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Structural characterization and inhibition of the interaction between ch-TOG and TACC3

In this paper we describe the structure of the interaction between TACC3 and ch-TOG. A single helix from ch-TOG, normally bound to two hairpins, pops out and binds to the coiled-coil of TACC3. We then isolated Affimers (non-antibody binders) that inhibit this interaction in vitro. Moving into cells, we could express the Affimers to inhibit the ch-TOG–TACC3 interaction and found a new function for these two proteins in stabilizing the pericentriolar material.
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Mon 10 Jun 2024, 09:05 | Tags: BMS BMS_newpub

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