The pharmaceutical industry is constantly evolving. The development of safe and effective drugs relies on advanced analytical techniques that enable precise characterisation and quality control of compounds. Advanced techniques such as spectroscopy, nuclear magnetic resonance and X-ray and electron diffraction are crucial for understanding the molecular structure, purity and stability of pharmaceutical substances to ensure they function as intended.

Warwick works at the forefront of innovation in drug developments, using an array of advanced techniques to address challenges in modern medicine and improve therapeutic outcomes.

Challenges in industry

Pharmaceutical manufacturers need to apply analytical techniques throughout the drug development and production process, from assessing the chemical properties of compounds in preclinical research to monitoring a drug’s stability and performance over time.

Polymer synthesis techniques are key in developing drug delivery systems and other pharmaceutical applications. They allow for the precise creation of polymers with unique and tailored properties, essential for controlled drug release and enhancing the bioavailability of active ingredients. Polymer characterisation techniques such as thermal analysis, rheology and chromatography provide crucial information on polymer behaviour, composition and purity.

X-ray diffraction provides insights into the crystalline structure of drug compounds and produces crystal diagrams that are vital for understanding their stability and solubility – key factors in drug efficacy. Electron diffraction offers much the same information but can be performed on individual crystallites from powder, enabling structural analysis where X-ray-suitable crystals can’t be grown.

Solid-state NMR is another essential tool, offering detailed information on molecular dynamics and structural properties. This technique is particularly useful for studying drug formulations, including polymorphs and amorphous forms, which can significantly affect a drug's performance.

Spectroscopy techniques, such as Raman and Fourier-Transform Infrared (FTIR) spectroscopy, enable detailed analysis of molecular interactions and chemical bonds within pharmaceutical compounds. This information is key for understanding drug mechanisms, optimising formulations, and ensuring product consistency.

In addition, antimicrobial testing is vital for gauging the effectiveness of pharmaceutical products against harmful microorganisms, which is key for developing antibiotics and other antimicrobial agents that are safe for human use. One common test involves determining the minimum inhibitory concentration (MIC) - the lowest concentration of the drug that prevents growth of the microorganism. This is vital for establishing dosage and efficacy guidelines.

Work with Warwick to help you drive innovation

The University of Warwick’s Research Technology Platforms (RTPs) and other facilities are available to external clients to support pharmaceutical research and innovation. Our state-of-the-art equipment and expert support enables companies to address complex challenges in drug development and antimicrobial research.

Polymer Synthesis and Characterisation RTP: Warwick is globally recognised as a centre of excellence for polymer research. Our world-class Polymer Facility is equipped with a wide range of state-of-the-art equipment for evaluating the properties of polymers in pharmaceuticals, as well as offering bespoke polymer synthesis.

UK High-Field Solid-State NMR Facility: Warwick is home to some of the most powerful NMR spectrometers globally, including a new 1.2 GHz system. This facility offers unparalleled insights into the molecular structure of pharmaceutical compounds.

Spectroscopy RTP: This facility features a range of Raman and FTIR spectrometers that can assess the chemical composition and stability of pharmaceuticals, with capabilities for variable temperature and time-resolved spectroscopy.

X-ray diffraction (XRD) RTP: Our XRD facility is equipped with advanced diffraction systems, now including our dedicated electron diffractometer, that provide critical data on the crystalline structure of pharmaceutical compounds. Our leading experts in crystallography provide precise and reliable analysis for pharmaceutical research.

Antimicrobial Screening (AMR) Facility: Our AMR facility offers high-throughput screening services crucial for discovering new antimicrobial agents. Equipped with automated liquid handling systems, the facility enables rapid and reliable testing of drug candidates, supported by experts in microbiology and antimicrobial resistance.

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Contact Us

Get in touch to discuss how we can help solve your challenges. Contact Claire Gerard, Warwick Scientific Services Manager: . We look forward to collaborating with you.