Warwick Medical School authors, Dr Helen Atherton, Dr Jo Parsons and Dr Carol Bryce looked at the rate of missed GP appointments in the UK. Their findings are published in the BJGP and Jo Parsons is also interviewed in a podcast discussing some of the findings and implications of this work.
Missed general practice appointments have considerable time and cost implications for the NHS, and leaves patients with unmet health needs, and potentially delayed diagnoses or medical treatment. This systematic review, entitled ‘Which patients miss appointments with general practice and the reasons why’ updated work conducted in 2003, and aimed to examine the rate of missed booked appointments, which patients are more likely to miss appointments, and some reasons for this. Findings of this review has potential implications for practices in targeting interventions to patients that are at increased likelihood of missing appointments, and in attempting to overcome common reasons that appointments are missed.
More information can be found on the GP Online webpages here.
T cells discriminate between healthy and infected cells with remarkable sensitivity when mounting an immune response, which is hypothesized to depend on T cells combining stimuli from multiple antigen‐presenting cell interactions into a more potent response. To quantify the capacity for T cells to accomplish this, we have developed an antigen receptor that is optically tunable within cell conjugates, providing control over the duration, and intensity of intracellular T‐cell signalling.
Ethnicity-specific BMI cutoffs for obesity based on type 2 diabetes risk in England: a population-based cohort study
Researchers from four leading institutions (University of Warwick, Oxford University, The London School of Hygiene & Tropical Medicine and the UCL Institute of Health Informatics) came together in partnership with the Ethnic Health Forum to create this population-based cohort study using linked primary care and secondary care electronic records from England.
This study’s findings come at a critical time, given the increased focus on health inequalities affecting millions of people from minority ethnic communities as well as the link between obesity and COVID-19 (a condition also adversely affecting UK BAME people).
Read the press release here
Read the article here
Unravelling the role of proline in cryopreserving cell monolayers
The cryopreservation of cells as adherent monolayers is very challenging, compared to in suspension The GibsonGroup's latest work explores the role of proline in ‘preparing’ cells for cryopreservation, observing they slow growth rates, and enable more cells to recover from cryopreservation compared to without proline. Read the paper here
Small ice binding peptides from phage display
The GibsonGroup have collaborated with Prof Harm Anton Klok at EPFL, and the Sosso Lab at Warwick to discover new, small, ice binding peptides. The team used phage display to screen billions of possible sequences, to identify a 14 amino acid cyclic peptide than can bind ice crystals. The peptide was a potent ice growth inhibitor and the use of the as a ‘CryoTag’ to purify proteins via ice-binding was demonstrated. This will help develop new cryoprotectants and an understand of how proteins can recognise ice, in a large excess of water.
Biomimetic Polymer Particles to Control Ice Growth
The GibsonGroup have reported a surprising result that larger (several hundred nanometres) polymer nanoparticles can stop ice recrystallisation, and in some cases bind to the ice - a feature commonly associated with ice binding proteins from extremophiles. The team used a technique termed polymerization-induced self-assembly to produce the particles, which is appealing as they can be made at scale and are highly tunable, compared to producing proteins. These materials will be explored as part of the team's cryobiology research.
Unwrapping a cellular mystery
Chromosome segregation during cell division is carried out by the mitotic spindle, a tiny machine composed of microtubules, motors and associated proteins. Mitosis in human cells is ‘open’, meaning that the nuclear envelope breaks down at prophase.
This is in contrast to ‘closed’ mitosis in lower species. Cell biologists studying mitosis have therefore focused on the mitotic spindle, paying little attention to cellular membranes and organelles in the cell. We have known since the 1950s that the spindle sits in a membrane-free “exclusion zone”, which mimics a closed mitosis system. Outside this zone is a sea of densely packed ER/nuclear envelope and other organelles (collectively called endomembranes).
This begs the question: what happens to chromosomes that find themselves amongst the endomembranes outside the exclusion zone?
Our study show that chromosomes not aligned by the spindle can become ensheathed in multiple layers of endomembranes. This event consigns the chromosome to missegregation and generates a micronucleus that is associated with genomic rearrangements that may drive tumour evolution. We developed a new strategy to clear the ER from live mitotic cells and find that these ensheathed chromosomes could be rescued by the mitotic spindle. We conclude that ensheathing constitutes a novel pathway to aneuploidy.
Congratulations to Professor Kate Seers
Professor Kate Seers has been conferred the honour of being admitted to the Freedom of The Barbers’ Company by Presentation, “in recognition of her immense contribution to the Company’s Clinical Nursing Scholarship Award programme” starting on 19th July 2021. This is a great honour and only 1% of Freemen join via Presentation (where the Court invites them to join the Company).
Congratulations - Professor Sophie Staniszewska
Black women face a significantly higher risk of having a miscarriage than white, according to research involving Prof Siobhan Quenby from WMS.
Our 2021 MB ChB Prizegiving Evening took place on 22 April, celebrating the fantastic work and achievements of our medical students over the last year, as well as recognising members of staff who've gone above and beyond to support them.
Hospice care across the West Midlands has received an exciting boost as WMS researchers have received a quarter of a million pound grant to establish better care for terminally ill patients.
Depletion of a certain type of stem cell in the womb lining during pregnancy could be a significant factor behind miscarriage, according to a study by Warwick Medical School researchers.
We're delighted that our new Interdisciplinary Biomedical Research Building, which we will share with the School of Life Sciences, is now complete, bringing to life Warwick's commitment to delivering world-leading research in neuroscience, microbiology and infection, cell biology, and disease models.
Rachel Spencer (GP Academic Clinical Lecturer with UAPC) has been awarded a highly competitive NIHR Advanced Fellowship. This award is for £850,000 over four years and is the largest funding ever to be handled by Coventry and Rugby CCG.
We are pleased to share news that eight members of the WMS community have secured Fellowships with the University's Institute of Engagement.
Warwick Medical School continues to be proud of the contribution our medical students are making during the ongoing Covid-19 pandemic.
TV and film ‘thump’ is not effective alternative to CPR, researchers at University of Warwick demonstrate
In a new study from Warwick Medical School, the effectiveness of three alternatives to CPR were examined, and it was concluded that none were beneficial.
Co-production of knowledge: the future - BMJ
It is with sadness that we share with you the news that one of our alumni, Rolland Iriarte has recently died. He graduated from the MB ChB programme in 2010 and will be remembered as a gregarious, kind and caring man.
On the UN's International Day of Women and Girls in Science, the University spoke to some our researchers and asked them about their hopes for their research and the importance of equality in their chosen field.
CryoLogyx spin out from GibsonGroup
A new spin out company has been awarded funding from innovateUK to develop new frozen cell products. The company will use technology developed in the Gibsongroup which uses synthetic polymers to protect cells (and other biologics) during freezing, and to make them easier to transport and deliver. The company is being led by a postdoc in the group, Dr Tom Congdon.
Read the press release here
Read about the group’s research here
Congratulations to Professor Felicity Boardman
Congratulations to Professor Felicity Boardman who has been made a Foundation Fellow of the Warwick Institute of Engagement.
Congratulations to Professor Sophie Staniszewska
Congratulations to Professor Sophie Staniszewska who has been made a Foundation Fellow of the Warwick Institute of Engagement. Sophie says becoming a Foundation Fellow creates 'a great link for us and a chance to further embed involvement and engagement in our teaching and research'.
Dr Jean-Pierre Laake, a final year MB ChB student at WMS, who has continued to work as an epidemiologist alongside his studies, is highlighting the need to support good mental health in older adults during the winter months.