The project is to develop and apply innovative modelling techniques to tackle problems at the forefront of pharmacological research permitting step-change advancements in drug development, supporting the EU policy on healthcare and pharmaceutical development as well as underpinning the EU's Innovative Medicines Initiative.
This is performed through the formation of an interdisciplinary collaborative partnership between AstraZeneca (AZ) and the University of Warwick (UoW) to train Early Stage Researchers (ESRs) in systems modelling tools and techniques enabling them to perform ground-breaking research in the emerging field of Quantitative and Systems Pharmacology (QSP), placing Europe as leaders in this field.
The project objectives are achieved through four research work packages (organised into five separate projects) that include innovative training and research of relevance to the pharmaceutical industry worldwide. The work is being undertaken by five ESR's co-supervised by academics from the UoW (Dr. Mike Chappell and Dr. Neil Evans), staff from AZ and associated partners.
Work Package 1: Modelling Dose - Response time outcome relationships (projects 1 & 2).
Work Package 2: Modelling tissue (lung) target exposure (project 3).
Work Package 3: Modelling Cardiovascular Safety - Target Engagement - Exposure (project 4).
Work Package 4: Deconvolution in non-linear ordinary differential equations for Quantitative and Systems Pharmacology (project 5).