Dr Carlos Sánchez Cano
Dr Carlos Sánchez-Cano
"Using X-rays to probe the cellular life of Inorganic systems"
3pm, Wednesday
17 July 2024
C5.21, Chemistry
Dr Carlos Sánchez-Cano joins us from DIPC to deliver this guest seminar. This is a departmental event for all staff and students. Please come along!
"Using X-rays to probe the cellular life of Inorganic systems"
Carlos Sanchez-Cano1,2,3
1 DIPC. Paseo Manuel de Lardizabal, 4, 20018 Donostia / San Sebastian, Gipuzkoa. Spain.
2 Ikerbasque, Basque Foundation for Science, Plaza de Euskadi 5, Bilbao, 48009, Spain.
3 Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia, Kimika Fakultatea, Euskal Herriko Unibertsitatea UPV/EHU, 20018 Donostia-San Sebastian, Spain
carlos.sanchez@dipc.org
The rich chemistry of transition metals permits them to undergo a great variety of reactions when found in biological environments. As such, metals fulfil multiple fundamental tasks in life organisms, and the homeostasis of bio-metals (i.e. Fe, Zn and Cu) is highly regulated. Equally, numerous anthropogenic metallic devices such as inorganic complexes or metal nanomaterials are currently being developed as biomedical or biotechnological tools. However, the same varied reactivity shown by metals makes challenging to explore their fate and mechanisms of action in biological samples, hampering their development into clinical or industrial use.
Synchrotron-based X-ray imaging and spectroscopic techniques can provide valuable insight on the distribution and chemical properties of complexes and nanomaterials in biological environments, as they allow direct detection of metals -4 and can reach subcellular spatial resolution (Figure).5-6 This can prompt dramatic improvements in the design and development of new and more effective metal-based drugs and medical nanodevices.
[1]Sanchez-Cano C. et al, ACS Nano, 2021, 15, 3754-3807.
2Aires A., Maestro D., del Rio J., Palanca A., López-Martínez E., Llarena I., Geraki K., Sanchez-Cano C., Villar A.V., Cortajarena A., Chem. Sci., 2021, 12,2480.
3Liu Y., Kornig C., Qi B., Schmultzer O., Staufer T., Sanchez-Cano C., Magel E., White J. C., Feliu N., Gruner F., Parak W.J., ACS Nano, 2022, 16, 12941.
4Martínez-Parra L., Piñol-Cancer M., Sanchez-Cano C., Miguel-Coello A. B., Di Silvio D., Gomez A. M., Uriel C., Plaza-García S., Gallego M., Pazos R., Groult H., Jeannin M., Geraki K., Fernández-Méndez L., Urkola-Arsuaga A., Sánchez-Guisado M. J., Carrillo-Romero J., Parak W. J., Prato M., Herranz F., Ruiz-Cabello J., Carregal-Romero S., ACS Nano, 2023, 17, 13811.
5Bolitho E.M., Coverdale J. P. C., Bridgewater H. E., Clarkson G. J., Quinn P. D., Sanchez-Cano C., Sadler P. J., Angew. Chem. Intl. Ed., 2021, 60, 6462-6472.
6Skiba M., Guedes G., Karpov D., Feliu N., Cortajarena A. L., Parak W. J., Sanchez-Cano C., Int. J. Mol. Sci., 2024, 25, 528.