I joined the Division of Microbiology and Infection within Warwick Medical School in May 2013 as a Senior Research Fellow in Microbial Bioinformatics. My previous research has focused on phage host interactions in the marine environment. Having been involved in the isolation, genome sequencing and annotation of a number of phage capable of infecting cyanobacteria. Much of my research had focused on using the model system of S-PM2 and Synechococcus sp WH7803 to understand how cyanophage interact with their host. I identified the first 'photosynthetic genes' in a cyanophage genome, and more recently identified an antisense RNA that may have role in the regulation of these genes. My future research will shift focus to bacterial pathogens, broadly to understand the role phage have in pathogenicity. I currently collaborating with Dr Martha Clokie (University of Leicester) on bioinformatic analysis of several novel Clostridium difficile isolates and their prophages.
I completed my PhD at the University of Warwick in 2003 under the supervision of Prof Nick Mann on the molecular characterisation of marine cyanophages.I continued my interest in bacteriophages, working for Professors Nick Mann and Dave Scanlan on projects utilising microarrays to study the gene expression of both cyanophages and their hosts. The use of comparative genomic hybridisations combined with bioinformatic analysis to determine the core genes within cyanophages. I continue to be involved in the sequencing and annotation of a number of bacteriophages. More recently I have investigated how genomic islands within Synechococcus strains give rise to very different responses to nutrient limitation.
- Puxty, Richard J., Millard, Andrew D., 2023. Functional ecology of bacteriophages in the environment. Current Opinion in Microbiology, 71
- Rihtman, Branko, Puxty, Richard John, Hapeshi, Alexia, Lee, Yan-Jiun, Zhan, Yuanchao, Michniewski, Slawomir, Waterfield, Nicholas R., Chen, Feng, Weigele, Peter, Millard, Andrew D., Scanlan, David J., Chen, Yin, 2021. A new family of globally distributed lytic roseophages with unusual deoxythymidine to deoxyuridine substitution. Current Biology, 31 (14), pp. 3199-3206.e4
- Townsend, Eleanor, Kelly, Lucy, Gannon, Lucy, Muscatt, George, Dunstan, Rhys, Michniewski, Slawomir, Sapkota, Hari, Kiljunen, Saija J., Kolsi, Anna, Skurnik, Mikael, Lithgow, Trevor, Millard, Andrew D., Jameson, Eleanor, 2021. Isolation and chacterisation of Klebsiella phages for phage therapy. PHAGE Therapy, Applications, and Research, 2 (1), pp. 26-42
- Rangel-Pineros, Guillermo, Millard, Andrew D., Michniewski, Slawomir, Scanlan, David J., Sirén, Kimmo, Reyes, Alejandro, Petersen, Bent, Clokie, Martha R. J., Sicheritz-Pontén, Thomas, 2021. From trees to clouds : PhageClouds for fast comparison of ?640,000 phage genomic sequences and host-centric visualization using genomic network graphs. PHAGE : Therapy, Applications, and Research, 2 (4), pp. 194-203
- Grigonyte, Aurelija, Harrison, Christian, Macdonald, Paul R., Montero-Blay, Ariadna, Tridgett, Matthew, Duncan, John, Sagona, Antonia P., Constantinidou, Chrystala, Jaramillo, Alfonso, Millard, Andrew D., 2020. Comparison of CRISPR and marker-based methods for the engineering of Phage T7. Viruses, 12 (2)
- Leungtongkam, Udomluk, Thummeepak, Rapee, Kitti, Thawatchai, Tasanapak, Kannipa, Wongwigkarn, Jintana, Styles, Kathryn, Wellington, Elizabeth M. H., Millard, Andrew D., Sagona, Antonia P., Sitthisak, Sutthirat, 2020. Genomic analysis reveals high virulence and antibiotic resistance amongst phage susceptible Acinetobacter baumannii. Scientific Reports, 10
- Styles, Kathryn, Thummeepak, Rapee, Leungtongkam, Udomluk, Smith, Sophie, Christie, Gabrielle S., Millard, Andrew D., Moat, John, Dowson, Christopher G., Wellington, Elizabeth M. H., Sitthisak, Sutthirat, Sagona, Antonia P., 2020. Investigating bacteriophages targeting the opportunistic pathogen Acinetobacter baumannii. Antibiotics, 9 (4)
- Back, J.J., Blake, Thomas, Brossa Gonzalo, A., Costa Sobral, C. M., Crocombe, Andrew, Gershon, T. J., Kreps, Michal, Latham, Thomas, Loh, David, Mathad, Abhijit, Millard, Andrew D., Poluektov, Anton, Wicht, Jean, 2019. Dalitz plot analysis of the D+ -> K-K+K+ decay. Journal of High Energy Physics
- Slater, Ross T., Frost, Lucy R., Jossi, Sian E, Millard, Andrew D., Unnikrishnan, Meera, 2019. Clostridioides difficile LuxS mediates inter-bacterial interactions within biofilms.. Scientific Reports, 9 (1)
- Jones, Helen J., Kröber, Eileen, Stephenson, Jason, Mausz, Michaela A., Jameson, Eleanor, Millard, Andrew D., Purdy, Kevin J., Chen, Yin, 2019. A new family of uncultivated bacteria involved in methanogenesis from the ubiquitous osmolyte glycine betaine in coastal saltmarsh sediments. Microbiome, 7
- Simpson, Daniel H., Hapeshi, Alexia, Rogers, Nicola J., Brabec, Viktor, Clarkson, Guy J., Fox, David J., Hrabina, Ondrej, Kay, Gemma L., King, Andrew, Malina, Jaroslav, Millard, Andrew D., Moat, John, Roper, David I., Song, Hualong, Waterfield, Nicholas R., Scott, Peter, 2019. Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways. Chemical Science, 10, pp. 9708-9720
- Back, J. J., Blake, Thomas, Brossa Gonzalo, A., Costa Sobral, C. M., Crocombe, Andrew, Gershon, T. J., Kreps, Michal, Latham, Thomas, Loh, David, Mathad, Abhijit, Millard, Andrew D., Vesterinen, M., 2019. Measurement of B+, B0and ?0bproduction in pPbcollisions at vsNN=8.16??TeV. Physical Review D (Particles, Fields, Gravitation and Cosmology)
- Jameson, Eleanor, Stephenson, Jason, Jones, Helen J., Millard, Andrew D., Kaster, K., Purdy, Kevin J., Airs, R., Murrell, J. C. (J. Colin), Chen, Yin, 2019. Deltaproteobacteria (Pelobacter) and Methanococcoides are responsible for choline-dependent methanogenesis in a coastal saltmarsh sediment. ISME Journal, 13 (2), pp. 277-289
- Perez-Sepulveda, Blanca, Pitt, Frances Diana, N?Guyen, A. N., Ratin, M., Garczarek, L., Millard, Andrew D., Scanlan, David J., 2018. Relative stability of ploidy in a marine Synechococcus across various growth conditions. Environmental Microbiology, 10 (4), pp. 428-432
- Puxty, Richard John, Evans, David J., Millard, Andrew D., Scanlan, David J., 2018. Energy limitation of cyanophage development : implications for marine carbon cycling. ISME Journal, 12, pp. 1273-1286
- Michniewski, Slawomir, Redgwell, Tamsin, Scanlan, David J., Millard, Andrew D., 2017. Draft genome sequence of Bacteriophage vB_Eco_swan01. Genome Announcements, 5 (28), pp. 1-17
- Guy, Collette S., Tichauer, Esther, Kay, Gemma L., Phillips, Daniel J., Bailey, Trisha L., Harrison, James, Furze, Christopher M., Millard, Andrew D., Gibson, Matthew I., Pallen, Mark J., Fullam, Elizabeth, 2017. Identification of the anti-mycobacterial functional properties of piperidinol derivatives. British Journal of Pharmacology, 174 (14), pp. 2183-2193
- Sazinas, Pavelas, Smith, Carrie, Suhaimi, Aqilah, Hobman, Jon L., Dodd, Christine, Millard, Andrew D., 2016. Draft genome sequence of the Bacteriophage vB_Eco_slurp01. Genome Announcements, 4 (6)
- Higgins, P. G., Chan, J. Z.-M., Seifert, H., Pallen, Mark J., Millard, Andrew D., 2016. Draft genome sequences of 11 clinical isolates of Acinetobacter baumannii. Genome Announcements, 4 (2)
- Perez-Sepulveda, Blanca, Redgwell, Tamsin, Rihtman, Branko, Pitt, Frances Diana, Scanlan, David J., Millard, Andrew D., Hantke, Klaus, 2016. Marine phage genomics : the tip of the iceberg. FEMS Microbiology Letters, 363 (15)
- Rihtman, Branko, Meaden, Sean, Clokie, Martha R. J., Koskella, Britt, Millard, Andrew D., 2016. Assessing Illumina technology for the high-throughput sequencing of bacteriophage genomes. PeerJ, 4, pp. 1-21
- Pitt, Frances Diana, Millard, Andrew D., Ostrowski, Martin, Dervish, Suat, Mazard, Sophie, Paulsen, Ian T., Zubkov, Mikhail V., Scanlan, David J., 2016. A sample-to-sequence protocol for genus targeted transcriptomic profiling : application to marine Synechococcus. Frontiers in Microbiology, 7
- Puxty, Richard J., Millard, Andrew D., Evans, David J., Scanlan, David J., 2016. Viruses inhibit CO2 fixation in the most abundant phototrophs on earth. Current Biology, 26 (12), pp. 1585-1589
- Hargreaves, Katherine R., Otieno, James R., Thanki, Anisha, Blades, Matthew J., Millard, Andrew D., Browne, Hilary P., Lawley, Trevor D., Clokie, Martha R. J., 2015. As clear as mud? Determining the diversity and prevalence of prophages in the draft genomes of estuarine isolates of Clostridium difficile. Genome Biology and Evolution, 7 (7), pp. 1842-1855
- Puxty, Richard John, Perez-Sepulveda, Blanca, Rihtman, Branko, Evans, David J., Millard, Andrew D., Scanlan, David J., 2015. Spontaneous deletion of an ?ORFanage? region facilitates host adaptation in a ?photosynthetic? cyanophage. PLoS One, 10 (7), pp. 1-13
- Millard, Andrew D., Hands-Portman, Ian, Zwirglmaier, Katrin, 2014. Morphotypes of virus-like particles in two hydrothermal vent fields on the East Scotia Ridge, Antarctia. Bacteriophage, 4 (1)
- Chan, Jacqueline, Millard, Andrew D., Mann, Nicholas H., Schäfer, Hendrik, 2014. Comparative genomics defines the core genome of the growing N4-like phage genus and identifies N4-like Roseophage specific genes. Frontiers in Microbiology, 5
- Puxty, Richard John, Millard, Andrew D., Evans, David J., Scanlan, David J., 2014. Shedding new light on viral photosynthesis. Photosynthesis Research, 126 (1), pp. 71-97
- Barnett, James P., Millard, Andrew D., Ksibe, Amira Z., Scanlan, David J., Schmid, Ralf, Blindauer, Claudia A., 2012. Mining genomes of marine cyanobacteria for elements of zinc homeostasis. Frontiers in Microbiology, 3
- Chan, Yi-Wah, Mohr, Remus, Millard, Andrew D., Holmes, Antony B., Larkum, Anthony W. D., Whitworth, Anna L., Mann, Nicholas H., Scanlan, David J., Hess, Wolfgang R., Clokie, Martha R. J., 2011. Discovery of cyanophage genomes which contain mitochondrial DNA polymerase. Molecular Biology and Evolution, Vol.28 (No.8), pp. 2269-2274
- Clokie, Martha R. J., Millard, Andrew D., Mann, Nicholas H., 2010. T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology. Virology Journal, 7
- Millard, Andrew D., Gierga, G., Clokie, Martha R. J., Evans, David J., Hess, Wolfgang R., Scanlan, David J., 2010. An antisense RNA in a lytic cyanophage links psbA to a gene encoding a homing endonuclease. ISME Journal, The, Vol.2010 (No.4), pp. 1121-1135
- Jia, Ying, Shan, Jinyu, Millard, Andrew D., Clokie, Martha R. J., Mann, Nicholas H., 2010. Light-dependent adsorption of photosynthetic cyanophages to Synechococcus sp. WH7803. FEMS Microbiology Letters, 310 (2), pp. 120-126
- Sánchez-Romero, María Antonia, Busby, S. (Stephen), Ott, Sascha, Dyer, Nigel, Millard, Andrew D., Grainger, David C., 2010. Dynamic distribution of SeqA protein across the chromosome of Escherichia coli K-12. mBio, Vol.1 (No.1), pp. Article number e00012-10
- Millard, Andrew D., Zwirglmaier, Katrin, Downey, Mike J., Mann, Nicholas H., Scanlan, David J., 2009. Comparative genomics of marine cyanomyoviruses reveals the widespread occurrence of Synechococcus host genes localized to a hyperplastic region : implications for mechanisms of cyanophage evolution. Environmental Microbiology, 11 (9), pp. 2370-2387
- Millard, Andrew D., Mann, Nicholas H., 2006. A temporal and spatial investigation of cyanophage abundance in the Gulf of Aqaba Red Sea. Journal of the Marine Biological Association of the United Kingdom, Vol.86 (No.3), pp. 507-515
- Clokie, Martha R. J., Millard, Andrew D., Mehta, Jaytry Y., Mann, Nicholas H., 2006. Virus isolation studies suggest short-term variations in abundance in natural cyanophage populations of the Indian Ocean. Journal of the Marine Biological Association of the United Kingdom, Vol.86 (No.3), pp. 499-505
- Mann, Nicholas H., Clokie, Martha R. J., Millard, Andrew D., Cook, A. (Annabel), Wilson, W. H. (William H.), Wheatley, P. J., Letarov, Andrey, Krish, H. M, 2005. The genome of S-PM2, a "photosynthetic" T4-type bacteriophage that infects marine Synechococcus strains. Journal of Bacteriology, 187 (9), pp. 3188-3200
- Somerfield, Paul J., Muhling, Martin, Fuller, Nicholas J., Millard, Andrew D., Dominique, Marie, Wilson, W. H., Scanlan, David J., Post, Anton F., Joint, Ian, Mann, Nicholas H., 2005. Genetic diversity of marine Synechococcus and co-occurring cyanophage communities : evidence for viral control of phytoplankton. Environmental Microbiology, 7 (4), pp. 499-508
- Clokie, Martha R. J., Millard, Andrew D., Wilson, William H., Mann, Nicholas H., 2003. Encapsidation of host DNA by bacteriophages infecting marine Synechococcus strains. 8th Symposium on Aquatic Microbial Ecology (SAME-8), Sicily, Italy, 25-29 Oct 2002, Published in FEMS Microbiology Ecology, pp. 349-352
- Bailey, Shaun, Clokie, Martha R. J., Millard, Andrew D., Mann, Nicholas H., 2004. Cyanophage infection and photoinhibition in marine cyanobacteria. Research in Microbiology, Elsevier Science BV, pp. 720-725
- Mann, Nicholas H., Cook, A. (Annabel), Millard, Andrew D., Bailey, S. (Shaun), Clokie, Martha R. J., 2003. Marine ecosystems : bacterial photosynthesis genes in a virus. Nature, Nature Publishing Group
Title | Funder | Award start | Award end |
---|---|---|---|
The farm environment: an overlooked reservoir of Mycobacterium bovis? | BBSRC | 01 Apr 2016 | 31 Mar 2020 |
BBSRC / Achten / EnteroBase: A Powerful, User-Friendly Online Resource for Analyzing and Visualizing Genomic Variation within Escherichia coli and Salmonella enterica | BBSRC | 01 Apr 2014 | 15 Oct 2019 |
Protistan grazing and viral infection of marine picoplankton: a role for the host cell surface? | NERC | 31 Dec 2012 | 31 Dec 2016 |