Dr Paul Wilson

Leverhulme Trust Early Career Fellow & Monash-Warwick Senior Research Fellow

MSci (Bristol), PhD (Warwick)

email: p.wilson.1@warwick.ac.uk

tel: +44(0)24 765 23961

Office C200A

Research Interests

Research Interests:

Reversible deactivation radical polymerisation; organic synthesis; protein/peptide-polymer conjugation; antimicrobial/therapeutic peptides; redox active protein/peptides; electrochemical synthesis; electrochemical surface modification.

Ongoing projects include;

• Polymeric arsenicals as a functional platform for nanomaterials and nanomedicine
• Engineering novel therapies for potent but restrictively toxic antimicrobial peptides
• Engineering biological (nano)materials using natural and directed amyloidogenesis
• Nanoscale control over 3D surface topology using localised electrochemical synthesis

Publication record (see below):

To date (co)author of 71 publications including 68 peer reviewed articles (5 in J. Am. Chem. Soc), 1 peer reviewed review (Chem. Rev.), 1 book chapter, 1 invited talent article, 1 invited contribution to an upcoming emerging investigators issue of Polym. Chem. Metrics: > 2100 citations, h-index = 27 (Google Scholar).

Invited lectures and presentations:

2017

1.Thiol reactive polymer scaffolds as a platform for site specific bioconjugation and functional biomaterials; 4th Sino-UK Bilateral Symposium on Macromolecules and Soft Matter in Hefei, China

2. Thiol reactive polymer scaffolds as a platform for site specific bioconjugation and functional biomaterials; Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, China

3.Thiol reactive polymer scaffolds as a platform for site specific bioconjugation and functional biomaterials; Fudan University, China.

2016

1. Polymeric arsenicals and glycopolymers as specific macromolecular therapeutics; Australasian Polymer Symposium, Australia

2. Efficient and selective protein/peptide-polymer conjugation targeting disulfides; Next Generation Macromolecular Therapeutics Workshop, Melbourne, Australia

3. Synthesis, evaluation and application of arsenical-linked polymer bioconjugates; Warwick Polymer Conference, UK

2014

1. Macromolecular arsenicals; from toxic interest to therapeutic potential; Victoria Polymer Technologies Workshop, Melbourne, Australia

Contributed lectures and presentations:

2017

1. Engineering novel therapies for the delivery of antimicrobial peptides – systemic and topical delivery of colistin; British Council, Newton-Bhabha Fubd Researcher Links Workshop on Proteins, Peptides and Metals in Disease and Therapy, Indian Institute of Technology Kanpur, India.

2. Thiol-reactive (co)polymer scaffolds comprised of organic arsenical acrylamides; 12th International Conference on Advanced Polymers for Macromolecular Engineering, Ghent, Belgium, 2017.

2016

1. Polymeric arsenicals; a novel functional platform for (nano)materials and nanomedicine; Recent Appointees in Polymer Science, Loughborough, UK

2014

1. Arsenicals as highly selective linkers for protein/peptide-polymer conjugation; ACS Controlled Radical Polymerisation Symposium, San Francisco, USA

2. Macromolecular arsenicals; from toxic interest to therapeutic potential; International Nanomedicine Conference, Sydney, Australia

2012

1. Polymer Logistics; Smart Polymers for Cargo Transport and Triggered Release; Warwick Polymer Conference, UK,

Funding and projects

2016 – 2019 PI – Leverhulme Trust Early Career Fellowship, University of Warwick (ECF/2015-075; £102,915) ‘Synthesis, evaluation and application of arsenical-linked polymer bioconjugates’

2016 – 2017 PI - 2016/17 EPSRC Institutional Award (Global Challenges Research Fund)
(£46,559, 80% fEC) 'Addressing maternal mortality in the developing world’

Selected publications (Google Scholar)

* Denotes corresponding authorship

*Organic arsenicals as functional motifs in polymer and biomaterials science J. Tanaka, T. P. Davis, P. Wilson Macromol. Rapid Commun. 2018, Accepted

Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide E. H. Pilkington, O. J. R. Gustafsson, Y. Xing, J. Hernandez-Fernaud, C. Zampronio, A. Kakinen, A. Faridi, F. Ding, P. Wilson, P. Ke, T. P. Davis ACS Nano, 2018, DOI: 10.1021/acsnano.8b02346

High resolution visualization of the redox activity of Li2O2 in non-aqueous media: conformal layer vs. toroid structure P. E. Sharel, M. Kang, P. Wilson, L. Meng, D. Perry, A. Basile, P. R. Unwin Chem. Commun. 2018, 54, 3053-3056

*Synthesis, aggregation and responsivity of block copolymers containing organic arsenicals J. Tanaka, S. Tani, R. Peltier, E. H. Pilkington, A. Kerr, T. P. Davis, P. Wilson Polym. Chem. 2018, 9, 1551-1556 (Emerging Investigators Special Issue)

*Thiol-reactive (co) polymer scaffolds comprised of organic arsenical acrylamides C. Footman, P. A.J.M. de Jongh, J. Tanaka, R. Peltier, K. Kempe, T. P. Davis, P. Wilson Chem. Commun. 2017, 53, 8447-8450

Reversible surface functionalisation of emulsion-templated porous polymers using dithiophenol maleimide functional macromolecules A. M. Eissa, P. Wilson, C. Chen, J. Collins, M. Walker, D. M. Haddleton, N. R. Cameron Chem. Commun. 2017, 53, 9789-9792

Hydrolyzable Poly(PEGA) Colistin Prodrugs through Copper-mediated Photo-induced Living Radical Polymerization C. Zhu, E K. Schneider, V. Nikolaou,T Klein, J. Li, T. P. Davis, M. R. Whittaker,P. Wilson, K. Kempe, T. Velkov, D. M. Haddleton Bioconjugate Chem. 2017 DOI: 10.1021/acs.bioconjchem.7b00242

*Specific and differential binding of N-acetylgalactosamine glycopolymers to the human Macrophage Galactose Lectin and Asialoglycoprotein Receptor J. Tanaka, A. S. Gleinich, Q. Zhang, R. Whitfield, K. Kempe, D. M. Haddleton, T. P. Davis, S. Perrier, D. A. Mitchell, P. Wilson Biomacromolecules 2017 18, 1624-1633

*Synthesis and Applications of Protein/Peptide‐Polymer Conjugates P. Wilson, Macromol. Chem. Phys. 2017, DOI:10.1002/macp.201600595

A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria C. Zhu, E. K. Schneider, J. Wang, K. Kempe, P. Wilson, T. Velkov, J. Li, T. P. Davis, M. R. Whittaker, D. M. Haddleton J. Control. Release 2017, DOI: 10.1016/j.jconrel.2017.02.005

Comb poly(oligo(2-ethyl-2-oxazoline)methacrylate)-peptide conjugates prepared by aqueous Cu(0)-mediated polymerization and reductive amination J. Collins, S. J. Wallis, A. Simula, M. R. Whittaker, M. P. McIntosh, P. Wilson, T. P. Davis, D. M. Haddleton, K. Kempe Macromol. Rapid. Commun. DOI: 10.1002/marc.201600534

Poly (2-oxazoline)-based micro-and nanoparticles: A review P. Wilson, P. C. Ke, T. P. Davis, K. Kempe Eur. Polym. J. 2016, DOI:10.1016/j.eurpolymj.2016.09.011

A hydrogel based localized release of Colistin for antimicrobial treatment of burn wound infection C. Zhu, J. Zhao, K. Kempe, P. Wilson, J. Wang, T. Velkov, J. Li, T. P. Davis, M. R. Whittaker D. M. Haddleton Macromol. Biosci. 2016, DOI: 10.1002/mabi.201600320

Synthesis of well-defined catechol polymers for surface functionalization of magnetic nanoparticles Q. Zhang, G. Nurumbetov, A. Simula, C. Zhu, M. Li, P. Wilson, K. Kempe, B. Yang, L. Tao D. M. Haddleton Polym. Chem. 2016, 7, 7002-7010

Facile one-pot/one-step synthesis of heterotelechelic N-acylated poly(aminoester) macromonomers for carboxylic acid decorated comb polymers P. A. J. M. de Jongh, M. R. Bennett, G. S. Sulley, P. Wilson, T. P. Davis, D. M. Haddleton, K. Kempe Polym. Chem. 2016, 7, 6703-6707

Dual stimuli-responsive comb polymers from modular N-acylated poly(aminoester)-based macromonomers P. A. J. M. de Jongh, A. Mortiboy, G. S Sulley, M. R. Bennett, A. Anastasaki, P. Wilson, D. M. Haddleton, K. Kempe ACS Macro Lett., 2016, 5, 321–325

*Surface patterning of polyacrylamide gel using scanning electrochemical cell microscopy (SECCM) E. E. Oseland, Z. J. Ayres, A. Basile, D. M. Haddleton, P. Wilson, P. R. Unwin Chem. Commun. 2016, 52, 9929 - 9932

Stability enhancing N-terminal PEGylation of oxytocin exploiting different polymer architectures and conjugation approaches J. Collins, K. Kempe, P. Wilson, C. A. Blindauer, M. P. McIntosh, T. P. Davis, M. R. Whittaker, D. M. Haddleton Biomacromolecules 2016, 17, 2755-2766

Reversible regulation of thermoresponsive property of dithiomaleimide-containing copolymers via sequential thiol exchange reactions Z. Tang, P. Wilson, K. Kempe, H. Chen, D. M. Haddleton ACS Macro Letters, 2016, 5, 709-713

Cu(0)-mediated living radical polymerization: A versatile tool for materials synthesis A. Anastasaki, V. Nikolaou, G. Nurumbetov, P. Wilson, K. Kempe, J. F. Quinn, T. P. Davis, M. R. Whittaker, D. M. Haddleton, Chem. Rev. 2016, 116, 835-877.

Well-defined protein/peptide-polymer conjugates by aqueous Cu-LRP: Synthesis and Controlled Self-Assembly Q. Zhang, M. Li, C. Zhu, G. Nurumbetov, Z. Li, P. Wilson, K. Kempe, D. M. Haddleton, J. Am. Chem. Soc. 2015, 137, 9344–9353.

*Organic arsenicals as efficient and highly specific linkers for protein/peptide–polymer conjugation P. Wilson, Anastasaki, M. R. Owen, K. Kempe, D. M. Haddleton, S. K. Mann, A. P. R. Johnston, J. F. Quinn, M. R. Whittaker, P. J. Hogg, T. P. Davis, J. Am. Chem. Soc. 2015, 137, 4215–4222.

In situ conjugation of dithiophenol maleimide polymers and oxytocin for stable and reversible polymer–peptide conjugates J. Collins, J. Tanaka, P. Wilson, K. Kempe, T. P. Davis, M. P. McIntosh, M. R. Whittaker, D. M. Haddleton, Bioconjugate Chem. 2015, 26, 633–638.

*Synthesis and reactivity of α,ω-homotelechelic polymers by Cu(0)-mediated living radical polymerization A. Simula, G. Nurumbetov, A. Anastasaki, P. Wilson, D. M. Haddleton, Eur. Polym. J., 2015, 62, 294-303

Multiblock sequence-controlled glycopolymers via Cu (0)-LRP following efficient thiol–halogen, thiol–epoxy and CuAAC reactions Q. Zhang, A. Anastasaki, G-Z. Li, A. J. Haddleton, P. Wilson, D. M. Haddleton, Polym. Chem. 2014, 5, 3876-3883

Synthesis and aggregation of double hydrophilic diblock glycopolymers via aqueous SET-LRP Q. Zhang, P. Wilson, A. Anastasaki, R. McHale, D. M. Haddleton, ACS Macro Lett., 2014, 3, 491-495.

Magnetic nanoparticles with diblock glycopolymer shells give lectin concentration-dependent MRI signals and selective cell uptake J, Basuki, L. Esser, H. Duong, Q. Zhang, P. Wilson, M. R. Whittaker, D. M. Haddleton, C. Boyer, T. P. Davis Chem. Sci., 2014, 5, 715-726.

Copper(II)/tertiary amine synergy in photoinduced living radical polymerization: Accelerated synthesis of ω-functional and α,ω-heterofunctional poly(acrylates) A. Anastasaki, V. Nikolaou, Q. Zhang, J. A. Burns, S. Samanta, C. Waldron, A. J. Haddleton, R. McHale, D. J. Fox, V. Percec, P. Wilson, D. M. Haddleton, J. Am. Chem. Soc., 2014, 136, 1141–1149.

Aqueous copper-mediated living polymerization: Exploiting rapid disproportionation of CuBr with Me6TREN Q. Zhang, P. Wilson, Z. Li, R. McHale, J. Godfrey, A. Anastasaki, C. Waldron and D. M. Haddleton, J. Am. Chem. Soc., 2013, 135, 7355-7363.

Conjugation-induced fluorescent labeling of proteins and polymers using dithiomaleimides M. P. Robin, P. Wilson, A. B. Mabire, J. K. Kiviaho, J. E. Raymond, D. M. Haddleton, R. K. O'Reilly, J. Am. Chem. Soc., 2013, 135, 2875-2878.