, Neil M., Kerr, David J., Young, Lawrence S., Adams, David H., 2009. A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma. Hepatology, Vol.49 (No.1), pp. 124-132
- Schreck, Sabine, Friebel, Daniela, Buettner, Maike, Distel, Luitpold, Grabenbauer, Gerhard, Young, Lawrence S., Niedobitek, Gerald, 2009. Prognostic impact of tumour-infiltrating Th2 and regulatory T cells in classical Hodgkin lymphoma. Hematological Oncology, Vol.27 (No.1), pp. 31-39
- Patel, Prashant, Young, J Graham, Mautner, Vivien, Ashdown, Daniel, Bonney, Sarah, Pineda, Robert G., Collins, Stuart I., Searle, Peter F., Hull, Diana, Peers, Elizabeth, Chester, John, Wallace, D. Michael, Doherty, Alan, Leung, Hing, Young, Lawrence S., James, Nicholas D., 2009. A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1984. Molecular Therapy, Vol.17 (No.7), pp. 1292-1299
- Morris, Mhairi A., Dawson, Christopher W., Young, Lawrence S., 2009. Role of the Epstein?Barr virus-encoded latent membrane protein-1, LMP1, in the pathogenesis of nasopharyngeal carcinoma. Future Oncology, Vol.5 (No.6), pp. 811-825
- Shah, K. M., Stewart, S. E., Wei, W., Woodman, Ciaran B. J., O'Neil, J. D., Dawson, Christopher W., Young, Lawrence S., 2009. The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation. Oncogene, Vol.28 (No.44), pp. 3903-3914
- Baumforth, Karl R. N., Birgersdotter, Anna, Reynolds, Gary M., Wei, Wenbin, Kapatai, Georgia, Flavell, Joanne R., Kalk, Emma, Piper, Karen, Lee, Steve, Machado, Lee, Hadley, Kerry, Sundblad, Anne, Sjoberg, Jan, Bjorkholm, Magnus, Porwit, Anna A., Yap, Lee-Fah, Teo, Soohwang, Grundy, Richard G., Young, Lawrence S., Ernberg, Ingemar et al (Select to open full list), 2008. Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin's Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells. American Journal of Pathology, Vol.173 (No.1), pp. 195-204
- Flavell, Joanne R., Baumforth, Karl R. N., Wood, Victoria H. J., Davies, Gillian L., Wei, Wenbin, Reynolds, Gary M., Morgan, Susan, Boyce, Andrew, Kelly, Gemma L., Young, Lawrence S., Murray, Paul G., 2008. Down-regulation of the TGF-beta target gene, PTPRK, by the Epstein-Barr virus encoded EBNA1 contributes to the growth and survival of Hodgkin lymphoma cells. Blood, Vol.111 (No.1), pp. 292-301
- Young, J. G., Green, N. K., Mautner, V., Searle, P. F., Young, Lawrence S., James, Nicholas D., 2008. Combining gene and immunotherapy for prostate cancer. Prostate Cancer and Prostatic Diseases, Vol.11 (No.2), pp. 187-193
- Morris, M., Young, Lawrence S., Dawson, Christopher W., 2008. DNA tumour viruses promote tumour cell invasion and metastasis by deregulating the normal processes of cell adhesion and motility. European Journal of Cell Biology, Vol.87 (No.8-9), pp. 677-697
- Dawson, Christopher W., Laverick, L., Morris, M. A., Tramoutanis, G., Young, Lawrence S., 2008. Epstein-Barr virus-encoded LMP1 regulates epithelial cell motility and invasion via the ERK-MAPK pathway. Journal of Virology, Vol.82 (No.7), pp. 3654-3664
- Morris, M. A., Dawson, C. W., Wei, W., O'Neil, J. D., Stewart, S. E., Jia, J., Bell, A. I., Young, Lawrence S., Arrand, J. R. (John R.), 2008. Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes. Journal of General Virology, Vol.89 (No.11), pp. 2806-2820
- O'Neil, J. D., Owen, T. J., Wood, V. H. J., Date, K. L., Valentine, R., Chukwuma, M. B., Arrand, J. R. (John R.), Dawson, C. W., Young, Lawrence S., 2008. Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro. Journal of General Virology, Vol.89 (No.11), pp. 2833-2842
- Vockerodt, M., Morgan, S. L., Kuo, M., Wei, W., Chukwuma, M. B., Arrand, J. R. (John R.), Kube, D., Gordon, J., Young, Lawrence S., Woodman, Ciaran B. J., Murray, Paul G., 2008. The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype. Journal of Pathology, Vol.216 (No.1), pp. 83-92
- Herod, J. J., Eliopoulos, A. G., Warwick, Jane, Niedobitek, G., Young, Lawrence S., Kerr, D. J., 1996. The prognostic significance of Bcl-2 and p53 expression in ovarian carcinoma. Cancer Research, 56 (9), pp. 2178-84
- Grammatopoulos, Dimitris K., Li, Weizi, Young, Lawrence S., Anderson, Neil R., 2023. UK diagnostics in the era of ?permacrisis? : is it fit for purpose and able to respond to the challenges ahead?. Clinical Chemistry and Laboratory Medicine (CCLM), De Gruyter, pp. e225-e226
- Stewart, Stuart, Newson, Louise, Briggs, Tracy A., Grammatopoulos, Dimitris, Young, Lawrence S., Gill, Paramjit, Stewart, Stuart, Newson, Louise, Briggs, Tracy A., Grammatopoulos, Dimitris, Young, Lawrence S., Gill, Paramjit, Stewart, Stuart, Newson, Louise, Briggs, Tracy A., Grammatopoulos, Dimitris, Young, Lawrence S., Gill, Paramjit, 2021. Long COVID risk - a signal to address sex hormones and women's health. The Lancet Regional Health - Europe, Elsevier BV
- Stewart, Stuart, Newson, Louise, Briggs, Tracy A., Grammatopoulos, Dimitris, Young, Lawrence S., Gill, Paramjit, 2021. Long COVID risk - a signal to address sex hormones and women's health. The Lancet Regional Health - Europe, Elsevier BV
- Stewart, Stuart, Newson, Louise, Briggs, Tracy A., Grammatopoulos, Dimitris, Young, Lawrence S., Gill, Paramjit, Stewart, Stuart, Newson, Louise, Briggs, Tracy A., Grammatopoulos, Dimitris, Young, Lawrence S., Gill, Paramjit, Stewart, Stuart, Newson, Louise, Briggs, Tracy A., Grammatopoulos, Dimitris, Young, Lawrence S., Gill, Paramjit, 2021. Long COVID risk - a signal to address sex hormones and women's health. The Lancet Regional Health - Europe, Elsevier BV
- Dyer, Nigel, Young, Lawrence S., Ott, Sascha, 2016. Artifacts in the data of Hu et al.. Nature Genetics, Nature Publishing Group, pp. 2-3
| Title | Funder | Award start | Award end |
|---|---|---|---|
| HistoMap: Stain agnostic feature representations to identify clinically relevant traits in the tumour microenvironment | MRC | 03 May 2023 | 02 May 2026 |
| Visiting worker Agreement - A Low | Hong Kong Baptist University | 01 Oct 2020 | 30 Sep 2023 |
| Development of a SARS-CoV-2 spike protein binding assay using human epithelial cells for COVID-19 therapy discovery and development | Innovate UK | 01 Jan 2021 | 30 Jun 2022 |
| WMHTC Strategic Partnership Agreement | West Midlands Health Technologies Cluster Limited | 01 Jul 2021 | 31 Mar 2022 |
| Tthe effect the shortening of career appointments is having on practice as perceived by practitioners and students | Higher Education Careers Services Unit | 01 Sep 2016 | 31 Aug 2017 |
| Enhancing the Employment Success of UK-educated Chinese Students | British Council (China) | 01 Jan 2016 | 30 Sep 2016 |
| LMP2 targeting peptide in molecular diagnosis and target therapy of EBV+ cancer | Royal Society | 01 Apr 2014 | 30 Sep 2016 |