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Department of Chemistry

ARBRE CD study sign-up


WG 4 (Optimization of Data Quality) is setting up a benchmarking study on circular diochroism (CD) spectroscopy under the lead of Dr. Nikola Chmel. A pilot CD study(Powerpoint Presentation) has been conducted previously (in 2014 and 2015, involving eight labs) in order to give an overview of the present state of CD data quality across selected laboratories and a range of instruments across the network. It became apparent, even in such a small scale study, that there were significant differences in quality of the data recorded in different labs. Various issues were identified (intensity calibration, wavelength calibration, baseline drift) indicating that there is a need for a broader study within the ARBRE-MOBIEU community in order to give better picture of CD data quality and to take steps in order to improve the data quality and standardisation across the network. The follow-up study, starting on the 30th May 2017, is intended to allow us a much more in-depth analysis of the issues around standardisation and calibration of the CD instrumentation as well as to introduce good practice trough distribution of standard operating procedures (SOP) allowing for better comparability between the different labs and instruments.

 

Time frame of the CD benchmarking study:

22nd May 2017 – deadline for CD benchmarking study sign up

30th May – 2nd June 2017 – samples and measurement SOPs distributed to the participating labs

June - July 2017 – data collection in the participating labs

14th August 2017 – deadline for the return of samples and data to Warwick

August – September 2017 - re-measurement of returned samples at Warwick, data analysis (STSM)

 

Format of the study:

Each of the participating labs will be send 4 samples (1 sample of protein, 2 enantiomers of CD standard and a blank). Each lab will be asked to perform CD measurements on all samples:

  • using the lab own SOP
  • using the supplied SOP
  • provide recent (less than 7 days) calibration data for wavelength (e.g. Ho, ammonia, etc) and intensity (e.g. ACS), if no recent calibration data is available, the lab will be asked to check the calibration instrument using the lab own SOP or the supplied SOP
  • samples will be need to be re-measured after calibration if required.

 

If you are interested please sign up using the form below before 22nd May 2017:




 

 

 
Would you be willing to help with running the study?

 
Are you happy for the anonymised results of the study to be published in a peer reviewed publication/publically accessible report?
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