Preparing for the Next Generation: Understanding Epigenetic Remodelling in the Human Germline
Dr Wolfram Gruhn, Assistant Professor, Biomedical Sciences Directorate, WMS

Abstract: In most multicellular species, the germline forms the foundation of the life cycle, serving as an enduring link between generations. In humans, the process of forming sperm and eggs is initiated in the early embryo and spans more than a decade. During this time, developing germ cells undergo profound epigenetic changes and mitochondrial selection, processes that promote cellular "rejuvenation" and establish the foundation for normal development in the next generation. Disruptions in these processes can result in infertility, cancer, or abnormal offspring development.

Here, I will discuss our efforts to decipher epigenetic remodelling in human primordial germ cells and our strategies to recapitulate this process using embryonic stem cell-derived systems.

Assembly of eukaryotic flagella – lessons from the small and mighty trypanosome
Dr Samuel Dean, Associate Professor, Biomedical Sciences Directorate, WMS

Abstract: Our research investigates the molecular mechanisms of eukaryotic flagella assembly using African trypanosomes as a model organism. These pathogenic protozoa rely on their flagella for virulence and transmission. We specifically focus on characterising assembly and nucleation factors located in a key subdomain at the flagellar base, aiming to better understand the construction and regulation of these essential organelles.