13:00 - 14:00,
Weds 10 April, 2024

C5.21

Prof Batey joins as an invited guest speaker.

This is a departmental lecture for all students and staff. Please come along. Tea, coffee and refreshments will be provided from 12:30.

"Natural Product Inspired Synthetic Methods Development: Macrocycle and Heterocycle Formation"

Biologically active natural products including alkaloids, terpenoids, macrocyclic peptides and depsipeptides serve as an inspiration for the synthetic chemist. Their often complex and diverse structures can pose interesting synthetic challenges that serve as inspiration for the development of new synthetic methods. They can also act as potential lead structures for the development of pharmaceuticals or biological probe molecules, including anticancer, antibiotic, antiviral, antifungal, anti-inflammatory, and CNS activities. Targets of particular interest to our research group include natural products involved in cellular protein degradation pathways such as the ADEPs (ClpP activation), the syringolins (proteasome inhibition), and himeic acid A (E1 ligase inhibition). Progress toward their synthesis and the development of synthetic methods for macrocyclization, heterocycle formation, and various functionalization strategies will be described.