A new study led by our Clinical Trials Unit has found that an online rehabilitation programme improves quality of life for adults with long Covid.
New research supported by our Clinical Trials Unit has led to the UK government approving the use of digital pathology to help speed up analysis of cancer screening samples.
Personalized Chronomodulated 5-Fluorouracil Treatment: A Physiologically Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy
This work is based on the discovery of diurnal variations impacting cancer therapy. Especially, use of chronomodulated treatment with 5-fluorouracil (5-FU) has gained significance. Studies indicate high inter-individual variability in diurnal variations in dihydropyrimidine dehydrogenase (DPD) activity – a key enzyme for 5-FU metabolism. However, the influence of individual chronotypes on chronomodulated therapy was unclear but is needed to optimize precision dosing of chronomodulated 5‑FU. Lead by the Thorsten Lehr's PKPD group at the University of Saarland, this collaborative paper is taking a treasure trove of patient 5-FU PK data amalgamated with DPD enzyme activity data from health people to establish a novel PKPD model of 5-FU that captures the extent of diurnal variations in DPD activity and can help investigate individualized chronomodulated 5-FU therapy through testing alternative personalized dosing strategies. Read the paper here.
WMS is leading two revolutionary trials that will compare the treatment benefits of traditional physiotherapy rehabilitation with transplanted knee surgeries.
Warwick Medical School researcher and orthopaedic surgeon awarded prestigious Hunterian Professorship
Dr Imran Ahmed has been recognised with the Hunterian Professorship from the Royal College of Surgeons for his work at WMS on the treatment, experiences, and outcomes of patients with a meniscal tear of the knee.
A national research database led by the Clinical Trials Unit at WMS has revealed stark figures for cardiac arrests in England for 2022, with just 1 in 12 people surviving 30 days after an out-of-hospital cardiac arrest.
A new diagnostic device could help those who experience sleep apnoea get a quicker diagnosis and an improved quality of life, thanks to a trial being led by Warwick Medical School researchers.
Thousands of people with type 1 diabetes could be offered wearable technology to help them manage their condition thanks to guidance based on research conducted by WMS.
The world’s largest review on opioid medicines for cancer pain, which included WMS researchers, has found it is unclear whether some commonly used opioid medicines are better than a placebo and suggests that non-opioid medicines, including aspirin, may be as effective as opioids.
Mammography for some breast cancer survivors could be reduced, according to research led by Warwick Medical School’s Clinical Trials Unit.
A team at Warwick Medical School’s Clinical Trials Unit have won a prestigious award at the Clinical Research Network Awards, alongside colleagues from the West Midlands Ambulance Service.
Associate Professor Meera Unnikrishnan from the Division of Biomedical Sciences has been awarded a Wellcome Discovery Award from the Wellcome Trust to the value of £2,225,509. Her project, ‘Dissecting Clostridioides difficile-host-commensal interactions at the gut interface’, will take place over eight years.
Congratulations to Professor Ponnusamy Saravanan, who has been appointed as the next editor-in-chief of the Royal College of Physicians' oldest journal, Clinical Medicine.
Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function
Work by recent WMS PhD graduate Agnieszka Nagorska and PDRA Andreas Zaucker shows that translational control of an enzyme, FurinA, is important for normal positioning of the heart, and for cardiac valve function. FurinA cleaves the growth factor signal and morphogen, Nodal. Mutant zebrafish embryos with mis-regulated furina show premature and increased levels of FurinA, ectopic Nodal signalling, and defects in heart positioning and valve development. This is similar to human patients with mitral valve regurgitation. The findings pave the way for potential diagnostic tests for patients with heart valve dysfunctions. The work was supported by grants from the Leverhulme Trust, UKRI-BBSRC, MLSRF, and doctoral studentships from Warwick Medical School, MRC DTP, and Warwick-ARAP.
Read the paper hereLink opens in a new window.
Genome wide analysis revealed conserved domains involved in the effector discrimination of bacterial type VI secretion system
Gram negative bacterial pathogens use so called Type VI secretion systems (T6SSs) to deliver virulence effectors into target cells (either animal cells or other bacteria). Besides structural and effector proteins, many other proteins, such as adaptors, co-effectors and accessory proteins, are involved in this process. MIX domains can assist in the delivery of T6SS effectors when encoded as a stand-alone gene or fused at the N-terminal of the effector. However, whether there are other conserved domains exhibiting similar encoding forms to MIX in T6SS remains obscure.
In this work, we scanned publicly available bacterial genomes and established a database which include 130,825 T6SS vgrG loci from 45,041 bacterial genomes. Based on this, we revealed six domain families encoded within vgrG loci, which are either fused at the C-terminus of VgrG/N-terminus of T6SS toxin or encoded by an independent gene. Among them, DUF2345 was further validated and shown to be indispensable for the T6SS effector delivery and LysM was confirmed to assist the interaction between VgrG and the corresponding effector. Together, our results implied that these widely distributed domain families with similar genetic configurations may be required for the T6SS effector recruitment process.
Read the paper here.
Warwick Medical School’s brand-new £4.2m Clinical Education Hub has opened its doors for the first time to students, offering state-of-the-art, purpose-built spaces for Clinical Anatomy and Clinical Skills.
Warwick Medical School have committed to the addition of specialist training on sexual violence awareness and communication skills for their second-year medical students in the 2023/24 academic year.
History Repeats Itself: The Relevance of Historical Pandemics to the Medical School Curriculum
The dramatic global impact of the coronavirus pandemic has increased consideration on epidemiological progressions of pandemics. Measures implemented to reduce viral transmission have been largely historical, comparable in nature with the 1918 and 2009 influenza pandemics, demonstrating the importance of clinicians’ awareness on historical pandemics.
Read the paper here.
Out of the five Warwick academics named in the 2023 Highly Cited Researcher list, we are delighted that three work at Warwick Medical School. Congratulations to Prof Sophie Staniszewska, Prof Jerry Nolan and Prof Dieter Wolke (joint appointment with the Department of Psychology).
New study shows older and frail patients wait longer for emergency hospital care than younger patients
A new study by Warwick Medical School working with the Society for Acute Medicine has found that younger patients with simpler problems are waiting less time for assessments than frail patients with complex care needs.
Assay_ready Cryopreserved Hepatocytes for Toxicity Testing
Liver hepatocytes are the front-line cells for screening new compounds for toxicity. However, hepatocytes are stored frozen in vials, not in monolayers meaning they need substantial processing to be ‘usable’ especially for high throughput screening. To solve this the Gibson and Dallman groups have collaborated, so show that immortalised and primary hepatocytes can be cryopreserved whilst attached to 96 well microplates. These can then be taken from the freezer, and simple thawed and are ready to use in under 24 hours. Post-thaw the cells show equal performance to fresh. This was achieved by careful consideration of the molecular mechanism damage during freezing, with the team using patent-pending controlled ice nucleation technology, rather than a traditional re-formulation of cryoprotectants approach. This work was in collaboration with Cryologyx, a University of Warwick Spin out, which has commercialised aspects of this technology.
Read the paper hereLink opens in a new window.
Passive diffusion accounts for the majority of intracellular nanovesicle transport
Trafficking of proteins, lipids, and other molecules between cellular compartments is carried out by vesicular carriers. Material destined for transfer is packaged into a small trafficking vesicle at the donor compartment; the vesicle must then travel to its destination, before fusing with the target compartment to deliver the material.
Pumpkins make their appearance every Halloween, swiftly disappearing for the next year, but scientists believe we are over-looking their health benefits. Researchers at WMS are keen to share the positive impact pumpkins can have on our health and wellbeing – which range from aiding weight loss, improving skin and even reducing risk of cancer.
The latest release of UK Foundation Programme Office data from 2021 reveals that our MB ChB finalists performed very strongly in their applications to the Foundation Programme, with 98.59% being allocated to one of their top 5 choices. This was the second highest rate in the UK.
Last month, the Met Office reported that July was the UK’s sixth wettest on record, and unsurprisingly the UK had 19% fewer hours of sunshine than average over the month, with 140.3 hours in total.
Researchers at Warwick Medical School say that light is the most important environmental cue for synchronising our biological clock and regulating sleep, which if interrupted can have a detrimental effect on our mood and wellbeing.