Recent Developments in the Patho-Physiological Molecular Clocks Lab
We are recruiting! now closed
We are looking for a postdoctoral fellow to work on an inter-disciplinary project characterising mechanism of action and chronotherapeutic potential of novel organometallic complexes together with Prof Peter Sadler's lab. Please get in touch for details and see here for the application page.
Good Luck Rachael!
MBio student Rachael has achieved a first in her degree and has been accepted a stipend to start on the MRC DTP in IBR in September. Well done Rachael and have fun in the next four years at Warwick!
New URSS and MSc students in the lab!
Two new students have joined the lab for projects over the summer.
Daniel Fox, 2nd year medical student at Warwick, has received competitive URSS funding as well as BSN project funding to conduct a project on the circadian regulation of the blood brain barrier in a mammalian in vitro model.
Vadim Vasilyev, MSc in Interdisciplinary Biomedical Research, will work on establishing a TimeTeller model for in vitro tumour models.
Welcome to both!
Chronotherapy: Counting down cancer
Medical News Today spoke with Robert for their “what’s exciting the experts” series. Asked what recent advances have given them the most hope and is most exciting, the obvious answer is Chronotherapy.
Frequency of the PROMs
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In a collaboration led by Pasquale Innominato, we evaluate the impact of different frequencies for the evaluation of patient-reported outcomes (PRO) in cancer. PRO have proven relevant positive clinical impact on patients’ communication with healthcare professionals, decision-making for management, wellbeing and overall survival. However, the optimal frequency of PRO assessment has yet to be defined. Based on the assumption that more frequent sampling would enhance accuracy, we aimed at identifying the optimal sampling frequency that does not miss clinically relevant insight. Our analysis suggests that in patients receiving chemotherapy for advanced cancer, increasing the density of PRO collection enhances the accuracy of PRO assessment to a clinically meaningful extent. This is valid for both computation of averages symptom burden and for the recognition of episodes of severe symptom intensity. |
