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Dr Manuela Tosin

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Dr Manuela Tosin

Laurea in Chemistry (cum laude), University of Padova (Italy); PhD, University College Dublin (Ireland); MRSC.

Associate Professor of Organic Chemistry 

Research Summary

Development of chemical probes/tools aiming at (i) uncovering the details of complex mechanisms involved in natural product biosynthesis; (ii) generating novel natural products of improved pharmacological activity; (iii) exploring new sources of natural products.

Selected Publications

A Light-Activated Acyl Carrier Protein 'Trap' for Intermediate Capture in Type II Iterative Polyketide Biocatalysis. S. L. Kilgour; D. P. A. Kilgour; P. Prasongpholchai; P. B. O' Connor*; M. Tosin*. Chem. Eur. J. 2019, VIP article, accepted (DOI:10.1002/chem.201903662).

Novel Chemical Probes for the Investigation of Nonribosomal Peptide Assembly. Y. T. C. Ho.; D. J. Leng; I. Wilkening; D. P. Bushell; O. Kostner; E. Riva; J. Havemann; D. Passarella; M. Tosin* Chem. Commun. 2017, 53, 7088-7091.

Chemical Probing of Thiotetronate Bio-Assembly. J. Havemann; M. E. Yurkovich; R. Jenkins; S. Harringer, W. Tao; S. Wen; Y. Sun; P. F. Leadlay; M. Tosin* Chem. Commun. 2017, 53, 1912-1915.

Second-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assembly. I. Wilkening; S. Gazzola; E. Riva; J. S. Parascandolo; L. Song; M. Tosin.* Chem. Commun. 2016, 52, 10392-10395.

Novel insights into 6-methylsalicylic acid bio-assembly via chemical probes. J. S. Parascandolo; J. Havemann; H. K. Potter; F. Huang; E. Riva; J. Connolly; I. Wilkening; L. Song; P. F. Leadlay; M. Tosin.* Angew. Chem. Int. Ed. 2016, 55, 3463-3467.

A Genomics-led Approach to Deciphering the Mechanism of Thiotetronate Antibiotic Biosynthesis. W. Tao; M. E. Yurkovich; S. Wen; K. B. Lebe; M. Samborskyy; Y. Liu; A. Yang; Y. Liu; Y. Ju; Z. Deng; M. Tosin; Y. Sun; P. F. Leadlay. Chem. Sci. 2016, 7, 376-385.

Chemical Probes for the Functionalization of Polyketide Intermediates. E. Riva, I. Wilkening, S. Gazzola, W. M. A. Li, L. Smith, P. F. Leadlay, M. Tosin.*Angew. Chem. Int. Ed. 2014, 53, 11944-11949 (VIP article).