Professor Liz Campbell Lecture
Prof Liz Campbell
Corinne P. Greenberg
Women & Science Professor,
The Rockefeller University
"Dual targeting of transcription: Synergistic approaches to enhance TB treatments and eliminate resistance"
Warwick Structural Biology Lecture
PLT, Science Concourse, Main Campus
13:00 Thursday 21 May, 2026
Abstract
Mycobacterium tuberculosis (Mtb), the deadliest human pathogen, develops resistance to rifampicin (Rif), a key first-line TB therapy. Rifampicin resistance (RifR) compromises treatment efficacy, causing prolonged therapy, treatment failure, and resistance spread. To address these challenges, the Campbell lab explores transcription as a multi-stage target—an approach that reduces RifR evolution, eliminates prevalent RifR strains, and potentiates Rif activity in granulomas, highlighting a viable strategy for tackling drug-resistant and latent TB