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Chemistry Peter J. Sadler Group

Publications


 

2016
 


 

A Novel Dual-Functioning Ruthenium(II)-Arene Complex of an Anti-microbial Ciprofloxacin Derivative - Anti-proliferative and Anti-microbial Activity.

Z. Ude, I. Romero-Canelón, B. Twamley, D. F. Hughes, P. J. Sadler and C. J. Marmion.
J. Inorg. Biochem., 2016, accepted manuscript
   
 

Hydrosulfide adducts of organo-iridium anticancer complexes.

P. Štarha, A. Habtemariam, I. Romero-Canelón, G. Clarkson, and P. J. Sadler. Inorg Chem., 2016, in press
   


2015
 

 

Half-sandwich rhodium(III) transfer hydrogenation catalysts: reduction of NAD+ and pyruvate, and antiproliferative activity

J. J. Soldevila-Barreda, A. Habtemariam, I. Romero-Canelón and P. J. Sadler
J. Inorg. Biochem., 2015, DOI: 10.1016/j.jinorbio.2015.10.008
Available via Open Access
   

Enhancement of selectivity of an organometallic anticancer agent by redox modulation.

I. Romero-Canelón, M. Moss and P. J. Sadler.
J. Med. Chem. 2015, DOI: 10.1021 /acs.jmedchem.5b00655.
Available via Open Access
 



Potent organo-osmium complex shifts metabolism in epithelial ovarian cancer cells.

J. M. Hearn, I. Romero-Canelón, A. F. Munro, Y. Fu, A. M. Pizarro, M. J. Garnett, U. McDermott, N. O. Carragher and P. J. Sadler.
PNAS, 2015, 112, E3800-3805.
   
 

Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT).

I. Romero-Canelón, B. Phoenix, A. Pitto-Barry, J. Tran, J. J. Soldevila-Barreda, N. Kirby, S. Green, P. J. Sadler, N. P. E. Barry.
J. Organomet.Chem. 2015, DOI: 10.1016/j.jorganchem.2015.05.011
Available via Open Access
   
 

Systems approach to metal-based pharmacology.

I. Romero-Canelón and P.J. Sadler.
PNAS. 2015,112, 4187-4188.
   
 

Contrasting Anticancer Activity of Half-Sandwich Iridium(III) Complexes Bearing Functionally Diverse 2-Phenylpyridine Ligands.

A.J. Millett, A. Habtemariam, I. Romero-Canelón, G. J. Clarkson and P. J. Sadler.
Organometallics, 2015, 34, 2683-2694.
Available via Open Access
   
 

A new approach to anticancer drug design: transfer hydrogenation catalysis in cells.

I. Romero-Canelón,¥ J. J. Soldevila-Barreda,¥ A. Habtemariam, and P. J. Sadler.
Nature Communications, 2015, 6:6582 (¥ Both authors contributed equally to the manuscript)
Available via Open Access
   
 

2014
   

Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells.

S. H. van Rijt, I. Romero-Canelón, Y. Fu, S. D. Shnyder and P. J. Sadler.
Metallomics, 2014, 6, 1014-1022
Selected as HOT PAPER
Available via Open Access
   
 

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts.

Z. Liu, I. Romero-Canelón; B. Qamar, J.M.Hearn, A. Habtemariam, N.P.E. Barry, A.M. Pizarro, G.J. Clarkson, P.J. Sadler.
Angew. Chem., Int. Ed. 2014, 53, 3941-3946.
Selected as VIP
Available via Open Access
   
 

Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity.

N. P.E. Barry, A. Pitto-Barry, I. Romero-Canelón, J. Tran, J. J. Soldevila-Barreda, I. Hands-Portman, C. J. Smith, N. Kirby, A. P. Dove, R. K. O’Reilly, and P. J. Sadler.
Faraday Discussions, 2014, 175, 229-240.
Available via Open Access
   
 

Unexpected Crosslinking and Diglycation as Advanced Glycation End-Products from Glyoxal.

A. F. Lopez-Clavijo, C. A. Duque-Daza, A. Soulby, I. Romero Canelón, M. P. Barrow, P. B. O'Connor.
J. Am. Soc. Mass Spectrom., 2014, 25, 2125-2133.
   
 

Potent Half-Sandwich Iridium(III) Anticancer Complexes Containing C^N-Chelated and Pyridine Ligands.

Z. Liu, I. Romero-Canelón, A. Habtemariam, G.J. Clarkson, and P. J. Sadler.
Organometallics, 2014, 33, 5324-5333
Available via Open Access
   
 

Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells.

J. O. Suberu, I. Romero-Canelón, N. Sullivan, A. A. Lapkin and G. C. Barker,
ChemMedChem, 2014, 9, 2791-2797.
Available via Open Access
   
 

Study of an Unusual Advanced Glycation End-Product (AGE) Derived from Glyoxal Using Mass Spectrometry.

A. F. Lopez-Clavijo, C. A. Duque-Daza, I. Romero-Canelón, M. P. Barrow, D. Kilgour, N. Rabbani, P. J. Thornalley, P. B. O'Connor.
J. Am. Soc. Mass Spectrom., 2014, 25, 673-683
   
 

2013
   

Next generation metal anticancer complexes: Multi-targeting via redox modulation.

I. Romero-Canelón and P.J. Sadler.
Inorg. Chem., 2013, 52, 12276-12291.
Selected for front cover
   
 

Organometallic Iridium(III) Anticancer Complexes with New Mechanisms of Action: NCI-60 Screening, Mitochondrial Targeting, and Apoptosis.

J.M. Hearn, I. Romero-Canelón, B. Qamar, Z. Liu, I. Hands-Portman and P.J. Sadler,
ACS Chemical Biology, 2013, 8, 1335-1343
Available via Open Access
   
 

The Contrasting Activity of Iodido versus Chlorido Ruthenium and Osmium Arene Azo- and Imino-pyridine Anticancer Complexes: Control of Cell Selectivity, Cross-Resistance, p53 Dependence, and Apoptosis Pathway.

I. Romero-Canelón, L. Salassa and P.J. Sadler.
J.Med.Chem, 2013, 56, 1291-1300
   
 

2012
   

Contrasting cellular uptake pathways for ruthenium arene anticancer complexes.

I. Romero-Canelón, A. M. Pizarro, A. Habtemariam and P. J. Sadler.
Metallomics, 2012, 4,1271-1279.
Available via Open Access
   
 

2006-2010
   
2010

Synthesis, spectroscopic and electrochemical characterization of nickel(II) and cobalt(II) complexes with new N2S2 ligands, ethyl- and bencyl-N,N'-alkyl-bis(2–amino–1–cyclopentencarbodithioate).

R. R. Contreras, J.N. Aranguren, F. Bellandi, A. Gutiérrez, I. Romero, G. Colt Vela.
Ciencia & Ingeniería, 2010, 31, 3, 159-168
   
2008

Hydroformylation reactions of the trans-Mo(CO)4(p-C5NH4SO3Na)2 complex in biphasic medium.

T. Suárez, B. Fontal, G. Zambrano, M. Reyes, F. Bellandi, R. Contreras, J. C. Díaz, P. Cancines, Y. Fonseca, I. Romero.
Reacion Kinetics and Catalysis Letters, 2008, 94, 1, 27-34.
   
 

Synthesis and characterization of trans-Mo(CO)4(p-C5NH4SO3Na)2.

T. Suárez, B. Fontal, G. Zambrano, M. Reyes, F. Bellandi, R. Contreras, J. C. Díaz, P. Cancines, Y. Fonseca, I. Romero.
Reacion Kinetics and Catalysis Letters, 2008, 94, 1, 21-26
   
 

Olefin hydroformylation catalysis with RuCl2(DMSO)4.

M. Reyes, F. Bellandi, E. Parra, Y. Fonseca, B. Fontal, T. Suárez, R. Contreras, I. Romero, L. Prado, P. Cancines.
Avances en Quimica, 2008, 3, 1, 15-20.
   
2007

Hydroformilation of naphtas with rhodium complex in biphasic médium.

M. Reyes, D. Mercades, B. Fontal, T. Suárez, F. Bellandi, R. Contreras, I. Romero, Y. Fonseca, P. Cancines.
Reaction Kinetic Catalysis Letters, 2007, 90, 2, 347-354.
   
2006

Nueva estrategia de síntesis del 2-amino-1-ciclopentendicarboditioato de propilo y de los proligandos derivados del tipo [N2S2]2-.

R.R. Contreras, B. Fontal, A. Bahsas, M. Reyes, F. Bellandi, T. Suárez, I. Romero, A. Contreras, P. Cancines.
Avances en Química. 2006, 1, 9-14.
   
 

Intramolecular hydrogen bonding in dibenzyl 2,2´-(propane-1,3-iyldiimino)bis(cyclopent-1-ene-1-carbodithioate).

R. R. Contreras, B. Fontal, I. Romero, R. Atencio y A. Briceño.
Acta Crystallographica, Section E, 2006, 62, 205 – 208.
   
   









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I. Romero-Canelón