Job Title
Professor
Department
WMS - Biomedical Sciences
Phone
+44 (0)2476 151168
Web Link
Research Interests
Cell division is fundamental to the existence of life. A key part of this process involves the accurate separation of the chromosomes into the two daughter cells - a process called mitosis. Errors in chromosome segregation drive chromosomal instability, aneuploidy and cancer development. Dr. McAinsh's lab of graduate students, postdoctoral fellows and technicians are focused on understanding the mechanisms by which kinetochores power chromosome segregation and how the mitotic spindle is self-assembled and positioned during mitosis in human cells. Approaches in the McAinsh lab include live-cell microscope-based assays, computational image analysis and in vitro reconstitution.
Biography
Andrew McAinsh is a Professor of Cell Biology at Warwick Medical School and holds a Wellcome Trust Senior Investigator Award and Royal Society Wolfson Merit Award. Following a PhD at Cambridge with Steve Jackson and a postdoc at the Massachusetts Institute of Technology with Peter Sorger, where he was Jane Coffin Childs Fellow, he established his independent laboratory in 2005 at the Marie Curie Research Institute. He moved to Warwick in 2009 and is also supported by grants from the BBSRC and MRC.
- 'Harrison, Jonathan, 'Sen, Onur, 'McAinsh, Andrew D., 'Burroughs, Nigel John, 2022. 'Kinetochore tracking in 3D from lattice light sheet imaging data with KiT. Bioinformatics, 38 (12), pp. 3315-3317
- 'Castrogiovanni, Cédric, 'Inchingolo, Alessio, 'Harrison, Jonathan U., 'Dudka, Damian, 'Sen, Onur, 'Burroughs, Nigel John, 'McAinsh, Andrew D., 'Meraldi, Patrick, 2022. 'Evidence for a HURP/EB free mixed-nucleotide zone in kinetochore-microtubules. Nature Communications, 13 (1)
- Sen, Onur, Harrison, Jonathan, Burroughs, Nigel John, McAinsh, Andrew D., 2021. Kinetochore life histories reveal an Aurora-B-dependent error correction mechanism in anaphase. Developmental Cell, 56 (22), pp. 3082-3099
- Germanova, Tsvetelina E., Roscioli, Emanuele, Harrison, Jonathan, McAinsh, Andrew D., Burroughs, Nigel John, 2021. Subcellular Euclidean distance measurements with multicolor fluorescence localization imaging in cultured cells. STAR Protocols, 2 (4)
- Auckland, Philip, Roscioli, Emanuele, Coker, H. L. E., McAinsh, Andrew D., 2020. CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes. Journal of Cell Biology, 219 (5)
- Roscioli, Emanuele, Germanova, Tsvetelina E., Smith, Christopher A., Embacher, Peter A., Erent, Muriel, Thompson, Amelia I., Burroughs, Nigel John, McAinsh, Andrew D., 2020. Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors.. Cell Reports, 31 (4)
- Pesenti, Marion E., Prumbaum, Daniel, Auckland, Philip, Smith, Charlotte M., Faesen, Alex C., Petrovic, Arsen, Erent, Muriel, Maffini, Stefano, Pentakota, Satyakrishna, Weir, John R., Lin, Yu-Chih, Raunser, Stefan, McAinsh, Andrew D., Musacchio, Andrea, 2018. Reconstitution of a 26-Subunit human kinetochore reveals cooperative microtubule binding by CENP-OPQUR and NDC80. Molecular Cell, 71 (6), pp. 923-939
- Hatano, Tomoyuki, Alioto, Salvatore, Roscioli, Emanuele, Palani, Saravanan, Clarke, Scott T., Kamnev, Anton, Hernandez Fernaud, Juan Ramon, Sivashanmugam, Lavanya, Chapa y Lazo, Bernardo, Jones, Alexandra M., Robinson, Robert C., Sampath, Karuna, Mishima, Masanori, McAinsh, Andrew D., Goode, Bruce L., Balasubramanian, Mohan K., 2018. Rapid production of pure recombinant actin isoforms in Pichia pastoris. Journal of Cell Science, 131 (8)
- Currie, Cerys E., Mora-Santos, Maria, Smith, Chris A., McAinsh, Andrew D., Millar, Jonathan B.A., 2018. Bub1 is not essential for the checkpoint response to unattached kinetochores in diploid human cells. Current Biology, 28 (17), pp. R929-R930
- Dudka, Damian, Noatynska, Anna, Smith, Christopher A., Liaudet, Nicolas, McAinsh, Andrew D., Meraldi, Patrick, 2018. Complete microtubule?kinetochore occupancy favours the segregation of merotelic attachments. Nature Communications, 9 (1)
- McHugh, Toni, Drechsler, Hauke, McAinsh, Andrew D., Carter, Nicholas J., Cross, R. A., 2018. Kif15 functions as an active mechanical ratchet. Molecular Biology of the Cell, 29 (4), pp. 1743-1752
- Rhys, Alexander D., Monteiro, Pedro, Smith, Christopher Matthew, Vaghela, Malti, Arnandis, Teresa, Kato, Takuya, Leitinger, Birgit, Sahai, Erik, McAinsh, Andrew D., Charras, Guillaume, Godinho, Susana A., 2017. Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells. The Journal of Cell Biology, 217 (1), pp. 195-209
- Maciejowski, John, Drechsler, Hauke, Grundner-Culemann, Kathrin, Ballister, Edward R., Rodriguez-Rodriguez, Jose-Antonio, Rodriguez-Bravo, Veronica, Jones, Mathew J. K., Foley, Emily, Lampson, Michael A., Daub, Henrik, McAinsh, Andrew D., Jallepalli, Prasad V., 2017. Mps1 regulates kinetochore-microtubule attachment stability via the ska complex to ensure error-free chromosome segregation. Developmental Cell, 41 (2), pp. 143-156.e6
- Sandu, Pamela, Crepin, Valerie F., Drechsler, Hauke, McAinsh, Andrew D., Frankel, Gad, Berger, Cedric N., 2017. The Enterohemorrhagic Escherichia coli effector EspW triggers actin remodeling in a Rac1-dependent manner. Infection and Immunity, 85 (9)
- Auckland, Philip, Clarke, Nicholas I., Royle, Stephen J., McAinsh, Andrew D., 2017. Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment. The Journal of Cell Biology, 216 (6), pp. 1623-1639
- Smith, Chris A., McAinsh, Andrew D., Burroughs, Nigel John, 2016. Human kinetochores are swivel joints that mediate microtubule attachments.. eLife, 5
- Armond, Jonathan W., Vladimirou, Elina, McAinsh, Andrew D., Burroughs, Nigel John, 2016. KiT : a MATLAB package for kinetochore tracking. Bioinformatics, 32 (12), pp. 1917-1919
- Patel, Jessica, Tan, S. L., Hartshorne, Geraldine M., McAinsh, Andrew D., 2016. Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities. Biology Open, 5 (2), pp. 178-184
- Drechsler, Hauke, McAinsh, Andrew D., 2016. Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles. Proceedings of the National Academy of Sciences of the United States of America, 113 (12), pp. E1635-E1644
- Auckland, Philip, McAinsh, Andrew D., 2015. Building an integrated model of chromosome congression. Journal of Cell Science, 128 (18), pp. 3363-3374
- Bancroft, James M., Auckland, Philip, Samora, C. P., McAinsh, Andrew D., 2015. Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways. Journal of Cell Science, 128 (1), pp. 171-184
- Armond, Jonathan W., Vladimirou, Elina, Erent, Muriel, McAinsh, Andrew D., Burroughs, Nigel John, 2015. Probing microtubule polymerisation state at single kinetochores during metaphase chromosome motion. Journal of Cell Science, 128 (10), pp. 1991-2001
- Burroughs, Nigel John, Harry, Edward, McAinsh, Andrew D., 2015. Super-resolution kinetochore tracking reveals the mechanisms of human sister kinetochore directional switching. eLife, 4
- Armond, Jonathan W., Harry, Edward, McAinsh, Andrew D., Burroughs, Nigel John, 2015. Inferring the forces controlling metaphase kinetochore oscillations by reverse engineering system dynamics. PLoS Computational Biology, 11 (11)
- Silió, Virginia, McAinsh, Andrew D., Millar, Jonathan B. A., 2015. KNL1-Bubs and RZZ provide two separable pathways for checkpoint activation at human kinetochores. Developmental Cell, 35 (5), pp. 600-613
- Drechsler, Hauke, McHugh, Toni, Singleton, Martin R., Carter, Nicholas J., McAinsh, Andrew D., 2014. The kinesin-12 Kif15 is a processive track-switching tetramer. eLife, 3
- McAinsh, Andrew D., 2014. How kinetochores CCAN resist force. Developmental Cell, 30 (6), pp. 637-638
- Vázquez-Novelle, María Dolores, Sansregret, Laurent, Dick, Amalie E., Smith, Christopher A., McAinsh, Andrew D., Gerlich, Daniel W., Petronczki, Mark, 2014. Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase. Current Biology, 24 (6), pp. 638-645
- Cross, R. A., McAinsh, Andrew D., 2014. Prime movers : mechanochemistry of mitotic kinesins. Nature Reviews Molecular Cell Biology, 15, pp. 257-271
- Earnshaw, William C., Allshire, R. C., Black, Ben E., Bloom, Kerry S., Brinkley, B. R., Brown, William, Cheeseman, Iain M., Choo, K. H. Andy, Copenhaver, Gregory P., DeLuca, Jennifer G., Desai, Arshad, Diekmann, Stephan, Erhardt, Sylvia, Fitzgerald-Hayes, Molly, Foltz, Daniel R., Fukagawa, T., Gassmann, Reto, Gerlich, D. W., Glover, David M., Gorbsky, G. J. et al (Select to open full list), 2013. Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Research, 21 (2), pp. 101-106
- Vladimirou, Elina, Mchedlishvili, Nunu, Gasic, Ivana, Armond, Jonathan W., Samora, Catarina P., Meraldi, Patrick, McAinsh, Andrew D., 2013. Nonautonomous movement of chromosomes in mitosis. Developmental Cell, 27 (1), pp. 60-71
- Cheeseman, L. P., Harry, Edward, McAinsh, Andrew D., Prior, I. A., Royle, Stephen J., 2013. Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. Journal of Cell Science, 126 (9), pp. 2102-2113
- Kaseda, Kuniyoshi, McAinsh, Andrew D., Cross, R. A., 2012. Dual pathway spindle assembly increases both the speed and the fidelity of mitosis. Biology Open, Vol.1 (No.1), pp. 12-18
- Eskat, Anja, Deng, Wen, Hofmeister, Antje, Rudolphi, Sven, Emmerth, Stephan, Hellwig, Daniela, Ulbricht, Tobias, Döring, Volker, Bancroft, James M., McAinsh, Andrew D., Cardoso, M. Cristina, Meraldi, Patrick, Hoischen, Christian, Leonhardt, Heinrich, Diekmann, Stephan, 2012. Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex. PLoS One, Vol.7 (No.9)
- Drechsler, Hauke, McAinsh, Andrew D., 2012. Exotic mitotic mechanisms. Open Biology, Vol.2
- Cross, R. A., McAinsh, Andrew D., Straube, Anne, 2011. Mechanochemical cell biology. Seminars in Cell & Developmental Biology, Vol.22 (No.9), pp. 913-915
- Vladimirou, Elina, Harry, Edward, Burroughs, Nigel John, McAinsh, Andrew D., 2011. Springs, clutches and motors : driving forward kinetochore mechanism by modelling. Chromosome Research, 19 (3), pp. 409-421
- McAinsh, Andrew D., Meraldi, Patrick, 2011. The CCAN complex : linking centromere specification to control of kinetochore?microtubule dynamics. Seminars in Cell & Developmental Biology, Vol.22 (No.9), pp. 946-952
- Samora, Catarina P., Mogessie, Binyam, Conway, Leslie, Ross, Jennifer L., Straube, Anne, McAinsh, Andrew D., 2011. MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis. Nature Cell Biology, Vol.13 (No.9), pp. 1040-1050
- Jaqaman, K., King, E. M., Amaro, A. C., Winter, J. R., Dorn, J. F., Elliott, Hunter L., Mchedlishvili, N., McClelland, S. E., Porter, I. M., Posch, M., Toso, A., Danuser, G., McAinsh, Andrew D., Meraldi, P., Swedlow, Jason, 2010. Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases. Journal of Cell Biology, Vol.188 (No.5), pp. 665-679
- Amaro, Ana C., Samora, Catarina P., Holtackers, Rene, Wang, Enxiu, Kingston, Isabel J., Alonso, M. (Maria), Lampson, Michael, McAinsh, Andrew D., Meraldi, Patrick, 2010. Molecular control of kinetochore-microtubule dynamics and chromosome oscillations. Nature Cell Biology, Vol.12 (No.4), pp. 319-U42
- Toso, Alberto, Winter, Jennifer R., Garrod, Ainslie J., Amaro, Ana C., Meraldi, Patrick, McAinsh, Andrew D., 2009. Kinetochore-generated pushing forces separate centrosomes during bipolar spindle assembly. Journal of Cell Biology, Vol.184 (No.3), pp. 365-372
- Smith, Chris A., Burroughs, Nigel John, McAinsh, Andrew D., 2018. Mitotic live-cell imaging at different timescales. In Maiato, Helder; Schuh, Melina (eds.), Mitosis and Meiosis Part B, Cambridge, Massachuetts, Elsevier, pp. 1-27
- Samora, Catarina P., McAinsh, Andrew D., 2011. Photoactivatable-GFP-a-tubulin as a tool to study microtubule plus-end turnover in living human cells. In Straube, Anne (ed.), Microtubule Dynamics, Humana Press, pp. 223-233
- McClelland, Sarah E., McAinsh, Andrew D., 2009. Hydrodynamic analysis of human kinetochore complexes during mitosis. In McAinsh, Andrew D. (ed.), Mitosis, Humana Press, pp. 81-98
- 'Currie, Cerys E., 'Ford, Emma, 'Whyte, Lucy Benham, 'Taylor, Deborah M., 'Mihalas, Bettina P., 'Erent, Muriel, 'Marston, Adele L., 'Hartshorne, Geraldine M., 'McAinsh, Andrew D., 2022. 'Data for The first mitotic division of human embryos is highly error prone. University of Warwick, Warwick Medical School
- Currie, Cerys E., Mora-Santos, Maria, Smith, Chris, McAinsh, Andrew D., Millar, Jonathan B. A., 2018. Bub1 is not required for the checkpoint response to unattached kinetochores in diploid human cells. BioRXiv, BioRXiv
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Kinetochore self-correction mechanisms underlying faithful human chromosome segregation | Wellcome Trust | 01 Oct 2023 | 30 Sep 2031 |
| Molecular origin of non-dysjunction in human meiotic and early mitotic divisions | Wellcome Trust | 01 Oct 2019 | 31 Mar 2026 |
| New horizons in fertility research: Why do some eggs not work? | Wellcome Trust | 01 Oct 2020 | 30 Sep 2024 |
| MRC equipment full proposal | MRC | 01 Oct 2022 | 31 Mar 2023 |
| WT Multi-USer Equipment - Full proposal April 2017 | Wellcome Trust | 01 Aug 2017 | 31 Jul 2022 |
| Reconstructing cell surface dynamics from diSPIM microscopy data | BBSRC | 16 Oct 2017 | 15 Oct 2021 |
| Warwick QBP2 ISSF renewal 2016-2021 | Wellcome Trust | 01 Oct 2016 | 30 Sep 2021 |
| Wellcome Trust Senior Investigator Award | Wellcome Trust | 01 Apr 2015 | 31 May 2021 |
| WCPRS - Origins of chromosomal abnormalities in human embryos | University Hospitals Coventry and Warwickshire NHS Trust | 02 Oct 2017 | 01 Apr 2021 |
| Royal Society Wolfson Research Merit Awards | Royal Society | 01 Oct 2015 | 31 Aug 2020 |
| Egg Sharing Research Programme | WPH Charitable Trust | 01 Nov 2018 | 30 Apr 2020 |
| BSCB Hooke Medal | British Society for Cell Biology | 12 Nov 2017 | 11 Nov 2018 |
| Mechanisms of spindle checkpoint silencing (Programme Grant renewal) | MRC | 01 Jan 2013 | 30 Jun 2018 |
| Career Development Fellowship (de Piccoli): Analysis of novel mechanisms of replisome regulation during replication stress (full application) | Cancer Research UK | 01 Oct 2013 | 30 Sep 2016 |
| System-mechanics of the kinetochores: operating principles of a complex mechanochemical engine. | BBSRC | 01 Jan 2012 | 17 Jun 2016 |
| Supplement to Transitional Programme Grant (equipment donated in kind) | Marie Curie Cancer Care | 02 Sep 2010 | 30 Sep 2012 |
| Marie Curie Cancer Care Transitional Programme Grant | Marie Curie Cancer Care | 01 Oct 2009 | 30 Sep 2012 |