Job Title
Associate Professor
Department
WMS - Reproductive Health
Phone
(0)24 7696 8702
Web Link
Research Interests
Tony Shmygol's research is concerned with the mechanisms of electrogenesis, autorhythmicity and Ca signalling in the myometrium. His lab is using patch clamp, sharp microelectrodes, multidimensional digital imaging and confocal microscopy combined with mathematical modelling to investigate the signalling pathways linking the rise in intracellular Ca to the activation of the plasma membrane ion channels. His current projects investigate the role of low voltage activated (T-type) Ca channels in the myometrial autorhythmicity and Ca signalling and the mechanisms of oxytocin-induced potentiation of myometrial contractility. This research ultimately aims at better understanding of the uterine function and providing theoretical basis for improved management of preterm labour.
- Muter, Joanne, Brighton, Paul, Lucas, Emma S., Lacey, Lauren, Shmygol, Anatoly, Quenby, Siobhan, Blanks, Andrew M., Brosens, Jan J., 2016. Progesterone-dependent induction of phospholipase C-related catalytically inactive protein 1 (PRIP-1) in decidualizing human endometrial stromal cells. Endocrinology, 157 (7), pp. 2883-2893
- Sheldon, Rachel E., Shmygol, Anatoly, Berg, Hugo van den, Blanks, Andrew M., 2015. Functional and morphological development of the womb throughout life. Science progress, 98 (Pt 2), pp. 103-127
- Brosens, Jan J., Salker, Madhuri S., Teklenburg, Gijs, Nautiyal, Jaya, Salter, Scarlett, Lucas, Emma S., Steel, Jennifer H., Christian, Mark, Chan, Yi-Wah, Boomsma, Carolien M., Moore, Jonathan D., Hartshorne, Geraldine M., ?ucurovic, Sandra, Mulac-Jericevic, Biserka, Heijnen, Cobi J., Quenby, Siobhan, Groot Koerkamp, Marian J., Holstege, Frank C. P., Shmygol, Anatoly, Macklon, Nick S., 2014. Uterine selection of human embryos at implantation. Scientific Reports, 4
- Xue, Mingzhan, Momiji, Hiroshi, Rabbani, Naila, Barker, Guy C., Bretschneider, Till, Shmygol, Anatoly, Rand, D. A. (David A.), Thornalley, Paul J., 2014. Frequency modulated translocational oscillations of Nrf2 mediate the antioxidant response element cytoprotective transcriptional response. Antioxidants & Redox Signaling
- Shaheen, Fozia, Shmygol, Anatoly, Rabbani, Naila, Thornalley, Paul J., 2014. A fluorogenic assay for methylglyoxal. Biochemical Society Transactions, 42 (2), pp. 548-555
- Sheldon, Rachel E., Baghdadi, Marc, McCloskey, Conor, Blanks, Andrew M., Shmygol, Anatoly, Berg, Hugo van den, 2013. Spatial heterogeneity enhances and modulates excitability in a mathematical model of the myometrium. Journal of The Royal Society Interface, 10 (86), pp. 20130458-20130458
- Kuroda, Keiji, Venkatakrishnan, R., James, S., Sucurovic, S., Mulac-Jericevic, B., Lucas, Emma S., Takeda, Satoru, Shmygol, Anatoly, Brosens, Jan J., Quenby, Siobhan, 2013. Elevated periimplantation uterine natural killer cell density in human endometrium is associated with impaired corticosteroid signaling in decidualizing stromal cells. Journal of Clinical Endocrinology & Metabolism, 98 (11), pp. 4429-4437
- Bru-Mercier, Gilles, Gullam, Joanna E., Thornton, Steven, Blanks, Andrew M., Shmygol, Anatoly, 2012. Characterization of the tissue-level Ca2+signals in spontaneously contracting human myometrium. Journal of Cellular and Molecular Medicine, Vol.16 (No.12), pp. 2990-3000
- Yin, Than, Gullam, J. E., Shmygol, Anatoly, 2011. Comparison of myometrial contractility in normal and obese women. BJOG: An International Journal of Obstetrics & Gynaecology, Vol.118 (No.8), pp. 1017-1017
- Noble, Karen, Floyd, Rachel, Shmygol, Andre, Shmygol, Anatoly, Mobasheri, A., Wray, Susan, 2010. Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium. Cell Calcium, Vol.47 (No.1), pp. 47-54
- Blanks, Andrew M., Zhao, ZhengHang Zhao, Shmygol, Anatoly, Bru-Mercier, Gilles, Astle, Shirley, Thornton, Steven, 2008. Characterization of the molecular and electrophysiological properties of the T-type calcium channel in human myometrium. The Journal of Physiology, Vol.581 (No.3), pp. 915-926
- Gullam, Joanna E., Blanks, Andrew M., Thornton, Steven, Shmygol, Anatoly, 2008. Oxytocin-induced myometrial contractions in the presence of Nifedipine, what is the mechanism?. Reproductive Sciences, Vol.15 (No.2, Suppl.), pp. 116A-116A
- Shmygol, Anatoly, Noble, K., Wray, Susan, 2007. Depletion of membrane cholesterol eliminates the Ca2+-activated component of outward potassium current and decreases membrane capacitance in rat uterine myocytes. Journal of Physiology, Vol.581 (No.2), pp. 445-456
- Borisova, L., Shmygol, Anatoly, Wray, Susan, Burdyga, T., 2007. Evidence that a Ca2+ sparks/STOCs coupling mechanism is responsible for the inhibitory effect of caffeine on electro-mechanical coupling in guinea pig ureteric smooth muscle. Cell Calcium, Vol.42 (No.3), pp. 303-311
- Blanks, Andrew M., Shmygol, Anatoly, Thornton, Steven, 2007. Myometrial function in prematurity. Best Practice & Research: Clinical Obstetrics & Gynaecology, Vol.21 (No.5), pp. 807-819
- Shmygol, Anatoly, Gullam, Joanna, Blanks, Andrew M., Thornton, Steven, 2006. Multiple mechanisms involved in oxytocin-induced modulation of myometrial contractility. Acta Pharmacoligica Sinica, 27 (7), pp. 827-832
- Zhang, Jie, Taggart, Michael J., Thornton, Steven, Shmygol, Anatoly, Blanks, Andrew M., 2010. The pregnancy dependent expression profile of the genomic complement of K plus channels in human myometrial smooth muscle and vasculature. 57th Annual Meeting of the Society-for-Gynecologic-Investigation, Orlando, FL, March 24-27, 2010, Published in Reproductive Sciences, pp. 78A-78A
- Jiménez Roldán, J. E. (José Emilio), Bru-Mercier, Gilles, Blanks, Andrew M., Thornton, Steven, Shmygol, Anatoly, 2009. Extracellular cyclic ADP-ribose modulates Ca signalling in human myometrium. 56th Annual Meeting of the Society for Gynecologic Investigation, Glasgow, Scotland, March 17-21, 2009, Published in Reproductive Sciences, pp. 198A-198A
- Gullam, J. E., Blanks, Andrew M., Thornton, Steven, Shmygol, Anatoly, 2009. Phase-plot analysis of the oxytocin effect on human myometrial contractility. 1st Meeting on Reproductive Bioengineering, Pitztal, Austria, April, 2008, Published in European Journal of Obstetrics, Gynecology and Reproductive Biology, pp. S20-S24
- Bru-Mercier, Gilles, Blanks, Andrew M., Thornton, Steven, Shmygol, Anatoly, 2009. T-type calcium channels contribute to synchronisation of oxytocin(OT)-induced oscillations of intracellular calcium in human myometrium. XXXVI International Congress of Physiological Sciences (IUPS2009) Function of Life: Elements and Integration, Kyoto, Japan, July 27-August 01, 2009, Published in Journal of Physiological Sciences, pp. 363-363
- Bru-Mercier, Gilles, Shmygol, Anatoly, Thornton, Steven, Blanks, Andrew M., 2008. Spontaneous activity and the complex action potential require the myometrial network. 55th Annual Meeting of the Society for Gynecologic Investigation, San Diego, CA, Mar 26-29, 2008, Published in Reproductive Sciences, pp. 114A-115A
- Gullam, J. E., Blanks, Andrew M., Shmygol, Anatoly, Thornton, Steven, 2008. Oxytocin-induced myometrial contractions in the presence of Nifedipine. Royal College of Obstetricians and Gynaecologists 7th International Meeting, Montreal, Canada, 17-20 September 2008, Published in BJOG -An International Journal of Obstetrics & Gynaecology, pp. 123-123
- Shmygol, Anatoly, Blanks, Andrew M., Bru-Mercier, Gilles, Gullam, Joana E., Thornton, Steven, 2007. Control of uterine Ca2+ by membrane voltage toward understanding the excitation-contraction coupling in human myometrium. 5th World Congress of Biomechanics, Munich, Germany, 29 Jul - 4 Aug 2006, Published in Annals of the New York Academy of Sciences, pp. 97-109
- Wray, Susan, Shmygol, Anatoly, 2007. Role of the calcium store in uterine contractility. Seminars in Cell and Developmental Biology, Elsevier Science Ltd. / Academic Press Ltd, pp. 315-320
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Ferring Compound Analysis | Ferring Pharmaceuticals | 01 Feb 2014 | 31 Jan 2015 |
| Cost extension to: Investigation into the mechanism of action of an oxytocin receptor antagonist | GlaxoSmithKline PLC | 28 Feb 2013 | 31 Mar 2014 |
| Ferring Literature Review | Ferring Pharmaceuticals | 01 Jan 2013 | 28 Feb 2013 |
| Investigation into the mechanism of action of an oxytocin receptor antagonist. | GlaxoSmithKline PLC | 01 Jan 2012 | 31 Dec 2012 |
| MRC Capacity Building Studentships. | MRC | 01 Oct 2008 | 30 Sept 2012 |
| Myometrial contractility and labour outcome in obese women | Grace Research Fund | 01 Aug 2010 | 31 Jul 2012 |
| Specific targeting of nifedipine action to the uterus by manipulation of myometrical specific ion channels | Action Medical Research | 01 Jan 2010 | 31 Dec 2011 |
| Control of uterine Ca by membrane potential: role of the T-type Calcium channels | BBSRC | 01 May 2006 | 30 Apr 2009 |