Mass Spectrometry
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Instruments |
Experiments available |
Mass range |
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PerkinElmer 5300DV ICP-OES, |
For all metal/semimetal trace analysis,0.01-100ppm for OES,1-1000ppt for ICP-MS |
0-250 m/z |
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Bruker Ultraflex Extreme and Autoflex Speed MALDI TOF/TOF |
For high Mw protein and polymers, more tolerate towards salt and detergent(50mM or similar) |
50-200,000 m/z (extended to 500,000) |
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Agilent 5977B GC-MS (EI/CI) |
Only for small volatile very hydrophobic compounds, need to be thermally stable |
20-1,000 m/z |
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Agilent 6130B single Quad (ESI) |
Routine Mw for relative polar compounds, need to be salt free |
50 - 3,000 m/z |
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Bruker Compact, Bruker MaXis II, MaXis Plus and MaXis Impact Q-TOF (ESI-HR-MS/MS) |
Can achieve <5ppm on MicroTOF or sub-ppm mass accuracy on MaXis, no salt and detergent |
50-20,000 m/z probably up to 150KDa molecules |
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Bruker Amazon X+Bruker HCT-plus+Bruker HCT Ultra ETD+Bruker Amazon ETD+Thermo LTQ-XL+Waters Xevo TQXS and TQD(ESI) |
LC/ESI/MS/MS (unit resolution and 50-100ppm mass accuracy) |
50-3,000 m/z (6000 extended range) |