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Papers 2005

Sadler Group Papers 2005


Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA-binding proteins and repair. Relationship to cytotoxicity
O. Novakova, J. Kasparkova, V. Bursova, C. Hofr, M. Vojtiskova, H. Chen, P.J. Sadler and V. Brabec

Chem. Biol. 2005, 12, 121-129.

Role of tyrosine-84 in controlling the reactivity of cysteine-34 of human albumin
A.J. Stewart, C.A. Blindauer, S. Berezenko, D. Sleep, D. Tooth and P.J. Sadler

FEBS J. 2005, 272, 353-362.

Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organo-metallic agent, RM175
R. Hayward, Q. Schornagel, R. Tente, J. Macpherson, R. Aird, S. Guichard, A. Habtemariam, P.J. Sadler and D.I. Jodrell

Cancer Chemother. Pharmacol., 2005, 55, 577-583.

Protein recognition of macrocycles: binding of anti-HIV metallocyclams to lysozyme.
T.M. Hunter, I.W. McNae, X. Liang, J. Bella, S. Parsons, M.D. Walkinshaw, and P.J. Sadler

Proc. Natl. Acad. Sci. USA, 2005, 102, 2288-2292.

How to hide zinc in a small protein
C.A. Blindauer and P.J. Sadler

Acc. Chem. Res. 2005, 38, 62-69.

Two-photon-induced photoisomerization of an azo dye.
F.W. Magennis, F.S. Mackay, A.C. Jones, K.M. Tait and P.J. Sadler

Chem. Mater. 2005, 17, 2059-2062.

Competitive reactions of a ruthenium arene anticancer complex with histidine, cytochrome c and an oligonucleotide
F. Wang, J. Bella, J.A. Parkinson and P.J.Sadler

J. Biol. Inorg. Chem. 2005, 10, 147-155.

Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2
S.J. Roberts; A.J Stewart, R. Schmid, C.A Blindauer, S.R Bond, P.J Sadler, C. Farquharson

Biochim. Biophys. Acta 2005, 1752, 73-82.

G-G Base-pairing in nucleotide adducts of the anticancer drug cis-[PtCl2(NH3)(2-picoline)] and its trans isomer
G. McGowan, S. Parsons and P.J. Sadler

Chem. Eur. J. 2005, 11, 4396-4404.

The contrasting chemistry of cis and trans PtII diamine anticancer compounds: hydrolysis studies of picoline complexes
G. McGowan, S. Parsons and P.J. Sadler

Inorg. Chem. 2005, 44, 7459-7467.

Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes
Y.-K. Yan, M. Melchart, A. Habtemariam and P.J. Sadler

Chem. Commun. 2005, 4764 – 4776.

Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex : detection of a sulfenato intermediate
F. Wang, J. Xu, A. Habtemariam, J. Bella and P.J Sadler

J. Amer. Chem. Soc. 2005, 127, 17734-17743.

Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity
F. Wang, A. Habtemariam, E.P.L. van der Geer, R. Fernández, M. Melchart, R.J. Deeth, R. Aird, S. Guichard, F.P.A. Fabbiani, P. Lozano-Casal, I.D.H. Oswald, D.I. Jodrell, S. Parsons, P.J. Sadler¶

Proc. Natl. Acad. Sci. USA, 2005, 102, 18269-18274.