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Department of Chemistry

Prof. Peter O'Connor

Professor of Analytical Chemistry

Peter_Oconnor.jpgImproving the performance and applications of Fourier Transform Ion Cyclotron Resonance (FTICR) mass spectrometers. We work collaboratively with other research groups to demonstrate the effectiveness of higher specification FTICR mass spectrometry in specific applications. A particular focus in recent years has been on fundamental studies of the mechanism of electron capture dissociation, FTICR instrument design, post-translational modification analysis of proteins and peptides, deamidation and isomerization of aspartic acid residues in peptides and proteins, etc.

p dot oconnor at warwick dot ac dot uk

02476 1 51008

Office G01, Milburn house

Peter O'Connor Group

Groups at Warwick

I am working on the following projects at the moment:

  • Project number 1
  • Project number 2
  • Project number 3

I am currently interested in improving the performance and applications of Fourier Transform Ion Cyclotron Resonance (FTICR) mass spectrometers; fundamental studies of the mechanism of electron capture dissociation; FTICR instrument design; post-translational modification analysis of proteins and peptides; and deamidation and isomerization of aspartic acid residues in peptides and proteins.

Peter teaches the.......

I am supervising the following PhD students:

  • Person 1, Topic 1
  • Person 2, Topic 2
  • Person 3, Topic 3

At the moment I am unable to accept any further applications, but if you get in touch I'll see if a member of my team might be able to help.

  • 1. Wei, J.; Antzutkin, O. N.; Filippov, A. V.; Iuga, D.; Lam, P. Y.; Barrow, M. P.; Dupree, R.; Brown, S. P.; O'Connor, P. B., Amyloid Hydrogen Bonding Polymorphism Evaluated by 15N{17O}REAPDOR Solid-State NMR and Ultra-High Resolution FTICR-MS. Biochemistry 2016, 55 (14), 2065-2068.

    2. Simon, H. J.; van Agthoven, M. A.; Lam, P. Y.; Floris, F.; Chiron, L.; Delsuc, M. A.; Rolando, C.; Barrow, M. P.; O'Connor, P. B., Uncoiling collagen: a multidimensional mass spectrometry study. Analyst 2016, 141 (1), 157-165.

    3. Agthoven, M. A. v.; Chiron, L.; Coutouly, M.-A.; Wootton, C. A.; Soulby, A.; Wei, J.; Barrow, M. P.; Delsuc, M.-A.; Rolando, C.; O'Connor, P. B., Two-Dimensional Mass Spectrometry for Proteomics, a Comparative Study with Cytochrome c. Anal Chem 2016, 88 (8), 4409-4417.

    4. Wootton, C. A.; Sanchez-Cano, C.; Liu, H.-K.; Barrow, M. P.; Sadler, P. J.; O'Connor, P. B., Binding of an organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top-Down FT-ICR mass spectrometry. Dalton Transactions 2015, 44 (8), 3624-3632.

    5. Soulby, A. J.; Heal, J. W.; Barrow, M. P.; Roemer, R. A.; O'Connor, P. B., Does deamidation cause protein unfolding? A top-down tandem mass spectrometry study. Protein Science 2015, 24 (5), 850-860